In this paper, a cascaded extended state observer- based sliding mode control (SMC) is proposed for the typical microgrid (MG) interfaced dc-dc boost converter. For a given MG system, the power fluctuation is unpredictable, which may cause an unstable dc-bus voltage. In that situation, all the dc-bus connected electronic loads cannot work normally. In order to maintain a stable dc-bus voltage, additional power sources with a suitable power converter and the advanced controller are necessary. Especially, the controller for the power converter plays a crucial role in reducing the power fluctuation and regulating the dc-bus voltage. In this paper, to improve the ability of the converters to reject external power disturbance, a cascaded extended state observer is designed to estimate the lumped disturbance more accurately. Besides, the continuous SMC method is adopted to provide a feedback control loop. The corresponding simulation results could highly validate the effectiveness of the proposed control method.