In the Netherlands, primary healthcare professionals will increasingly be required to manage and optimize their treatment for patients with dementia. Although many initiatives have been designed over the past years, current dementia care is still suboptimal because, among others, fragmentation of care, lack of expertise and sufficient training, limited individuation to patients’ needs, and limited exchange between general and specialized care. DementiaNet - a collaborative care approach - aims to reduce the burden of the disease on individuals, health care services, and society. Since accessibility of services varies locally, we tailor the approach to each local network based on services, healthcare professionals and resources available. With DementiaNet we aim to work towards high quality, network-based care that encourages collaboration, enhances knowledge and skills, and stimulates quality improvement. These networks are organized on a local level, including healthcare professionals from preferably medical, care and social disciplines as well as the person with dementia and informal carers. Via practice facilitation, we support primary healthcare professionals through the organization, implementation and maintenance of local networks following a stepwise, tailor-made approach including network-based care, clinical leadership, quality improvement cycles, interprofessional practice-based training, and communication support tools. Alongside the healthcare innovation, a longitudinal mixed methods multiple case study is designed to evaluate innovation and effectiveness. All DementiaNet networks serve as a case and are followed over time. The first generation of DementiaNet currently includes 18 networks. These networks vary in size, represented disciplines, quality of care, initial activities, goals and strength of collaboration due to local circumstances. The ongoing research will identify merits, barriers and facilitators for our approach in increasing quality of care and improving outcomes for patient, carer, health service and society. Initial experiences and results show that DementiaNet can lead to quality improvement, as a tailor-made integrated care innovation, that directly built on the differences and needs as seen in daily clinical dementia practice. Primarily, we aim to enhance dementia care, yet, the basics and activities of DementiaNet are general and might therefore serve as a model towards enhanced collaboration and quality improvement for other populations.