This paper is concerned with a method for solving vibration problems of a plate of arbitrary shape with free and simply supported mixed edges. In the analysis the exact solution of the equation of motion which includes terms representing the reaction forces of the simply supported edges is applied. The boundary conditions along the edges of arbitrary shape have been satisfied directly by making use of the Fourier expansion collocation method which has been developed by the author on vibration, dynamic response, and wave propagation problems of membranes, plates, and rods with arbitrarily shaped boundaries. The equation for finding the eigenfrequencies of plates of arbitrary shape with free and simply supported mixed edges has been obtained. As applications of the present result, numerical calculations have been carried out for polygonal plates, trapezoidal plates, truncated elliptical plates, and parabolic plates with the mixed edges.