The laser properties of Nd:LuYLaVO4 mixed crystal have been investigated in this study. To the best of our knowledge, the operations of passively and actively Q-switched lasers are realized by employing the Nd:LuYLaVO4 crystal as the gain medium, for the first time. In the passively Q-switched laser experiment, a pulse duration of 1.53 ns and a single pulse energy of 12.37 μJ are obtained, and the counterparts of the actively Q-switched laser experiment are 24.80 ns and 85 μJ, respectively. The results indicate the great potentials of Nd:LuYLaVO4 mixed crystals in pulsed laser applications.