The engineering of space systems is a collaborative, iterative process that integrates various domain-specific viewpoints to represent the final system. To ensure consistency across these viewpoints, the European Space Agency (ESA) employs Model-Based System Engineering (MBSE) and Semantic-Based System Engineering (SBSE) methodologies together to improve digital continuity and interoperability across collaborative space system developments. One significant application of semantic engineering in SE is the ESA MBSE Methodology. The ESA MBSE Methodology provides a standardized approach aligned with the European Cooperation for Space Standardization (ECSS), promotes interoperability across MBSE methodologies and tools, and overcomes integration challenges. ESA MBSE Methodology is the input for the Overall Semantic Modeling for Space System Engineering (OSMoSE) which leverages interoperability in the space community. Case studies, such as the EagleEye Earth Observation mission, demonstrate practical applications, highlighting how semantic models enhance efficiency in complex space systems. This paper discusses the importance of semantics and data management in SE and presents a practical solution derived from the ESA MBSE Methodology.