Predictions are reported for mixed convection using various types of nanofluids over forward-facing double steps in a duct. The continuity, momentum and energy equations are discretized and the simple algorithm is applied to link the pressure and flow fields inside the domain. Different types of nanoparticles Al2O3, CuO, SiO2 and ZnO, with different volume fractions in range of 1-4% and different nanoparticles diameter in the range of 20 – 80nm in base fluid (water) were used. Numerical investigations are conducted using finite volume method. In this study, different parameters such as the geometrical specifications (different steps heights in the range of h1= 0.01m-0.04m and h2 = 0.03m-0.06m for FFS) are used. Different Reynolds numbers in the range of 50-2000 (laminar flow) are investigated to identify their effects on the heat transfer and fluid characteristics. The results indicate that SiO2-water has the highest Nusselt number followed by Al2O3-water,Cuo-water and ZnO-water. The Nusselt number increases as the volume fraction increases but it decreases as the nanoparticles diameter increases. The velocity magnitude increases as the density of nanofluids decreases. The recirculation region and the Nusselt number increase as the step height, Reynolds number, and the volume fraction increase.