Airfoil-type cracks with curved surfaces and sharp tips are frequently encountered in modern engineering applications and the aerospace industry. However, such cracks significantly threaten structures due to stress concentration and further cause damage. This study investigates the theoretical analysis and failure prediction of airfoil-type cracks within thermoelectric coupling materials under the interaction of remote mechanical loads, heat flux and electric current density. By employing complex variable theory, conformal mapping methods, and the analytic continuation theorem, the full-field stress and stress intensity factors of an airfoil-type crack were determined under three different loading conditions. The results indicate that when the airfoil-shaped crack tip is subjected to horizontal compression, vertical tensile mechanical load, and both heat flux and current density parallel to the crack, the crack tip would reach a dangerous state. Additionally, the full-field stress distribution reveals stress concentration around the crack tip, which explains variations in SIFs under different external forces and shape factors. Four critical situations suppressing crack propagation under mixed loading conditions are proposed. Furthermore, using an acrylic plate and bismuth telluride alloy as examples, the critical values of external loading for the mixed-mode fracture are determined based on the strain energy density criterion. These critical values can be used to predict failure initiation, thus reducing the risk of structural failure due to airfoil cracks within thermoelectric coupling materials.