End-stage renal disease (ESRD) is a condition in which kidney function is permanently impaired. Exercise training programs in people with ESRD have been reported to be beneficial. Outcome measures used to assess effectiveness of such programs must be reliable in order to have confidence in the results. To be accepted as reliable, measures must be capable of differentiating among the clients on whom the measurements are being applied (relative reliability), and must provide consistent values on repeated testing with only small errors of measurement (absolute reliability). Absolute reliability has not yet been determined for common mobility measures used in people with ESRD. PURPOSE To determine the relative and absolute test-retest reliability of the 6-minute walk (6MWT) and timed sit-to-stand in 30 seconds tests (TSS30) in people with ESRD. METHODS 18 people (71 ± 12 yr, 12 males) with ESRD carried out 6MW and TSS30 tests just prior to dialysis on two occasions one week apart. Outcome measures were distance walked (metres) in 6 minutes and number of completed sit-to-stands in 30 seconds. Relative reliability was assessed using the intraclass correlation coefficient (ICC2,1) and absolute reliability was assessed with the standard error of measurement (SEM) and minimal detectable change (MDC95) statistics. RESULTS All tests were completed without incident. Relative test-retest reliability was excellent for both the 6MWT (ICC2.1=0.88) and TSS30 (ICC2,1=0.90). Absolute test-retest reliability was poor by comparison. The SEM and MDC95 for the 6MWT were 32 m and 89 m respectively, and for the TSS30, 1.7 and 2.5 repetitions respectively. CONCLUSION Sample variability improves relative reliability and reduces absolute reliability. In this sample of people with ESRD, the 6MWT and TSS30 provide reliable relative estimates of performance and are thus appropriate for distinguishing among groups of subjects. However, the magnitude of the absolute reliability statistics suggests that more practice trials are required in order to improve consistency of individual performance in these two mobility measures. Supported by a Baxter Research Award through the London Health Sciences Centre.