The rapid evolution of mobile computing technology has been attributed to the increasing capitalizing by companies on this innovative business medium. The result of conformity between technology advancement and market demand increment for mobility has led to the development of different categories of mobile businesses in recent years. This research reviews the previous related literature to the subject and by deploying meta-synthesis as a systematic quantitative method; a generic model covering important factors contributing to mobile application diffusion is presented. The proposed comprehensive model consists of users' specifications, technical aspects and contextual factors in the first level. This article also represents the logical relationship expected to be valid between these factors as conceptual framework, which could be investigated in future studies. the proposed influencing factors as a generic model can help developers and mobile business analysts to have a comprehensive understanding about the contexts may influence their mobile application success or failure.