AbstractThe article examines the relationship between quarantine practices and Western European medical notions of the Ottoman Empire in the eighteenth-century Mediterranean, as well as the crucial role of quarantine centres in facilitating trade and mobility between the East and the West. I argue that quarantine should be analysed to understand the complexity of the early modern Mediterranean as a shared context that saw both connections and clashes. The first part of the article focuses on Western European ideas concerning the geography of the Mediterranean, medical theories, and related quarantine practices. These theories often presented the ‘healthy’ ‘Christian West’ as opposed to the ‘infidel’ and ‘plagued’ Ottoman Empire. However, the article argues for a more nuanced understanding of the early modern Mediterranean, where both unity and diversity co-existed. Quarantine, despite its association with isolation and the reinforcement of borders, also enabled connections and circulation despite the fear of plague. This article explores quarantine centres as key components of the infrastructure of mobility, with a particular focus on religious diversity, tolerance, and multilingualism. The article also explores the perception of the institution through the eyes of Ottoman passengers, shedding light on their perspectives and attitudes toward quarantine.