In this study, an investigation is carried out for laminar steady mixed 2D magnetohydrodynamic (MHD) flow of micropolar Casson fluid with thermal radiation over a horizontal circular cylinder with constant surface temperature. In the present study, an investigation is carried out on the effects of physical parameters on Casson fluid non dimensional numbers. The governing nonlinear partial differential equations and the controlling boundary conditions are derived for this case study. Furthermore, these equations are solved numerically using finite difference technique known as Keller Box Method (KBM). The effects of non-dimensional governing parameters, namely Casson parameter, mixed convection parameter, magnetic parameter, radiation parameter on the Nusselt number and local friction coefficient, as well as temperature, velocity and angular velocity are discussed and shown graphically. It is noticed that the local skin friction and the local Nasselt number has decrement behaviors when increasing the values the Casson parameter. But the opposite happens when the mixed convection parameter λ increase. It is found that the results in this study are in good agreement with previous studies. This proves that calculations using KBM method and the chosen step size are accurate enough for this type of problems.