Mixed Ligand Nickel Complex Research Articles

Unveiling Optical Nonlinearity: Exploring Nickel‐Curcumin Complexes through Z‐Scan and Degenerate Four Wave Mixing Techniques

AbstractTwo Curcumin (Cur) based mixed ligand complexes of Nickel have been investigated for their optical nonlinearity (NLO). Physicochemical characterization of two nickel precursors and their interaction with curcumin produced two molecules, namely Ni(C3S5)(Cur).2H2O (abbreviated as NiThCur) and NiCl(Cur)(PPh3) (abbreviated as NiTppCur). Additionally the Conceptual‐Density‐Functional‐Theory (CDFT) studies were performed. CDFT‐based optimization parameters of both molecules are theoretically interpreted. HOMO‐LUMO energy gap of NiThCur and NiTppCur were calculated 1.474 eV and 2.744 eV respectively. Both molecules demonstrated good NLO activities, studied by a Z‐scan approach and additionally with a Differential Four wave Mixing (DFWM) technique. Preliminarily investigations showed that the molecules can be potential optical limiters (OL). These studies divulge the exhibition of a 3‐photon absorption (3PA) mechanism by the synthesized molecules. NLO absorption 3PA coefficient (γ) value of 1.34×10−24 m3/W2, third‐order optical susceptibility (χ(3)) value of 1.543×10−11 esu, and the figure of merit 6.64×10−14 esu was observed for the NiThCur complex and γ=3.61×10−24 m3/W2, χ(3)=1.521×10−11 esu, and FoM=5.61×10−14 esu for NiTppCur with Z‐scan (γ and χ(3)) and DFWM methods, respectively. Normalized transmittance (NT) exhibited a decrease to 78.5 % from 100 % in NiThCur and to 69.5 % in NiTppCur. Optical limiting calculations are also presented.

Mixed-Ligand Complexes of Nickel(II) with 1-(5-Halogen-2-pyridylazo)-2-hydroxy-4-mercaptophenol and Aminophenols and Their Applications

Mixed-Ligand Complexes of Nickel(II) with 1-(5-Halogen-2-pyridylazo)-2-hydroxy-4-mercaptophenol and Aminophenols and Their Applications

Mixed ligand complexes of nickel (ii): Synthesis and bio medicinal studies

Mixed ligand nickel (II), complexes of 2, 2 bipridyle and thioamides of 2-aminopyridine, 2-aminoadinine, 2-aminoguanine and 2-aminocytocine were prepared. The success of synthesis was confirmed through physical and spectral characterization on the basis of IR and NMR spectroscopy, antimicrobial and antitumour studies. The synthesized compounds were found to be active against the tested three bacterial strains (Pseudomanas auruginosa, Klebseila pneumonia and Staphylococcus aureus), two fungal strains (Aspergillus flavus and Aspergillus nigar) and antitumour activity against MCF-7 (Human breast adenocarcinoma) cell line.

Synthesis, characterization, docking and antimicrobial activity studies of binuclear Co(II) and Ni(II) complexes of bis aroylhydrazone and phenanthroline

ABSTRACT. Schiff base (HL) N1,N3-bis(4-(methylthio)benzylidene)-5-nitrobenzene-1,3-dihydrazide (HL) has been prepared from condensation of 4-(methyl thio)benzaldehyde with 5-nitrobenzene-1,3-dihydrazide. Binucleated mixed ligand complexes of nickel(II) ([Ni2(L)(dmphen)2]Cl2, [Ni2(L)(phen)2]Cl2) and cobalt(II) ([Co2(HL)(dmphen)2]Cl2, [Co2(HL)(phen)2]Cl2) complexes have been synthesized from Schiff base (HL) and 1,10-phenanthroline/2,9-dimethyl-1,10-phenanthroline. The synthesized compounds have been characterized by elemental analysis, 1H-NMR, 13C-NMR, FT-IR, UV-Visible, magnetic moment, SEM, powder X-ray diffraction and molar conductivity measurements. Further, the Schiff base and its metal complexes have been investigated for fluorescence activity and molecular docking studies. In addition, Schiff base and its metal complexes were screened for antimicrobial activity against bacteria: Escherichia coli, Bacillus subtilis and fungi: Sclerotium rolfsii and Macrophomina phaseolina.
 
 KEY WORDS: Growth inhibitors, Ternary complex, Tuberculosis, Fluorescence activity, Crystal system
 
 Bull. Chem. Soc. Ethiop. 2021, 35(3), 499-511.
 DOI: https://dx.doi.org/10.4314/bcse.v35i3.3

Synthesis, Characterization and Luminescent Properties of Mixed-Ligand Nickel Complexes for Opto-Electronic Application

This paper reports the synthesis of a mixed ligand nickel complexes as an emissive layer in organic light emitting diode applications. Synthesized ligand and nickel complexes were characterized by Fourier transform infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, mass spectroscopy, x-ray powder diffraction and scanning electron microscopy. This compound shows good thermal stability and film forming properties. Optical properties have been studied by UV–vis and photoluminescence (PL). Frontier molecular orbital theory energy levels of these compounds were demonstrated using density functional theory calculations. Photoluminescence (PL) emission peaks of complexes (1) and (2) show at 596 nm and 581 nm in solid state, respectively. The structure of the fabricated multi-layered device is: ITO/αNPD(300 A)/(1)(350 A)/BCP(60 A)/Alq3(280 A)/LiF(10 A)Al(1500 A) and ITO/αNPD(300 A)/(2)(350 A)/BCP(60 A)/Alq3(280 A)/LiF(10 A)Al(1500 A). Electroluminescence emission of devices (1) and (2) containing nickel complexes as the emissive layer emit at 568 nm and 561 nm, respectively. Commission Internationale de l’Eclairage chromaticity colour coordinates of devices (1) and (2) were found to be x = 0.426, y = 0.425 and x = 0.473, y = 0.447, respectively, which emits an orange colour. These results show that these nickel complexes can act as a promising emissive layer in opto-electronic applications as strong electroluminescent materials.

Ternary nickel(II) complexes with histidine and glycylglycine in solution: Thermodynamic approach

Potentiometric study on mixed-ligand complexes of nickel(II) ion with histidine (His) and glycylglycine (GG) has been carried out in aqueous solution at 298.15 K and the ionic strength of I = 0.5 (KNO3). Based on a comparative analysis of the thermodynamic data on complex formation, possible coordination modes of dipeptide and amino acid residues in mixed ligand complexes are discussed.

Nickel(II)-PPh3 complexes of substituted benzophenone thiosemicarbazones: Electrochemistry, structural analysis, and antioxidant properties

New mixed ligand complexes of nickel(II) were synthesized by using dibasic H/5-bromo-/5-chloro-/4-hydroxy-2-hydroxybenzophenone-thiosemicarbazones (L1–4 H2) and [Ni(PPh3)2Cl2]. The ligands and complexes were characterized by cyclic voltammetry, infrared, 1H and 31P NMR spectroscopy techniques. Crystallographic analyses of the 5-bromo-substituted (2) and 5-chloro-substituted (3) complexes as representatives were performed and so confirmed the ONS chelate structure and presence of PPh3 as co-ligand in the complexes. To reveal the antioxidant properties of the compounds, TEAC values (by CUPRAC method) were determined along with free radical-scavenging activity (by DPPH method). The compounds bearing 4-hydroxy substituent, L4 H2 and complex 4 were the most effective compounds. The relationship between structure and antioxidant capacity in the context of benzophenone substituents and nickel(II) center was evaluated. Electrochemical results revealed that all complexes displayed metal-centered and ligand-centered redox processes. The antioxidant capacities of complexes were well correlated to electrochemical parameters.

Syntheses of Coordination Compounds of (±)-2-Amino-3-(4-Hydroxyphenyl)Propionic Acid, Mixed Ligand Complexes and Their Biological Activities

Coordination compounds of (±)-2-amino-3-(4-hydroxyphenyl) propionic acid and their mixed ligand complexes with 1,10-phenantroline were synthesized, characterized using electronic and infrared spectral analyses and magnetic susceptibility. The compounds were evaluated for antimicrobial and antioxidant activities. Four different assays were applied for evaluating antioxidant capacity of the compounds. The results obtained indicated a diametric square planar geometry for both cobalt (±)-2-amino-3-(4-hydroxyphenyl) propionic acid complex and its mixed ligand complex. It was suggested that for the binary cobalt(II) complex, the phenolic substituent coordinated with neighbouring central metal ions. However, for the ternary cobalt(II) complex it was suggested it was deprotonated. Octahedral geometry was proposed for both copper complexes. Square planar geometry was indicated for the nickel (±)-2-amino-3-(4-hydroxyphenyl) propionic acid complex and a mixture of square planar and octahedral geometry for the nickel mixed ligand complex. The cobalt mixed ligand complex elicited the highest activity for all the antioxidant assays. In most cases the binary complexes exhibited better antimicrobial activities relative to their ternary counterparts.

Synthesis and structural characterization of mixed ligand complexes of nickel(II) with 1,8-diaminonaphthalene and 1-cyano-1-carboethoxyethylene-2,2-dithiolate

Synthesis and structural characterization of mixed ligand complexes of nickel(II) with 1,8-diaminonaphthalene and 1-cyano-1-carboethoxyethylene-2,2-dithiolate

Synthesis, crystal structure, interaction with DNA, and cytotoxicity in vitro of a new mixed ligand-nickel complex: [Ni(DBMA)(en)(H2O)3]·3H2O

A mixed ligand-nickel complex of formula [Ni(DBMA)(en)(H2O)3]·3H2O, where DBMA = 2,2-dibenzyl malonic acid, en = ethylenediamine, has been synthesized and characterized by elemental analysis, IR, and single-crystal X-ray diffraction. The unit cell parameters for the complex are a = 16.0214(16) Å, b = 10.0801(10) Å, c = 15.4024(15) Å, β = 108.488(2)°, V = 2359.074(40) Å3, Z = 4, space group P2(1)/c. The crystal system of the complex is monoclinic. Thermal stability of the water cluster by thermogravimetric analysis has been studied. Gel electrophoresis assay demonstrated the ability of the complex to cleave pBR322 plasmid DNA. The binding of the complex with HeLa cell DNA (HC-DNA) has been investigated by fluorescence spectra. Value of IC50 calculated for the complex shows that the complex exhibits good cytotoxicity against HeLa and KB cell lines.

New nickel mixed-ligand complex containing 2-aminopyrimidine and 5-bromosalicylaldehyde with a one-dimensional hydrogen bonded structure

The compound [Ni(PymNH2)2(5-BrSal–H)2]n·2dmf (PymNH2=2-aminopyrimidine, 5-BrSal=5-bromosalicylaldehyde, dmf=dimethylformamide) has been synthesized and characterized by elemental analysis, X-ray crystallography and infrared spectroscopy. Mutual trans arrangement of the 2+2 organic ligands that octahedrally coordinate one nickel centre enables intramolecular H-bonds to further stabilize the neutral molecule and vice versa. In the crystal lattice, each PymNH2 ring forms a dimer with its inversion-related counterpart via a hydrogen atom of the amino group and the non-coordinated ring nitrogen. The packing motif of the self-complementary hydrogen bonded PymNH2 dimers, which form chains of the complex molecules, is the structure-determining factor in the present study. Dmf molecules of crystallization are accommodated on both sides of the dimers.

Nickel complexes of some thiosemicarbazones: Synthesis, structure, catalytic properties and cytotoxicity studies

Reaction of salicylaldehyde thiosemicarbazone (H2L1), 2-hydroxyacetophenone thiosemicarbazone (H2L2) and 2-hydroxynaphthaldehyde thiosemicarbazone (H2L3) with Ni(ClO4)2·6H2O afforded dimeric complexes of type [{Ni(L)}2]. Reaction of these complexes with triphenylphosphine (PPh3), pyridine (py) and 4,4′-bipyridine (bpy) has yielded complexes of type [Ni(L)(PPh3)], [Ni(L)(py)] and [{Ni(L)}2(bpy)], respectively, which have also been obtained from reaction of the thiosemicarbazones with Ni(ClO4)2·6H2O and PPh3 or pyridine or 4,4′-bipyridine. Structures of the [{Ni(L)}2] complexes have been optimized by DFT calculations. Crystal structures of [Ni(L2)(PPh3)], [Ni(L2)(py)] and [{Ni(L1)}2(bpy)] have been determined. In all these complexes thiosemicarbazone is coordinated to nickel as ONS-donor. All these complexes show characteristic 1H NMR spectra and intense absorptions in the visible and ultraviolet region. Cyclic voltammetry on the complexes shows one irreversible oxidation on the positive side of SCE, and one irreversible reduction on the negative side. The mixed-ligand nickel complexes are found to be efficient catalysts for Heck type C–C coupling reactions. In vitro cytotoxicity screenings of the six mononuclear nickel complexes have been also carried out in a human tumor cell lines, viz. breast carcinoma cell line (MCF-7). [Ni(L3)(py)] shows the lowest LD50 value. An apoptosis study in MCF-7 with all the complexes confirms that at concentrations near LD50 they induce apoptosis.

Synthesis, characterization and DNA cleavage activity of nickel(II) adducts with aromatic heterocyclic bases

Mixed ligand complexes of nickel(II) with 2,4-dihydroxyacetophenone oxime (DAPO) and 2,4-dihydroxybenzophenone oxime (DBPO) as primary ligands, and pyridine (Py) and imidazole (Im) as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II) complexes.

Mixed ligand complexes of nickel(II) and cerium(III) ions with 4-(-3-methoxy-4-hydroxybenzylideneamino)-1, 3-dimethyl-2,6-pyrimidine-dione and some nitrogen/oxygen donor ligands

Mononuclear mixed ligand complexes of Ni(II) and Ce(III) with 4-(-3-methoxy-4-hydroxybenzylideneamino)-1,3-dimethyl-2,6-pyrimidine-dione, 2-aminopyridine and 8-hydroxyquinoline have been prepared. The elemental analysis, molar conductance, spectral (IR, mass and solid reflectance), magnetic moment measurements and thermal study were utilized to investigate the coordination behavior. All metal complexes have metal-to-ligand ratios of 1:1:1 and the modes of bonding are consistent with N- and O-donation suggesting monomeric octahedral and square planar structures. The thermal behavior of these complexes was investigated and the thermal decomposition pathways postulated. The activation thermodynamic parameters, E*, ΔH*, ΔS* and ΔG* for the different thermal decomposition steps of the complexes were calculated using the Coats-Redfern equation. Antibacterial and antifungal properties of the metal complexes have also been examined against Staphylococcus aureus (ATCC 25923), Streptococcus pyogenes (ATCC 19615), Pseudomonas fluorescens (S 97), Pseudomonas phaseolicola (GSPB 2828), Fusarium oxysporum and Aspergillus fumigatus. The highest antimicrobial activity was observed for the Ce(III) complex, [CeL(8-Oqu)(NO3)2]·1½H2O.

Synthesis and structural characterization of mixed ligand complexes of nickel(II) with 1-cyano-1-carboethoxyethylene-2,2-dithiolate and some nitrogen donors

Mixed ligand complexes of NiII ion with 1-cyano-1-carboethoxyethylene-2,2-dithiolate (CED2−[S2C = C (CN)(COOC2H5)]2−) as a primary ligand and o-phenylenediamine (OPD), pyridine (py), α-picoline (α-pic), β-picoline (β-pic) or γ-picoline (γ-pic) as secondary ligands have been isolated and characterized on the basis of analytical data, molar conductance, magnetic susceptibility, electronic and infrared spectral studies. The molar conductance data reveal that the complexes have 1:1 electrolytic nature in DMF solution. Magnetic and electronic spectral studies suggest distorted octahedral stereochemistry around NiII ion in its complexes. Infrared spectral studies suggest bidentate chelating behaviour of CED2− ion and OPD while other ligands show unidentate behaviour in their complexes.

Spectroscopic, viscositic and electrochemical studies of DNA interaction with a novel mixed-ligand complex of nickel (II) that incorporates 1-methylimidazole and thiocyanate groups

A novel mixed-ligand nickel(II) complex that contains 1-methylimidazole and thiocyanate, Ni(NCS) 2(Mim) 4 (Mim = 1-methylimidazole), was synthesized and its structure was determined by X-ray crystallography, IR spectrum and elemental analysis, etc. Its DNA-binding properties were studied by electronic absorption spectral, viscositive and electrochemical measurements. The absorption spectral and viscositive results suggest that the nickel(II) complex binds to DNA via partial intercalation. The addition of DNA results in the decrease of the peak current of the nickel(II) complex proved their interaction. The slight differences of peak profiles and electrochemical parameters between free and DNA-bound Ni(NCS) 2(Mim) 4 showed the formation of an electrochemical inactive complex between Ni(NCS) 2(Mim) 4 and DNA. The binding site and binding constant of the complex to DNA were determined by electrochemical titration method.

Synthesis, spectroscopic characterization and crystal structure of mixed ligand Ni(II) complex of N-4-diethylaminosalicylidine-N′-4-nitrobenzoyl hydrazone and 4-picoline

A novel mixed ligand nickel complex [NiLB] [H2L-N-4-diethylaminosalicylidine-N′-4-nitrobenzoyl hydrazone and B-4-picoline] has been synthesized and characterized by elemental analysis, IR spectrum, UV-Vis spectrum and structure has been confirmed by single crystal X-ray structure analysis. The crystal structure reveals that the complex adopts distorted square planar structure with ONO donor atoms of primary ligand and N donor atom of the secondary ligand 4-picoline.

Mixed ligand complexes of nickel-, copper- and zinc(II) with 5-chloro(or bromo )salicylaldehyde and hydroxyaromatic aldehydes or ketones

Mixed ligand complexes of the types [M(L)(L')] and [Ni(L)(L')(H 2 O) 2 ] (where M = Cu I I , Zn I I ; HL = 5-chlorosalicylaldehyde, HL' = salicylaldehyde, 2-hydroxyacetophenone or 2-hydroxypropiophenone; HL = 5-chloro(or bromo)salicylaldehyde, HL' = 2-hydroxy-l-naphthaldehyde or 2-hydroxybenzophenone) have been synthesized and characterized by conductances, TLC, thermal analyses, magnetic moments, IR, 1 H NMR and electronic spectral studies.

Synthesis and Crystal Structure of Mixed-Ligand Ni(II) Complex of N-(1-Phenyl-3-methyl-4-benzylidene-5-pyrazolone) p-Nitrobezoylhydrazide and Pyridine

A novel mixed-ligand nickel complex, [Ni(PMBP—PNH) (Py)3], [PMBP—PNH=N-(1-phenyl-3-methyl-4-benzylidene-5-pyrazolone) p-nitrobezoylhydrazide; Py = pyridine], has been synthesized by the hydrothermal method and characterized by elemental analysis, IR spectrum, thermal analysis, and single-crystal X-ray diffraction. The X-ray diffraction reveals that the nickel (II) ion in the title complex is in a slightly distorted octahedral arrangement of the ONO donor atoms of primary ligand PMBP-PNH and three N-donor atoms in the secondary ligand pyridine.

Novel Ni(II) Mixed Ligand Complex Modified Electrode: Catalytic Effect on Anodic Oxidation of Phenol

AbstractCyclic voltammetry, using graphite paste electrode (GPE) and chemically modified GPE with Ni(II) mixed ligand complex (MGPE), is described for sensing and detoxification of phenol. A novel mixed ligand complex of nickel with 1,4,8,11‐tetraaza cyclotetradecane (cyclam) and thiocyanate in the molar ratio of 1 : 2 : 5 is synthesized and characterized by spectroscopic and electrochemical studies. The Ni(II)‐cyclam‐thiocyanate complex behaves as a fast electron‐transfer mediator, as nickel ions exist in higher oxidation state of Ni(III) on applying a potential of 1.25 V (vs. Ag/AgCl), which catalyses the oxidation of the target species. The mixed ligand complex, when incorporated in the graphite paste electrode, is sensitive to detect phenol as low as 10 μg/L in solution. The catalytic effect of the Ni(II)‐cyclam‐thiocyanate complex enhanced many folds the oxidation of phenol compared to GPE. The technique has potential for sensing/monitoring and detoxification of phenol released in the ecosystem from polluting industries.