Balloon Mitral Commissurotomy Research Articles

Percutaneous Balloon Mitral Commissurotomy in Indigenous versus Non-Indigenous Australians

Rheumatic heart disease remains a serious health issue amongst the Australian indigenous population. Percutaneous balloon mitral commissurotomy (PBMC) has become the treatment of choice in patients with symptomatic pure mitral stenosis with favourable valve morphology. There is little published data on the efficacy of PBMC in indigenous Australians. We sought to document differences between indigenous Australians (IA) and non-indigenous Australians (NIA) undergoing percutaneous balloon mitral commissurotomy (PBMC) at The Prince Charles Hospital and Holy Spirit Northside Hospital from 1990 to 2006. PBMC was performed in 327 patients using the Inoue-balloon technique (271 female, 56 male, age +/-15 years (mean+/-S.D.), (range 13-89) between March 1990 and March 2006. The IA population was over represented in this cohort (11% versus an estimated 3.4% of the Queensland population) and comprised the largest non-Caucasian group. Compared with the NIA population they were younger (mean age 36 years (+/-13) versus mean 52(+/-14) years (P<0.05)). Baseline mitral valve area (MVA) was similar in the IA and NIA groups (0.96 cm(2) versus 1.08 cm(2)P=0.9). Mitral valve Echo-score was also similar between the two groups (mean score 7.36 versus 7.52 P=0.8). The IA population had higher pre-procedural mitral valve gradients (14.3 mmHg versus 11.1 mmHg, P<0.05), but less mitral valve calcification. Procedural success was achieved in 91% of both groups. Post procedural MVA (planimetry) was similar (1.98 cm(2) versus 1.84 cm(2)P=0.6), as was percent reduction in mitral valve gradient. Inadequate dilatation was seen in 1 (3%) IA and in 10 (3.6%) of the NIA group. Significant MR was seen in 2 (6%) IA patients and 11 (4%) NIA patients. There were no deaths or strokes or pericardiocenteses in either group. The indigenous population makes up a significant proportion of patients requiring PBMC in Queensland. They present younger and with higher mitral valve gradients. The procedure is safe in both the indigenous and non-indigenous Australian population. Further research is required to establish the long-term efficacy of this procedure in indigenous Australians.

Immediate and Long-Term Results of Mitral Balloon Valvotomy for Restenosis Following Previous Surgical or Balloon Mitral Commissurotomy

Immediate and Long-Term Results of Mitral Balloon Valvotomy for Restenosis Following Previous Surgical or Balloon Mitral Commissurotomy

Effect of Left Atrial Decompression by Percutaneous Balloon Mitral Commissurotomy on the Atrial Electrophysiologic Properties

Background and Objectives:Atrial dilatation contributes to the inducibility of atrial fibrillation (AF) by changing the atrial electrophysiological properties. There has been no report regarding the electrophysiologic data of the left atrium (LA), where the most significant electrophysiological impact might be expected to occur in case of mitral stenosis (MS). We investigated the electrophysiological changes after reduction of the LA pressure in patients who were undergoing percutaneous balloon mitral commissurotomy (PBMC). Subjects and Methods:We studied 26 patients (21 women, age range: 50±12 years) with MS, including 7 sinus rhythm (SR) patients. The effective refractory period (ERP), the monophasic action potential duration (MAPD90), and the conduction time (CT) were measured simultaneously in both atriums at 600, 500, 400 and 300 ms of drive cycle length (DCL). The restitution slope (RS) was also calculated by the S1S2 method. The atrial fibrillation cycle length (AFCL) and dominant frequency (DF) for the cases of AF were also calculated. All the measurements were repeated after PBMC. Results: The mean LA pressure was significantly reduced after PBMC in both the AF and SR patients (17.0±5.5 mmHg vs 10.4±4.0 mmHg, respectively, p<0.01, 17.6±7.1 mmHg vs 9.0±2.8 mmHg, respectively, p<0.01). A significant increase of ERP was observed in the LA after PBMC, but not in the right atrium (RA). The increase of MAPD90 after PBMC was significant in the LA at all the tested DCLs, but not in the RA. The CT was also significantly decreased at all the tested DCLs after PBMC. The RS of the LA decreased from 1.71±0.82 to 0.76±0.33 after PBMC (p=0.056). However, no significant changes of the AFCL or DF after PBMC were observed in the AF group. Conclusion:Chronic atrial stretch altered the atrial electrophysiological milieu, especially in the LA, which was partially reversible in SR patients. This result supports the theoretical basis for the beneficial effects of early intervention to reduce the atrial pressure overload in MS patients. (Korean Circulation J 2007;37:208-215)

Percutaneous transmitral commissurotomy in juvenile mitral stenosis—comparison of long term results of Inoue balloon technique and metallic commissurotomy

To compare the immediate and long term results of percutaneous mitral valvotomy using metallic commissurotome and Inoue balloon in juvenile mitral stenosis. Inoue balloon technique for mitral commissurotomy (IBMC) is well established and carried out worldwide in the treatment of juvenile mitral stenosis. Percutaneous mitral metallic commissurotomy (PMMC) is reported to be a cheaper and effective alternative to balloon mitral commissurotomy. Thirty-three patients aged less than 20 years, who underwent PMMC, were compared with 33 age and sex matched control patients who underwent IBMC. Success of valvotomy, procedure related complications, and follow-up events of the two techniques were compared. Basal echocardiographic and hemodynamic data were similar in both groups. Procedural success was similar in both groups, 31/33. Complications like cardiac tamponade and mitral regurgitation (requiring or not requiring mitral valve replacement) were similar in both groups. On follow-up of more than 3 years, both groups had comparable hemodynamic parameters and restenosis rates. Both IBMC and PMMC are successful in providing relief from severe juvenile mitral stenosis in terms of gain in valve area and reduction in transmitral gradient. Both techniques have similar procedural success and complication rates. The long term follow-up results are comparable at follow-up of more than 3 years.

Open mitral commissurotomy

Closed mitral commissurotomy for rheumatic mitral valve stenosis was used in many tens of thousands of patients with excellent immediate results and durability, many patients having survived more than 20years without reoperations. Gradually, this procedure was displaced by the open commissurotomy which has the advantage of direct visualisation of all valve components with immediate assessment of the anatomical and functional result. Open commissurotomy is applicable even in moderately fibrosed and/or calcified valves and in the presence of intra-atrial thrombus. Its results are well established and have not yet been bettered by less invasive procedures, such as percutaneous balloon mitral commissurotomy.

Immediate and Long-Term Results of Mitral Balloon Valvotomy for Restenosis Following Previous Surgical or Balloon Mitral Commissurotomy

This study compared immediate with long-term results of mitral balloon valvotomy (MBV) in patients who underwent MBV as an initial procedure versus those who underwent repeat MBV. Fifty-six patients who were a mean age of 28 +/- 8.8 years (group A) and had mitral restenosis after surgical or balloon commissurotomy underwent MBV and were compared with 524 patients who were a mean age of 31 +/- 11 years (group B) and underwent MBV as an initial procedure. Prospective data obtained included demographic, hemodynamic, echocardiographic, and clinical follow-up for 0.5 to 15 years after MBV. No deaths or technical failure were encountered after MBV. Mitral regurgitation >2/4 occurred in 1 patient (2%) in group A and in 9 patients (2%) in group B (p = 0.24). Fifty-two of 56 patients (93%) in group A had good immediate results (mitral valve area >or=1.5 cm(2), mitral regurgitation <2/4), as did 504 of 524 patients (96%) in group B (p = 0.4). Actuarial values for freedom from restenosis at 10 years were 58 +/- 7% for group A versus 69 +/- 3% for group B (p = 0.18). Ten-year event-free survival rate was 54 +/- 7% for group A versus 80 +/- 3% for group B (p <0.005). The predictors of event-free survival were age (p = 0.003), echocardiographic score (p <0.0001), and baseline atrial fibrillation (p = 0.01). In conclusion, MBV is safe and provides good immediate results in patients who have restenosis. Long-term results are inferior compared with de novo mitral stenosis but is still satisfactory. More than 50% of patients remained improved at 10 years, thus enabling the operation or reoperation to be deferred.

La commissurotomie mitrale percutanée chez les sujets âgés de 60 ans et plus

Of 745 patients treated by balloon mitral commissurotomy (BMC) between February 1988 and December 2002, 45 were ≥ 60-years old. Immediate and late outcomes in this group (group 1) were compared with those in the patients aged < 60-years (group2). Baseline hemodynamic parameters were comparable in the two groups. Mitral surface area and hemodynamic parameters improved significantly after BMC in group1: mean left atrial pressure fell from 18.76 ± 6.18 to 10.65 ± 4.38 mmHg ( P < 0.001), mean transmitral gradient from 11.03 ± 4.70 to 4.63 ± 2.05mmHg (p < 0.001) and mitral valve area from 0.99 ± 0.22 to 1.88 ± 0.41cm 2 (p < 0.001). Similar significant improvements were seen in group 2. The hemodynamic result was good in 69% of group1 patients. Tamponade occurred in one patient. Mitral regurgitation grade I or II developed in 8 patients and remained stable in 13 patients. These complication rates were comparable to those seen in group 2. In the group 1, a good result was maintained in 60% of patients after 43 ± 23 months of fllow-up. Although restenosis was observed in 40% of patients, functional amelioration was obtained in most of cases. In the group 2, restenosis was observed in 25% of patients. The data from this study suggest that BMC is effective first therapy in patients aged ≥ 60-years with symptomatic mitral stenosis.

Improvement in sympatho-vagal imbalance and heart rate variability in patients with mitral stenosis after percutaneous balloon commissurotomy

Elevated sympathetic nerve activity in patients with mitral stenosis (MS) may be an index of the severity of the disease. Percutaneous mitral balloon commissurotomy (PMBC) is now a standard treatment for many patients with symptomatic MS. We aimed to show the effects of PMBC on autonomic nervous system activity in the patients with MS by heart rate variability (HRV) analysis. Fifty-four consecutive patients with mitral stenosis and sinus rhythm who underwent percutaneous mitral commissurotomy were enrolled. Apart from significant haemodynamic improvements, mean heart rate (HR), LF day, LF night, LF/HF day and night significantly decreased and SDNN, RMSSD, PNN50, HF day and night significantly increased in the early period after PMBC and these changes were preserved for up to one month. SDNN was positively correlated with left ventricle ejection fraction (LVEF) but negatively correlated with mean valve area (MVA), left atrial (LA) diameter and pressure, right atrial (RA) pressure; LF/HF day ratio was positively correlated with LA diameter and pressure, mean transmitral gradient and negatively correlated with LVEF; LF/HF night ratio was positively correlated with LA pressure and mean transmitral gradient. The increase in SDNN was correlated with the change in LA and RA pressure. The decrease in LF/HF ratio after PMBC was significantly correlated with the changes in the mean transmitral gradient, LA pressure and RA pressure. As a result, the heart rate variability and autonomic nervous system function in patients with mitral stenosis are correlated with the atrial pressures and left ventricular function. These parameters significantly change in the early period after PMBC and are preserved at one month. The improvement in the heart rate variability and sympatho-vagal balance are significantly affected by the early changes in atrial pressures after PMBC.

Feasibility, safety, and morphologic predictors of outcome of repeat percutaneous balloon mitral commissurotomy

Early and mid-term results of repeat percutaneous balloon mitral commissurotomy (PBMC) were analyzed in 35 patients with symptomatic valvular restenosis: 12 patients (34%) after first successful PBMC and 23 patients (66%) after successful surgical closed mitral commissurotomy. Twenty-one patients had bilateral fused commissures, and 14 patients had unilateral or bilateral split commissures. Mitral valve area gain was significantly greater in the group with fused commissures compared with the group with split commissures (0.6 +/- 0.2 vs 0.3 +/- 0.2 cm(2), respectively, p = 0.04).

Role of Closed Mitral Commissurotomy for Mitral Stenosis: Mid- and Long-term Surgical Outcome of 36 Patients

To evaluate long-term survival and valve-related complications as well as prognostic factors for mid- and long-term outcome after closed mitral commissurotomy, covering a follow-up period of 14 years. Between 1989 and 2003, 36 patients (28 women and 8 men, mean age 28.8 +/- 6.1 years) underwent closed mitral commissurotomy at our institution. The majority of patients were in New York Heart Association (NYHA) functional class IIB, III, or IV. Indication for closed mitral commissurotomy was mitral stenosis. Closed mitral commissurotomy was undertaken with a Tubbs dilator in all cases. Median operating time was 2.5 hours +/- 30 minutes. After closed mitral commissurotomy, the mitral valve areas of these patients were increased substantially, from 0.9 to 2.11 cm(2). No further operation after initial closed mitral commissurotomy was required in 86% of the patients (n = 31), and NYHA functional classification was improved in 94% (n = 34). Postoperative complications and operative mortality were not seen. Follow-up revealed restenosis in 8.5% (n = 3) of the patients, minimal mitral regurgitation in 22.2% (n = 8), and grade >or=3 mitral regurgitation in 5.5% (n = 2) patients. No early mortality occurred in closed mitral commissurotomy patients. Reoperation was essential for 5 patients following closed mitral commissurotomy; 2 procedures were open mitral commissurotomies and 3 were mitral valve replacements. No mortality occurred in these patients. The mitral valve area was significantly increased and the mean mitral valve gradient was reduced in patients after closed mitral commissurotomy. Closed mitral commissurotomy is a safe alternative to open mitral commissurotomy and balloon mitral commissurotomy in selected patients.

Consequence of atrial fibrillation and the risk of embolism after percutaneous mitral commissurotomy: The necessity of the maze procedure

Background We sought to investigate the incidence and risk of embolism after percutaneous balloon mitral commissurotomy (PMC) and delineated the necessity of the maze procedure in patients with atrial fibrillation (AF). Methods Clinical records of 326 patients, who underwent PMC between April 1988 and March 2003, and 162 patients, who underwent mitral valve surgery (MVS) combined with the maze procedure (MVS/maze) in the same period, were reviewed. We examined the consequence of cardiac rhythm and the incidence and risk of embolism after PMC. Next our current criteria for indication of the maze procedure, which included duration of AF less than 10 years, voltage of f wave on electrocardiography greater than 0.1 mV, cardiothoracic ratio less than 70%, and left atrial dimension less than 70 mm, were applied to all patients. These criteria were satisfied by 190 patients of PMC (PMC group) and 114 patients of MVS/maze (MVS/maze group) and the early and late results of the two groups were compared. Results Thirty-eight patients suffered from embolic complications after PMC. Of these 33 patients experienced AF before intervention. The actuarial embolism-free rate at 10 years was 81.9% in patients with AF before PMC and 92.9% in patients with sinus rhythm before PMC ( p = 0.01). Univariate predictors of embolism after PMC included previous embolic history ( p = 0.01), AF ( p = 0.01), pressure gradient ( p = 0.01), age ( p = 0.03), and mitral valve area ( p = 0.04). Multivariate analysis identified AF as the independent predictor of embolism in the late follow-up period ( p = 0.03). In a comparative study of the selected patients the actuarial AF-free rates after MVS/maze were 89.9% at 1 year and 85.7% at 5 years and were significantly higher than those of 17.3% at 1 year and 4.2% at 5 years after PMC ( p < 0.0001). The actuarial embolism-free rate in the MVS/maze group was 98.0% at 5 years and was significantly higher than that of 84.8% at 5 years and 82.4% at 10 years in the PMC group ( p = 0.01). Conclusions PMC alone is not sufficient with regard to sinus rhythm recovery and prevention of embolism. Surgical treatment concomitant with the maze procedure may be beneficial for patients with AF.

Evaluation of atrial refractoriness immediately after percutaneous mitral balloon commissurotomy in patients with mitral stenosis and sinus rhythm

Background Chronic atrial stretch and rheumatic inflammatory activity leads to atrial dilatation and conduction slowing, and this increases the susceptibility to atrial fibrillation (AF). The aim of this study was to examine the effects of changes in the chronic atrial stretch on atrial refractoriness in the early period after percutaneous mitral balloon commissurotomy (PMBC) in patients with mitral stenosis and sinus rhythm. Methods Twenty-five patients undergoing PMBC were enrolled in this study. We evaluated the changes in pulmonary arterial pressure (PAP), left atrial (LA) pressure, mean mitral diastolic gradient, and mitral valve area in addition to the changes in atrial effective refractory periods (AERPs), AERP dispersion, and intra-atrial and interatrial conduction times after PMBC. Results There were significant decreases in mean diastolic gradient, PAP, mean LA pressure, and LA size after PMBC. Accompanying these acute hemodynamic changes after PMBC, AERPs in high right atrium (HRA), distal coronary sinus (DCS), and right posterolateral (RPL) were found to be increased ( P <.001), and AERP dispersion, PA HIS (an interval between P wave on the surface electrocardiogram and atrial electrogram at the His bundle site), and HRA-DCS intervals were significantly reduced after PMBC ( P <.001). It was revealed with linear regression and correlation analysis that only the changes in AERP dispersion were correlated with changes in LA pressure. Conclusions Relief of chronic atrial stretch results in an increase in AERPs and decrease in AERP dispersion, suggesting the potential reversibility of the electrophysiological features of chronic atrial dilatation. Our study emphasizes that an acute reduction of chronic atrial stretch in mitral stenosis resulted in favorable effects on atrial electrophysiological characteristics, and our results provide the first detailed insights into the electrophysiological changes after PMBC in patients with sinus rhythm.

Usefulness of percutaneous balloon mitral commissurotomy in preventing the development of atrial fibrillation in patients with mitral stenosis

A prospective cohort of patients with mitral stenosis and no history of atrial arrhythmias showed no decrease in the incidence of atrial fibrillation (AF) after successful versus unsuccessful Inoue balloon percutaneous balloon mitral valve commissurotomy. Advanced age and left atrial dimension best predicted which patients developed AF during follow-up, whereas percutaneous balloon mitral valve commissurotomy procedural success and left atrial pressure reduction did not have an impact on incidence of AF.

C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy

C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy

C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy

Background Markers of systemic inflammation including C-reactive protein (CRP) appear to predict morbidity and mortality in various clinical conditions. The presence of systemic inflammation and its impact on the procedural success of percutaneous balloon mitral valve commissurotomy (PBMC) in patients with rheumatic mitral stenosis has not been previously demonstrated. Methods Measurements of CRP with a high-sensitivity assay were performed at the time of PBMC or during post-procedural follow-up in 119 patients with mitral stenosis of rheumatic morphology. Patients were questioned to exclude confounders of CRP elevation and categorized into undetectable (≤0.10 mg/L) and detectable (>0.10 mg/L) CRP levels. Detectable levels were further classified into assay range (>0.10 and ≤6.0 mg/L) and elevated (>6.0 mg/L). Results CRP was detectable in 76% of patients and elevated (>6.0 mg/L) in 36% of patients studied. Procedural success occurred in 89% of patients with undetectable CRP, as compared with only 67% in patients with detectable CRP ( P = .028). This effect remained after controlling for age and valve score (previously described predictors of PBMC success). Conclusions Systemic inflammation is common in patients with rheumatic mitral valve stenosis, and the relationship between procedural success and CRP suggests persistent inflammation may affect the results of PBMC.

Left atrial function as a predictor of haemodynamic response in patients with mitral stenosis: a dobutamine stress echocardiographic study

Objective—The mechanisms of the different haemodynamic and clinical responses to dobutamine infusion in mitral stenosis (MS) are not clearly established. The aim of this study was to evaluate the relation between left atrial (LA) function and haemodynamic response in patiens with MS during dobutamine infusion.Methods and results — Forty-two consecutive moderately symptomatic patients (33 women, 9 men; mean age 46±9, range from 26 to 66), NewYork Heart Association (NYHA) class II with MS (mean mitral valve area 1.7±0.1cm2) were evaluated with dobutamine stress echocardiography. Haemodynamic measurements were obtained at rest and during peak dobutamine infusion. LA fractional shortening at rest was used as an index of global LA function. Group I consisting of patients with significantly elevated pulmonary artery pressure (>60 mm Hg) and mean transmitral gradient (>15 mm Hg) at peak dobutamine infusion were defined as haemodynamically serious MS. Group II consisted of the remaining 30 patients whose haemodynamic data were below these levels.While baseline haemodynamic parameters and mitral valve characteristics were not different between the two groups, LA fractional shortening was significantly lower (18.9±2.8 vs. 32.3±5.1%, p<0.0001) and left atrial dimension was significantly larger in group I (49.7±2.3mm vs 43.6±5.3 mm, p<0.0001). Left atrial fractional shortening was negatively correlated with the increase in mean transmitral gradient (r:-0.58, p<0.01). When the patients were divided using a LA fractional shortening level of 25% as the cut-off point, we observed that the patients with low LA fractional shortening had a greater increase in mean transmitral gradient (7.3±3.1 mm Hg vs. 4.6±1.4 mm Hg), p = 0.005) and pulmonary artery pressure (22.4±3.5 mm Hg vs. 16.1±8.5 mm Hg, p = 0.001) compared to the patients with high LA fractional shortening. Based on these haemodynamic results, management was changed in 12 patients (28%): 5 underwent percutaneous mitral balloon commissurotomy and 7 received intensive medical treatment.Conclusions—The present study demonstrates that haemodynamic response during dobutamine stress echocardiography correlates with LA fractional shortening in patients with MS. The evaluation of left atrial function at rest in patients with ambiguous symptoms and mild mitral stenosis may be useful in clinical decision making. Atrial dysfunction at rest may predict the haemodynamic response during stress echo in these patients.

Conversion of rheumatic atrial fibrillation by amiodarone after percutaneous balloon mitral commissurotomy

Amiodarone, used in conjunction with percutaneous balloon mitral commissurotomy, can safely convert rheumatic atrial fibrillation in 38% of patients compared with 0% in those without it. However, whether this treatment exerts long-term benefits on prognosis awaits further investigation.

Life-saving PTMC for critical calcific mitral stenosis in cardiogenic shock with balloon impasse

A 32-year-old male patient, a case of critical calcific mitral stenosis (following closed mitral valvotomy in 1989) was admitted for mitral valve replacement in September 2001. In hospital, he developed cardiogenic shock, pulmonary oedema and oliguria precluding surgery. An emergency percutaneous transatrial balloon mitral commissurotomy as a life-saving procedure in a valve with unfavourable morphology and 'balloon impasse' is discussed.

Comparison of percutaneous transmitral commissurotomy with Inoue balloon technique and metallic commissurotomy: Immediate and short-term follow-up results of a randomized study

Background The Inoue balloon technique for mitral commissurotomy is well established and carried out worldwide. Metallic commissurotomy is reported to be a cheaper and effective alternative to balloon mitral commissurotomy. Methods One hundred patients were randomized into 2 groups to undergo percutaneous transmitral commissurotomy (PTMC) by means of the Inoue balloon technique (IBMC, n = 49) or metallic commissurotomy (PMMC, n = 51). Patients were crossed over to the other technique when the initial technique was a failure. Success of valvotomy, procedure-related complications, and follow-up events of the 2 techniques were compared. Results Basal echocardiographic and hemodynamic data were similar in both groups. Procedural success was similar in both groups: 45 of 49 procedures (91.8%) in the IBMC group, compared with 46 of 51 procedures (90.18%) in the PMMC group (P = 1.0). Crossover was also comparable, with 1 occurring in the IBMC group, compared with 3 in the PMMC group. Complications such as cardiac tamponade and mitral regurgitation (requiring or not requiring mitral valve replacement) were similar in both groups, with 3 complications in the IBMC group, compared with 4 complications in the PMMC group (P =.29). After a follow-up period of approximately 4 months, both groups had similar event rates and comparable hemodynamic parameters (P = not significant). Conclusions Both IBMC and PMMC are successful means of providing relief from severe mitral stenosis with a gain in valve area and reduction in transmitral gradient. Both techniques have similar procedural success, complication rates, and follow-up events. (Am Heart J 2002;144:1074-80.)

Predictors of long-term event-free survival and of freedom from restenosis after percutaneous balloon mitral commissurotomy

Background Most long-term studies after balloon mitral commissurotomy (BMC) were from industrialized countries. Less is known about the long-term results of BMC from developing countries where patients are younger with fewer mitral valve deformities. Methods Between December 1987 and December 1998, we performed BMC in 654 patients whose mean age was 33 ± 13 years. Baseline and postprocedural variables were evaluated to identify predictors of event-free survival (survival without repeat BMC or mitral valve replacement) and of freedom from restenosis defined as a mitral valve area (MVA) ≥1.5 cm2 after BMC and <1.5 cm2 at follow-up. Results The actuarial survival rates were 98%, 98%, and 97% at 5, 7, and 10 years, respectively. The 5-, 7-, and 10-year event-free survival rates were 85%, 81%, and 72%. Multivariate predictors of a higher 10-year event-free survival rate were lower echocardiographic score (79% for a score ≤8, 61% for a score of 9 to 11, 62% for a score ≥12, P < .001) and cardiac sinus rhythm (P = .04) before BMC, lower mean left atrial pressure (P < .001), lower mitral valve gradient (P < .001), and less than or equal to grade 2 mitral regurgitation (P = .036) after BMC. Restenosis occurred in 16% of patients. The restenosis-free rates were 88%, 80%, and 66% at 5, 7, and 10 years, respectively. A higher freedom from restenosis at 10 years was associated with a lower score (77% for a score ≤8, 45% for a score of 9-11 and 50% for a score ≥12, P = .03) and a larger MVA before BMC (P = .03), a larger MVA (P < .001), and a lower mitral valve gradient (P = .04) after BMC. Conclusions BMC produces excellent 10-year results in patients with pliable mitral stenosis and good results in patients with semipliable or calcified mitral stenosis. BMC is the procedure of choice in patients with pliable valves and it is a reasonable treatment option in young patients with unfavorable mitral valve anatomy. (Am Heart J 2001;142:1072-9.)