Keeping in view the design of short to medium-span bridges in critical locations such as road/river crossings under the action of oppositely moving high-speed loads, this paper presents a hybrid model for the prediction of dynamic displacement employing a theoretical non-dimensional framework aided by an artificial neural network (ANN). The introduction of such a hybrid model reduces parametric space and time. The feed-forward ANN is implemented to train the comprehensive data set obtained from the non-dimensional theoretical scheme. The dimensionless input to ANN comprises the bridge and load parameters, whereas maximum dynamic displacement is the output parameter. The robustness and efficiency of the proposed surrogate ANN framework in terms of computational efficiency are compared with the conventional mode-superposition method formulated in dimensionless form. The training of test and validated data sets results in best-fit models with optimistic statistical metrics and accuracy [Formula: see text] 6%. Moreover, the sensitivity of different parameters to the displacement response is highlighted using Pearson’s correlation and Quantile–Quantile plots. To incorporate the best-fit models into the design by bypassing the high-fidelity model, a user-friendly interface is developed, confirming the standards of the high-speed rating code (TZY2014-232 2014). Such interfaces have the potential for wide application in the preliminary design of short-to medium-span bridges under opposite moving loads in critical locations such as crossing valleys, rivers, and railroads.