Abstract
Coordination compounds of (±)-2-amino-3-(4-hydroxyphenyl) propionic acid and their mixed ligand complexes with 1,10-phenantroline were synthesized, characterized using electronic and infrared spectral analyses and magnetic susceptibility. The compounds were evaluated for antimicrobial and antioxidant activities. Four different assays were applied for evaluating antioxidant capacity of the compounds. The results obtained indicated a diametric square planar geometry for both cobalt (±)-2-amino-3-(4-hydroxyphenyl) propionic acid complex and its mixed ligand complex. It was suggested that for the binary cobalt(II) complex, the phenolic substituent coordinated with neighbouring central metal ions. However, for the ternary cobalt(II) complex it was suggested it was deprotonated. Octahedral geometry was proposed for both copper complexes. Square planar geometry was indicated for the nickel (±)-2-amino-3-(4-hydroxyphenyl) propionic acid complex and a mixture of square planar and octahedral geometry for the nickel mixed ligand complex. The cobalt mixed ligand complex elicited the highest activity for all the antioxidant assays. In most cases the binary complexes exhibited better antimicrobial activities relative to their ternary counterparts.
Highlights
Octahedral geometry was proposed for both copper complexes
Square planar geometry was indicated for the nickel (±)-2-amino-3-(4-hydroxyphenyl)propionic acid complex and a mixture of square planar and octahedral geometry for the nickel mixed ligand complex
We further propose an octahedral geometry for compounds 3, 4 and 6
Summary
These include coordination compounds, because of their unique properties and broad range of applications; including anti-microbial, -cancer and -oxidant [1] [2] [3] [4]. In combination with a variety of ligands transition metals, form mixed ligand complexes Some of these have been shown to exhibit anti-biotic and -cancer activities [5] [6]. In this regard, extensive applications have been found for 1,10-phenanthroline, a bidentate ligand that forms very stable chelates with many first-row transition metals [7]. The ideally placed nitrogen atoms, of this molecule, along with its rigid planar structure, hydrophobic, electron-poor heteroaromatic, and π-acidic properties, cooperatively make 1,10-phenanthroline a classic chelating ligand, for mixed ligand complexes [7]
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