In the present study, a strain-based approach called the modified maximum tangential strain criterion has been developed for evaluating size effect on the mixed-mode fracture resistance of quasi-brittle materials. This approach relies on the generalized maximum tangential strain criterion, which considers the singular (K) and the first non-singular (T) terms of Williams series expansion. Furthermore, as an important and size-dependent parameter in the proposed criterion, a new formulation is presented to calculate the critical distance (rc). The predictions of the new criterion are compared not only with the available experimental data, but also with the results estimated by another size effect criterion named the modified maximum tangential stress criterion. It is shown that the proposed strain-based criterion is highly capable of estimating the size-dependent mixed-mode fracture behavior of quasi-brittle materials without requiring to compute the other higher order terms.