MnFe2O4 Nanoparticles Research Articles

Plasmonic/magnetic liposomes based on nanoparticles with multicore-shell architecture for chemo/thermotherapy

Multifunctional nanosystems are capable to carry one or more therapeutic agents (thermal and/or targeting agents and chemotherapeutic drugs), offering the capability to concurrently perform different treatment modalities using a single nanosystem. Cluster nanostructures, consisting of densely packed aggregates of magnetic nanoparticles, have shown enhanced heating capabilities. Their combination with plasmonic nanoparticles enable synergistic behavior between dual hyperthermia (magneto-photothermia), allowing overheating cancer cells while increasing drug toxicity. In this work, multicore magnetic nanoparticles (NPs) of MnFe2O4 were prepared using oxamide and melamine as clustering agents. The multicore NPs prepared with oxamide were covered with a gold shell, resulting in multicore magnetic/plasmonic NPs with an increased SAR of 173.80 W/g, under NIR light. Liposomes based on these magnetic/plasmonic NPs were prepared and the model drug curcumin was loaded in these nanocarriers with a high encapsulation efficiency. The fusion between the curcumin-loaded magnetic/plasmonic liposomes and models of cell membranes (labelled with Nile Red) was confirmed by FRET, pointing the magneto/plasmonic liposomes as promising for dual cancer therapy (combined hyperthermia and chemotherapy).

Arsenic removal from solution using nano-magnetic compound: optimization modeling by response surface method.

This study was aimed to investigate the effectiveness of compounds containing iron and manganese to reduce the mobility of arsenic and its effective adsorption and optimize the arsenic adsorption process by CCD. In this study, MnFe2O4 nanoparticles (MFO-n) were synthesized using the co-precipitation method to remove arsenic and reduce its toxicity in solution. Several tests including Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), X-ray fluorescence (XRF), and Brunauer-Emmett-Teller (BET) tests were used to characterize the synthesized MFO-n. To model and optimize the As adsorption process using the response surface methodology, four independent variables affecting the efficiency of arsenic adsorption were investigated. These variables including pH (3 to 11), concentration of arsenic in solution (1000 to 4000µg/L), concentration of nanoparticles (1 to 5g/L), and time (15 to 195min) were investigated. The central composite design (CCD) approach was used to design the experiments and optimize the model parameters. The variance analysis indicated that the prediction of As adsorption from solution by the synthesized nanoadsorbent using the CCD model was well performed (p < 0.0001) with high accuracy (R2 = 0.97). The results further indicated that the optimum quantity of pH, concentration of nanoparticles, time, and initial concentration of As are 5, 2g/L, 60min, and 3250µg/L, respectively. The highest As elimination from the solution was estimated to be 94.77%. Our results further indicated that MFO-n had high efficiency in eliminating both toxic arsenic species from the solution.

Enhanced tumor penetration for efficient chemotherapy by a magnetothermally sensitive micelle combined with magnetic targeting and magnetic hyperthermia.

The high accumulation and poor penetration of nanocarriers in tumor is a contradiction of nanomedicine, which reduces the efficacy of chemotherapy. Due to the positive effect of hyperthermia on in vivo drug diffusion, we designed a magnetothermally sensitive micelle (MTM) by integrating magnetic targeting (MT), magnetic hyperthermia (MH), and magnetothermally responsive drug release to facilitate simultaneous drug accumulation and penetration in tumor. Accordingly, we synthesized a cyanine7-modified thermosensitive polymer with phase transition at 42.3°C, and utilized it to prepare drug-loaded MTMs by encapsulating superparamagnetic MnFe2O4 nanoparticles and doxorubicin (DOX). The obtained DOX-MTM had not only high contents of DOX (9.1%) and MnFe2O4 (38.7%), but also some advantages such as superparamagnetism, high saturation magnetization, excellent magnetocaloric effect, and magnetothermal-dependent drug release. Therefore, DOX-MTM improved in vitro DOX cytotoxicity by enhancing DOX endocytosis under the assistance of MH. Furthermore, MT and MH enhanced in vivo DOX-MTM accumulation and DOX penetration in tumor, respectively, substantially inhibiting tumor growth (84%) with excellent biosafety. These results indicate the development of an optimized drug delivery system with MH and MH-dependent drug release, introducing a feasible strategy to enhance the application of nanomedicines in tumor chemotherapy.

One-Step Pyrolysis Fabrication of Magnetic Bagasse Biochar Composites with Excellent Lead Adsorption Performance.

In the present study, a magnetically separable adsorbent, manganese ferrite (MnFe2O4)/sugarcane bagasse biochar magnetic composites (MFSCBB-MCs), was fabricated through a one-step pyrolysis method. The characterization of the prepared adsorbents indicated that MnFe2O4 nanoparticles were successfully embedded into the biochar matrix, offering magnetic separability and increasing the negative charges on the surface relative to the pristine biochar. Batch adsorption tests indicated that the adsorption of lead on MFSCBB-MCs was pH- and dose-dependent. The experimental results were effectively fitted using the pseudo-second-order kinetic model (R 2 > 0.99) and the Langmuir isotherm equation (R 2 > 0.99), indicating the main chemisorption pathway and monolayer coverage process. Meanwhile, lead adsorption was found to be spontaneous and endothermic, as shown by the study of thermodynamic parameters. The maximum capacity, q m, calculated from the Langmuir model was 155.21 mg·g-1 at 25 °C, demonstrating excellent adsorption capability compared with several previously reported bagasse adsorbents. Based on adsorption mechanism analysis, physical adsorption, electrostatic attraction, and complexation were all involved in the lead(II) adsorption process on MFSCBB-MCs. Furthermore, the adsorbent was easily regenerated as indicated by the high magnetic separation and chemical desorption potential after five cycles, so it is a cost-effective and environmentally favorable adsorbent for wastewater lead removal.

X-ray photoelectron spectroscopy and temperature-dependent electrical transport properties of MnFe2O4-reduced graphene oxide nanocomposites

The reduced graphene oxide (rGO) sheets are assembled with MnFe2O4 (MFO) nanoparticles via an in-situ sol–gel autocombustion route to obtain MFO@rGO nanocomposites. The investigation of their structural and electrical properties is carried out through X-ray photoelectron spectroscopy (XPS) and impedance analyzer, respectively. XPS study discloses the presence of C, O, Fe, and Mn in the MFO@rGO composite, indicating the decoration of MnFe2O4 nanoparticles by rGO sheets. XPS study also reflects the mixed Fe3+/Fe2+ oxidation states of Fe and mixed Mn2+/Mn3+oxidation states of Mn in the composite. The highest value of ac conductivity (σac = 7.51 × 10−6 Ω−1 cm−1 at 1 MHz) at room temperature is obtained within the vicinity of the percolation threshold when rGO content is 20 wt%. The ac conductivity of composites increases with frequency up to 100 °C and then becomes independent of the frequency with a further increase in temperature. The impedance gradually decreases with temperature, revealing the occurrence of negative temperature coefficient of resistance effect in composites. The findings suggest that the MFO@rGO composites can be a potential nominee for the fabrication of electrodes for supercapacitors and flexible electronic devices of low resistance and high electrical conductivity for high-frequency applications.

Fabrication of Z-scheme MnFe2O4@SiO2/TiO2 composite used for 304 stainless steel photocathodic protection

TiO2 nanotubes have large specific surface area. Loading MnFe2O4 on the surface of TiO2 nanotube array can improve the photocatalytic activity of TiO2 and effectively inhibit the corrosion of 304SS. MnFe2O4@SiO2/TiO2 (MSTs) composites were prepared by hydrothermal method. In this study, the effect of doping SiO2 coated MnFe2O4 nanoparticles on the photoelectrochemistry of TiO2 was investigated. The results demonstrated that the doped composite films widen the absorption range of visible light and effectively improve the separation rate of photogenerated electrons and holes. In addition, MSTs can provide protection for 304SS under intermittent illumination for 12 h.

Phosphate Ion Removal from Synthetic and Real Wastewater Using MnFe2O4 Nanoparticles: A Reusable Adsorbent.

The purpose of this study was to eliminate phosphate (P) from wastewater using MnFe2O4 nanoparticles. BET, TGA/DTG, FTIR, SEM, TEM, VSM, XRD and EDX/Map analyses were used to determine the MnFe2O4 surface properties. The specific surface area of the adsorbent was 196.56 m2/g and VSM analysis showed that the adsorbent has a ferromagnetic property. The maximum P sorption efficiency using MnFe2O4 (98.52%) was achieved at pH 6, temperature of 55 °C, P concentration of 10 mg/L, time of 60 min, and sorbent dosage of 2.5 g/L, which is a significant value. Also, the thermodynamic study indicated that the P sorption process is spontaneous and endothermic. Moreover, the utmost sorption capacity of P using MnFe2O4 was 39.48 mg/g. Besides, MnFe2O4 can be used for up to 6 reuse cycles with high sorption efficiency (>91%). Also, MnFe2O4 was able to remove phosphate, COD, and BOD5 from municipal wastewater with considerable removal efficiencies of 82.7%, 75.8%, and 77.3%, respectively.

Efficient removal of antimony by a facile liquid-controlled strategy reinforced hematite-spinel (Fe2O3-MnFe2O4) composite: construction, simulation and practical evaluation

Currently, aqueous antimony contamination has become a non-negligible issue due to its scale industrious production and potential health risk. Herein, we prepare a novel hematite-spinel (Fe2O3-MnFe2O4) adsorbent by a one-step hydrothermal method for aqueous antimony deep purification, in which interfacial Fe-Mn bidentate complex sites are determined as the reinforced one by X-ray absorption spectroscopy (XAS) analysis and density functional theory (DFT) simulation. Through facile alkaline control by NH3·H2O and Fe/Mn proportion adjustment, the intrinsic synthesis kinetics of materials are precisely regulated that MnFe2O4 nano-particles successfully in-situ form on the Fe2O3 surface, in which sufficient adsorption sites are guaranteed by the small size effect. The adsorption experiment further demonstrates that the composite material is effective in Sb(III) and Sb(V) elimination, in which the adsorption capacity reaches up to 42.7 (Sb(III)) and 32.4 mg·g−1 (Sb(V)) (initial concentration 5.0 mg·L−1). The Sb K edge Extended X-ray absorption fine structure (EXAFS) analysis shows that antimony molecules occur as two typical complexation forms on the MnFe2O4 interface, in which an edge-sharing with Fe-O octahedron (Fe-Fe-ES) and two corner-sharing with Fe-O octahedron and Mn-O tetrahedron (Fe-Mn-CS) are exhibited. Further DFT calculations indicate that the Fe-Mn-CS has the highest adsorption energy for Sb(III) (-3.31 eV) and Sb(V) (-5.12 eV), which is rationally interpreted by the compatible overlapping of Fe 3d and O 2p as well as interfacial electron redistribution in Mn atom. This work may represent a new strategy in structure design and provide an alternative perspective in adsorption mechanism illustration.

Synthesis of MnFe2O4 Nanoparticles as a Basic Material for Microwave Absorber

This work aimed to synthesize MnFe2O4 nanoparticles using the coprecipitation method. Manganese chloride dihydrate (MnCl2.4H2O) and iron sand from South Cianjur, Indonesia, were used as a precursor for MnFe2O4 nanoparticle synthesis. The iron sand elements and compounds were tested using X-Ray Fluorescence (XRF). MnFe2O4 nanoparticle was characterized using X-Ray Diffraction (XRD), Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX), and Vector Network Analyzer (VNA). The X-Ray Fluorescence test result showed that 70.54% of South Cianjur contained iron sand. The SEM test result showed that the nanoparticles have an average size of 73.75 nm with a round shape, which was attributed to the agglomeration process. The EDX test result showed that the synthesized nanoparticle contained only Mn, Fe, and O elements without contaminants. The XRD test result showed that the crystal phase of MnFe2O4 was formed with a crystal size of less than 27 nm. The largest reflection losses in the 11.5 - 12.5 GHz range were found in MnFe2O4 with 1:2 variation, i.e., 35.08 dB. This study found that adding iron sand increases MnFe2O4 microwave absorption.

Photocatalytic aspect of rGO/MnFe2O4 as an efficient magnetically retrievable catalyst for reduction of nitroaromatic compounds under visible-light irradiation

In this work a binary photocatalyst of rGO and MnFe2O4 was prepared completely using one-pot hydrothermal simple method. In this way, in a reaction vessel, graphene oxide was reduced and at the same time, MnFe2O4 nanoparticles were formed on its surface. The obtained catalyst was characterized by N2 adsorption, FT-IR, XPS, HRTEM, XRD, FESEM and VSM physicochemical techniques. The rGO/MnFe2O4-50 % exhibits high photocatalytic efficiency for reduction of nitroaromatic compounds given to corresponding amines at ambient temperature. In this study, the kinetic parameter (k) of the reduction reaction was investigated. The catalyst was especially excellent in conversion of 1, 4-dinitrobenzene (99 % in 30 min), 4-bromonitrobenzene (100 % in 60 min) and 4-chloronitrobenzene (100 % in 70 min). In addition to the photocatalytic behavior of rGO/MnFe2O4-50 %, the recyclability of MnFe2O4 was exploited and the catalyst was used for a number of times in the nitrobenzene photocatalytic test without observing a significant decreasing in efficiency.

Co-Precipitation Synthesis of MnFe2O4 and CoFe2O4 Nanoparticles

Nano-sized magnetic manganese ferrite, cobalt ferrite particles were produced by a co-precipitation method at room temperature. The effects of pH value of solutions, where the particles were synthesized, on the morphology and crystal structure of the MnFe 2 O 4 and CoFe 2 O 4 particles were investigated. The particles were pure and nearly spherical shaped. The sizes of synthesized magnetic nanoparticles had between 55 nm and 84 nm, with uniform morphologies. As the pH value increased, the diameter of the synthesized particles decreased and agglomeration of the nanoparticles increased. Keywords: cobalt ferrite, co-precipitation, manganese ferrite, nanoparticle DOI: 10.7176/CMR/14-3-03 Publication date: August 31 st 2022

Investigation of Structural, Morphological and Magnetic Properties of MFe2O4 (M = Co, Ni, Zn, Cu, Mn) Obtained by Thermal Decomposition.

The structural, morphological and magnetic properties of MFe2O4 (M = Co, Ni, Zn, Cu, Mn) type ferrites produced by thermal decomposition at 700 and 1000 °C were studied. The thermal analysis revealed that the ferrites are formed at up to 350 °C. After heat treatment at 1000 °C, single-phase ferrite nanoparticles were attained, while after heat treatment at 700 °C, the CoFe2O4 was accompanied by Co3O4 and the MnFe2O4 by α-Fe2O3. The particle size of the spherical shape in the nanoscale region was confirmed by transmission electron microscopy. The specific surface area below 0.5 m2/g suggested a non–porous structure with particle agglomeration that limits nitrogen absorption. By heat treatment at 1000 °C, superparamagnetic CoFe2O4 nanoparticles and paramagnetic NiFe2O4, MnFe2O4, CuFe2O4 and ZnFe2O4 nanoparticles were obtained.

Synthesis and characterization of Mg2+ substituted MnFe2O4 nanoparticles for supercapacitor applications

Supercapacitors have been intensively explored as one of the most promising energy storage devices, because of their unique advantages. Mixed spinel ferrites have been widely used in electrochemical (EC) devices owing to their benefits, including extraordinary chemical stability and significant surface area. Though, the EC properties of transition metals are sturdily dependent on their physicochemical properties. The properties of nanoparticles are greatly influenced by a variety of factors, including their composition and shape. The thermal stability of the Mg0.5Mn0.5Fe2O4 nanoparticles is confirmed by TGA/DTA/DSC measurements. The cyclic voltammetry measurement was done using a three-electrode system to evaluate the prepared electrode's EC properties. The EC measurement of synthesized materials was evaluated in 1 M of KOH electrolyte. At a 0.5 A/g current density, the Mg0.1Mn0.9Fe2O4 electrodes had the highest specific capacitance of 226.4 Fg-1, compared to Mg0.3Mn0.7Fe2O4, Mg0.4Mn0.6Fe2O4, and Mg0.5Mn0.5Fe2O4 electrodes. These data demonstrate that the Mg0.1Mn0.9Fe2O4 electrodes developed are excellent EC agents. Because of the crucial effect of particle sizes and surface coordinating environments, nanoscale spinel ferrite particles showed several promising uses when compared to bulk counterparts.

Dye degradation and antimicrobial applications of manganese ferrite nanoparticles synthesized by plant extracts

Manganese Ferrite nanoparticles are synthesized using biological agents as a fuel by the self-combustion method using ginger root/cardamom seeds extract. The green synthesis of manganese ferrite is eco-friendly, inexpensive, and easy to produce in large-scale solid materials. Plant extract mediated MnFe2O4 nanoparticles are characterized by various techniques to analyse the size, structure, crystallinity, and photocatalytic properties. Energy-dispersive X-ray spectroscopy analysis confirmed the presence of manganese, iron, and oxygen elements. The X-ray diffraction pattern showed spinel structure and was endorsed by Fourier Transform Infrared Spectra (FTIR). The formation of porous structure and the morphology of prepared materials are studied by Scanning Electron Microscopy (SEM) images. This type of structure is useful for the photocatalytic dye degradation of Methylene Blue in visible light under the influence of various concentrations of H2O2. Fenton type effect is observed in visible spectrophotometer for dye degradation. The effects of MnFe2O4 ginger root (MnG) (100 μg) and MnFe2O4 cardamom (MnC) (100 μg) are tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis on Mueller Hinton agar plates using well diffusion assay, and the zones of inhibition are measured.

Synthesis and Antibacterial Activity of Manganese-Ferrite/Silver Nanocomposite Combined with Two Essential Oils.

The antimicrobial activity of metal nanoparticles obtained by biogenic routes has been extensively reported. However, their combined use with other antimicrobial formulations, such as essential oils, remains scarcely explored. In this work, a manganese-ferrite/silver nanocomposite (MnFe2O4/Ag-NC) was synthesized in a two-step procedure: first, MnFe2O4 nanoparticles were produced by a coprecipitation method, followed by in situ biogenic reduction of silver ions using Galega officinalis. MnFe2O4/Ag-NC was characterized using transmission electron microscopy (TEM), scanning electron microscopy equipped with an energy dispersive X-ray analyzer (SEM-EDX), and a vibrating sample magnetometer (VSM-SQUID). The antibacterial activity if MnFe2O4/Ag-NC was evaluated against Pseudomonas syringae by determining its minimum inhibitory concentration (MIC) in the presence of two essential oils: eucalyptus oil (EO) and garlic oil (GO). The fractional inhibitory concentration (FIC) was also calculated to determine the interaction between MnFe2O4/Ag-NC and each oil. The MIC of MnFe2O4/Ag-NC was eightfold reduced with the two essential oils (from 20 to 2.5 µg mL−1). However, the interaction with EO was synergistic (FIC: 0.5), whereas the interaction with GO was additive (FIC: 0.75). Additionally, a time-kill curve analysis was performed, wherein the MIC of the combination of MnFe2O4/Ag-NC and EO provoked a rapid bactericidal effect, corroborating a strong synergism. These findings suggest that by combining MnFe2O4/Ag-NC with essential oils, the necessary ratio of the nanocomposite to control phytopathogens can be reduced, thus minimizing the environmental release of silver.

Synthesis of conjugated polyvinyl chloride derivative coupled MnFe2O4 nanoparticles as a magnetic visible-light photocatalyst

MnFe2O4 is a potential magnetic visible-light photocatalyst, but its photocatalytic efficiency is badly restricted by the high recombination rate of its photogenerated electrons and holes. This work used conjugated polyvinyl chloride derivative (CPVC) to couple MnFe2O4 to boost its photocatalytic efficiency. CPVC/MnFe2O4 nanocomposites with an n-p heterojunction structure were prepared by an easily implementable three-step approach. When applied to the photocatalytic reduction of aqueous hexavalent chromium (Cr(VI)) with the help of visible-light (λ > 420 nm), the CPVC/MnFe2O4 nanocomposite synthesized under the optimized conditions (CPVC/MnFe2O4-2) demonstrated not only superior photocatalytic activity than MnFe2O4 nanoparticles and many other recently reported visible-light photocatalysts, but also remarkable durability. In addition, CPVC/MnFe2O4-2 also had strong magnetism and could be effectively separated from the solution by attraction with a magnet. According to the results of structure and photoelectrochemical characterization, the superior photocatalytic activity of CPVC/MnFe2O4-2 largely results from its bigger specific surface area and improved photogenerated charge separation and transfer capability. This work suggests that a new cost-effective, efficient and magnetically recoverable visible-light photocatalyst may be developed by coupling MnFe2O4 with CPVC.

Efficient One-Pot Synthesis of 1,4-Dihydropyridines Catalyzed by Magnetic MnFe2O4 Nanoparticles.

The efficient one-pot synthesis of some 1,4-dihydropyridines is described by a condensation reaction of some aldehyde derivatives, ethyl acetoacetate and ammonium acetate in the presence of superparamagnetic manganese ferrite nanoparticles at 80 °C. The advantages of this protocol include selectivity, high purity of the products, excellent yields, short reaction times, ease of processing, and environmentally friendly conditions for the synthesis of 1,4-dihydropyridines. In addition, the catalyst can be recovered and reused in multiple runs without significantly reducing the product yield.

Design and Development of Gold-Loaded and Boron-Attached Multicore Manganese Ferrite Nanoparticles as a Potential Agent in Biomedical Applications.

Early diagnosis and effective treatment of cancer are significant issues that should be focused on since it is one of the most deadly diseases. Multifunctional nanomaterials can offer new cancer diagnoses and treatment possibilities. These nanomaterials with diverse functions, including targeting, imaging, and therapy, are being studied extensively in a way that minimize overcoming the limitations associated with traditional cancer diagnosis and treatment. Therefore, the goal of this study is to prepare multifunctional nanocomposites possessing the potential to be used simultaneously in imaging such as magnetic resonance imaging (MRI) and dual cancer therapy such as photothermal therapy (PTT) and boron neutron capture therapy (BNCT). In this context, multi-core MnFe2O4 nanoparticles, which can be used as a potential MRI contrast agent and target the desired region in the body via a magnetic field, were successfully synthesized via the solvothermal method. Then, multi-core nanoparticles were coated with polydopamine (PDA) to reduce gold nanoparticles, bind boron on the surface, and ensure the biocompatibility of all materials. Finally, gold nanoparticles were reduced on the surface of PDA-coated MnFe2O4, and boric acid was attached to the hybrid materials for also possessing the ability to be used as a potential agent in PTT and BNCT applications in addition to being an MRI agent. According to the cell viability assay, treatment of the glioblastoma cell line (T98G) with MnFe2O4@PDA-Au-BA for 24 and 48 h did not cause any significant cell death, indicating good biocompatibility. All analysis results showed that the developed MnFe2O4@PDA-Au-BA multifunctional material could be a helpful candidate for biomedical applications such as MRI, PTT, and BNCT.

Quercetin loading on mesoporous magnetic MnFe2O4@ hydroxyapatite core-shell nanoparticles for treating cancer cells

Despite the availability of various nanostructure for cancer cells therapeutic, caring hydrophobic drugs to the target site is still one of the great challenges in chemotherapy. In this study, quercetin (QC), a poorly water-soluble natural anticancer agent, was used as a model drug to evaluate the efficiency of mesoporous magnetic MnFe2O4 core-shell nanocomposite particles. A simple co-precipitation method was employed to synthesis MnFe2O4 as core of nanostructure. Then, the obtained MnFe2O4 nanoparticles were coated with mesoporous hydroxyapatite (HA) shell as a new perspective for drug loading. The magnetic mesoporous nanostructure had specific surface area and mean pore size of 165.44 m2/g and 11.561 nm, respectively. In QC loading process, the MnFe2O4@HA nanostructure demonstrated loading capacity of 123 µg/mg with pH-depended release manner. In compare with free QC, loaded QC on MnFe2O4 core-shell nanocomposite particles exhibited 55% higher antioxidant activities against free 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. Moreover, comparative in-vitro anticancer studies on Michigan cancer foundation (MCF)-7 cells, breast cancer cell line, demonstrated more reduction in number of viable cells (35.6%) using loaded QC than that of free QC (50.76%), suggesting improvement in the solubility of QC by loading onto mesoporous magnetic nanocomposite particles compared to free QC.

Folate-Targeted PEGylated Magnetoliposomes for Hyperthermia-Mediated Controlled Release of Doxorubicin.

Doxorubicin (DOX) is a chemotherapeutic agent commonly used for the treatment of solid tumors. However, the cardiotoxicity associated with its prolonged use prevents further adherence and therapeutic efficacy. By encapsulating DOX within a PEGylated liposome, Doxil® considerably decreased DOX cardiotoxicity. By using thermally sensitive lysolipids in its bilayer composition, ThermoDox® implemented a heat-induced controlled release of DOX. However, both ThermoDox® and Doxil® rely on their passive retention in tumors, depending on their half-lives in blood. Moreover, ThermoDox® ordinarily depend on invasive radiofrequency-generating metallic probes for local heating. In this study, we prepare, characterize, and evaluate the antitumoral capabilities of DOX-loaded folate-targeted PEGylated magnetoliposomes (DFPML). Unlike ThermoDox®, DOX delivery via DFPML is mediated by the heat released through dynamic hysteresis losses from magnetothermal converting systems composed by MnFe2O4 nanoparticles (NPs) under AC magnetic field excitation—a non-invasive technique designated magnetic hyperthermia (MHT). Moreover, DFPML dismisses the use of thermally sensitive lysolipids, allowing the use of simpler and cheaper alternative lipids. MnFe2O4 NPs and DFPML are fully characterized in terms of their size, morphology, polydispersion, magnetic, and magnetothermal properties. About 50% of the DOX load is released from DFPML after 30 min under MHT conditions. Being folate-targeted, in vitro DFPML antitumoral activity is higher (IC50 ≈ 1 μg/ml) for folate receptor-overexpressing B16F10 murine melanoma cells, compared to MCF7 human breast adenocarcinoma cells (IC50 ≈ 4 μg/ml). Taken together, our results indicate that DFPML are strong candidates for folate-targeted anticancer therapies based on DOX controlled release.