ABSTRACT Prevention is the key to reducing human trafficking prevalence, and awareness-raising campaigns are the most common form of trafficking intervention; however, there is little evidence that these activities translate to actions that prevent human trafficking. The “otherness” issue – the belief that human trafficking is a problem for “other” communities but not a problem within one’s own community – has been identified as a potential barrier to effective human trafficking prevention interventions. In this article, we unpack the “otherness” issue and build on Todres (2009) “otherness-aware” framework to develop a theoretical model for understanding otherness within the context of human trafficking prevention interventions. Drawing on evidence from public health, we discuss the community mobilization intervention framework, which is centered on partnership and community engagement, as a potentially useful strategy for addressing the “otherness” issue and improving the effectiveness of human trafficking prevention interventions. We conclude that meaningful partnership with communities is a key to developing contextually relevant, community-empowering approaches to prevent human trafficking. This article has implications for achieving UN Sustainable Development Goal (SDG) 16, which aims to support inclusive communities through targets such as reducing violence, ending human trafficking and amplifying developing countries’ participation in global decision-making.