Modality Expression Research Articles

LA MODA L I DAD EPISTÉM ICA ASERTIVA COMO RECURSO RETÓRICO EN NOTICIAS CIENTÍFICAS: EL CASO DEL HALLA ZGO PALEON TOLÓGICO DEL HOMBRE DE ORCE

In this article I analyze assertive epistemic modality (expression of certainty) in a series of scientific news reports on the paleontological discovery of the so-called Hombre of Orce, published in El País between 1983 and 1977. The discovery of a small skull fragment was initially attributed to the oldest hominoid found in Eurasia, yet later analyses indicated that it might really be from an equidae. I describe linguistic forms of the lexical type, the semantic contents (credibility, verification, conviction and confirmation) as well as the social and epistemological rhetorical functions of modalizers such as tajantemente, verificación, cre e r, ratificar, poder afirm a r. The study reveals that in the analyzed corpus these markers of certainty are mainly used to transmit confidence and reliability to the reader in the case of the strongly refuted thesis.

The mesenchyme in cancer therapy as a target tumor component, effector cell modality and cytokine expression vehicle

Tissues and organs harbor a component of supportive mesenchymal stroma. The organ stroma is vital for normal functioning since it expresses factors instructing growth and differentiation along with molecules that restrain these processes. Similarly, the growth of tumors is strictly dependent on the tumor stroma. This review first discusses the possibility of developing tools to block the propagation of the tumor-associated stroma, that may halt tumor progression. It further describes how the tropism of mesenchymal stroma to tumor sites may be utilized to cause regression of the cancerous tissue. Mesenchyme can be genetically modified to overexpress specific regulatory molecules with known effects on specific tumors, such as interferon beta, studied in the context of melanoma and glioma and activin A, a transforming growth factor beta cytokine, examined in multiple myeloma. These studies point to the possibility that genetically modified mesenchymal cells may be used as a therapeutic modality for incurable human diseases. It is proposed that further development of methods of tumor stroma targeting, or alternatively the use of stromal mesenchyme as a cell or cell/gene therapy modalities, may yield novel clinical tools for the treatment of human cancers.

Survival in small cell lung carcinoma is independent of Bcl-2 expression

Bcl-2 overexpression is a common event in small cell carcinomas (SCLC). The bcl-2 oncoprotein has a unique oncogenic role by inhibiting programmed cell death (apoptosis), resulting in tumorigenesis and chemoresistance. Forty-two cases of SCLC were stained immunohistochemically with bcl-2 monoclonal antibody (Biogenex, San Ramon, CA) after using an antigen retrieval step with citrate buffer. bcl-2 positivity was determined as detection of the oncoprotein in greater than 10% of noncrushed neoplastic cells. Twenty-five of 42 (60%) patients had extensive disease at presentation, 10 of 42 (24%) had limited disease, and 7 of 42 (16%) had disease localized to the lung. Twenty-four of 42 (57%) tumors were bcl-2 positive, and 18 of 42 (43%) tumors were bcl-2 negative. Follow-up in patients ranged from 7 days to 96 months (mean follow-up, 20 months). The median survival of patients with bcl-2-positive tumors was 11 months, as opposed to 13 months for bcl-2-negative tumors. There was no significant difference in median survival between bcl-2-positive and bcl-2-negative SCLC (log rank test, P = .2256). Using Cox's proportional hazards model, median survival in SCLC was determined to be independent of age at diagnosis, stage at presentation, therapeutic modality, and bcl-2 expression. bcl-2 expression does not significantly influence survival in SCLC.