Sequence-stratigraphic analysis of the Middle Cambrian Highland Peak, Bonanza King, Swasey, and Wheeler formations in the Great Basin refines platform-to-basin correlations and distinguishes local tectonic events from eustasy. This analysis provides a reliable sea-level history through the Ptychagnostus gibbus and Ptychagnostus atavus trilobite intervals and confirms that the Global Stratotype Section and Point (GSSP) at the first appearance datum (FAD) of P. atavus was deposited during an overall sea-level rise. Deposition during the Middle Cambrian Ehmaniella/ Bolaspidella biozones in the western U.S. is represented by two lithologically distinct successions: (1) a poorly fossiliferous, shallow-water, mixed carbonate-siliciclastic succession that is widespread across southern Nevada and southeastern California and (2) a highly fossiliferous, deeper water, fine-grained, siliciclastic succession in central Nevada and western Utah. The deeper water succession was deposited within the fault-controlled House Range Embayment and contains the P. atavus GSSP. Correlation of these disparate successions had been hampered by a lack of high-resolution biostratigraphic data, and limited chemostratigraphy and sequence stratigraphy. In this study, sequence-stratigraphic analysis indicates that the Condor Member of the Highland Peak Formation and the “mixed unit” of the Bonanza King Formation are the shallow-water platform equivalents of the basal Wheeler Formation encompassing the P. gibbus and lower P. atavus zones. The deepening event that is recorded in the P. gibbus Zone represents a major flooding surface that may be used as an important event marker for regional and global correlation. The overlying P. atavus GSSP, however, is within the later stage of transgression and may represent a globally synchronous event that can be correlated from platform to basin.