Mitigation Of Radiation Research Articles

ELSSIE: A compact stereo spectral imager for planetary surface morphology and composition

Here we describe the design, prototyping, testing, and simulations that were conducted to demonstrate the technology for a concept of the next generation landed planetary spectral imager, the Europa Lander Stereo Spectral Imaging Experiment (ELSSIE). The concept was developed originally for a Europa Lander mission, but the design is applicable, with simplifications, to any ocean world of the outer solar system or to non-icy bodies, including Enceladus, the Moon, Mars, or the surface of Ceres. ELSSIE's design consists of two subassemblies. A Sensor melds a high-resolution, 20-filter, 0.4–3.65 μm, adjustable-focus multispectral stereo imager with a 0.8–3.6 μm point spectrometer, sharing a radiation-shielded single Teledyne H2RG 2048 × 2048 pixel focal plane array (FPA). Each camera includes two 6-position filter wheels with 5 filters and a blank position, providing 10 bandpasses for each of the 2 stereo eyes, and uses 700 × 700 pixels of the FPA. The point spectrometer uses a 6 ×350 pixel strip of the FPA. The Sensor provides stereo and imaging/spectroscopic measurements of reflected light from visible to medium wave-infrared (MWIR) wavelengths to characterize surface morphology, search for pyroclastic plumes, search for organics, identify salts and possible biominerals, characterize crystalline vs. amorphous ice and ice grain sizes, and map the distributions of key phases. In addition to addressing important geologic questions, these measurements support selection of a site for in situ sampling and analysis. A Data Processing Unit (DPU) performs mitigation of radiation that penetrates the shielding using sets of same-filter image frames or spectra of a single spot by removing image spatial pixels with radiation hits, and coadding the remainder for the same spatial pixel, improving signal-to-noise ratio (SNR). The DPU also performs onboard calibration of imager and spectrometer data, co-registration of multispectral images, and calculation of spectral index (“summary parameter”) images for efficient use of lander downlink. Co-registered multispectral image sets and spectra are retained onboard and can be downlinked upon query.

Repurposing of FDA approved kinase inhibitor bosutinib for mitigation of radiation induced damage via inhibition of JNK pathway

Radiotherapy is a common modality for cancer treatment. However, it is often associated with normal tissue toxicity in 20–80% of the patients. Radioprotectors can improve the outcome of radiotherapy by selectively protecting normal cells against radiation toxicity. In the present study, compound libraries containing 54 kinase inhibitors and 80 FDA-approved drugs were screened for radioprotection of lymphocytes using high throughput cell analysis. A second-generation FDA-approved kinase inhibitor, bosutinib, was identified as a potential radioprotector for normal cells. The radioprotective efficacy of bosutinib was evinced from a reduction in radiation induced DNA damage, caspase-3 activation, DNA fragmentation and apoptosis. Oral administration of bosutinib protected mice against whole body irradiation (WBI) induced morbidity and mortality. Bosutinib also reduced radiation induced bone-marrow aplasia and hematopoietic damage in mice exposed to 4 Gy and 6 Gy dose of WBI. Mechanistic studies revealed that the radioprotective action of bosutinib involved interaction with cellular thiols and modulation of JNK pathway. The addition of glutathione and N-acetyl cysteine significantly reduced the radioprotective efficacy of bosutinib. Moreover, bosutinib did not protect cancer cells against radiation induced toxicity. On the contrary, bosutinib per se exhibited anticancer activity against human cancer cell lines. The results highlight possible use of bosutinib as a repurposable radioprotective agent for mitigation of radiation toxicity in cancer patients undergoing radiotherapy.

Spirulina as a promising agent in rheumatoid arthritis with no observed hepatic injury

Aim of the workTo examine early mitigation and conservative effects of low-dose gamma radiation (LDR) or spirulina (SPR) algae on inflammation, oxidative stress and liver function in experimentally-induced arthritis in rats, and comparing such effects to conventionally used rheumatoid arthritis (RA) drugs; methotrexate (MTX) and hydroxychloroquine (HCQ) in an attempt to unleash a safer remedy/therapeutic modality for RA management. Materials and methodsMale Wister albino rats were rendered arthritic by sub-plantar injection of 0.1 ml Freund's complete adjuvant (FCA). Adjuvant-induced arthritis (AIA) rats were treated with each of LDR (0.5 Gy at day 0 of arthritis induction), MTX (1 mg/kg/week, intra-peritoneal), HCQ sulphate (15 mg/kg/day, orally), MTX + HCQ, and SPR (1 g/kg/day, orally) for 28 days. ResultsSub-plantar injection of FCA led to marked increase in paw volume accompanied with increased serum level of C-reactive protein (CRP) and oxidative stress markers including malondialdehyde (MDA) and nitric oxide (NO) levels. Exposure to LDR did not induce any significant alteration in the estimated parameters. Treatment with MTX and HCQ alone or combined induced deterioration in liver function (transaminases), insignificantly reduced paw edema, yet failed to attenuate CRP, MDA and NO levels. Instead, treatment with SPR significantly guarded against changes in nearly all measured parameters and kept liver function at normal level. ConclusionThis is a leading work showing the hepato-preservative impact of spirulina as a promising alternative therapy during the course management of RA. It could thus be considered as a potential option in the management armamentarium of RA.

Improvement of the Destructive Interference Method in the Mitigation of PLC Radiation of Imbalanced Impedance Electrical Networks

Communication technology by power line carrier (PLC) marks its return with the advent of energy-mix. Although appreciated by power-grid operators and customers, this technology suffers from the emission of parasitic electromagnetic radiation. Suspected of causing heath problem, the future of this technology is linked to the level of its radiation reduction. This radiation, which is mainly due to the common mode current, can be attenuated by many ways such as the destructive interference method. The destructive interference method is a dynamic mitigation method mainly used on indoor PLC network. The mitigation of PLC radiation by this method gives reduction rates of more than 24 dB on a balanced impedance electrical network. Unfortunately, the effectiveness of this method decreases sharply depending on the level of network instability (impedance imbalance). This work focuses on improving the effectiveness of the destructive interference method on certain points of the network (point of weak mitigation or amplification of radiation) in an unstable environment. This improvement of the method is centered on the adaptation of the mitigation parameters (phase and amplitude) via a sequential mode of action. The positive impact of the improved method, although focused on a specific area, extended throughout the network. For a network with imbalanced impedance, the average rate of mitigation with this new method exceeds 11 dB.

Histopathological Evaluation of Nanocurcumin for Mitigation of Radiation- Induced Small Intestine Injury.

In the current study, we aimed to mitigate radiation-induced small intestinal toxicity using post-irradiation treatment with nano-micelle curcumin. Small intestine is one of the most radiosensitive organs within the body. Wholebody exposure to an acute dose of ionizing radiation may lead to severe injuries to this tissue and may even cause death after some weeks. This study aimed to evaluate histopathological changes in the small intestine following whole-body irradiation and treatment with nanocurcumin. Forty male Nordic Medical Research Institute mice were grouped into control, treatment with 100 mg/kg nano-micelle curcumin, whole-body irradiation with cobalt-60 gamma-rays (dose rate of 60 cGy/min and a single dose of 7 Gy), and treatment with 100 mg/kg nano-micelle curcumin 1 day after whole-body irradiation for 4 weeks. Afterward, all mice were sacrificed for histopathological evaluation of their small intestinal tissues. Irradiation led to severe damage to villi, crypts, glands as well as vessels, leading to bleeding. Administration of nano-micelle curcumin after whole-body irradiation showed a statistically significant improvement in radiation toxicity of the duodenum, jejunum and ileum (including a reduction in infiltration of polymorphonuclear cells, villi length shortening, goblet cells injury, Lieberkühn glands injury and bleeding). Although treatment with nano-micelle curcumin showed increased bleeding in the ileum for non-irradiated mice, its administration after irradiation was able to reduce radiation-induced bleeding in the ileum. Treatment with nano-micelle curcumin may be useful for mitigation of radiationinduced gastrointestinal system toxicity via suppression of inflammatory cells' infiltration and protection against villi and crypt shortening.

Analysis of the urinary metabolic profiles in irradiated rats treated with Activated Protein C (APC), a potential mitigator of radiation toxicity

Purpose The goal of the current study was to identify longitudinal changes in urinary metabolites following IR exposure and to determine potential alleviation of radiation toxicities by administration of recombinant APC formulations. Materials and methods Female adult WAG/RijCmcr rats were irradiated with 13.0 Gy leg-out partial body X-rays; longitudinally collected urine samples were subject to LC-MS based metabolomic profiling. Sub-cohorts of rats were treated with three variants of recombinant APC namely, rat wildtype (WT) APC, rat 3K3A mutant form of APC, and human WT APC as two bolus injections at 24 and 48 hours post IR. Results Radiation induced robust changes in the urinary profiles leading to oxidative stress, severe dyslipidemia, and altered biosynthesis of PUFAs, glycerophospholipids, sphingolipids, and steroids. Alterations were observed in multiple metabolic pathways related to energy metabolism, nucleotide biosynthesis and metabolism that were indicative of disrupted mitochondrial function and DNA damage. On the other hand, sub-cohorts of rats that were treated with rat wildtype-APC showed alleviation of radiation toxicities, in part, at the 90-day time point, while rat 3K3A-APC showed partial alleviation of radiation induced metabolic alterations 14 days after irradiation. Conclusions Taken together, these results show that augmenting the Protein C pathway and activity via administration of recombinant APC may be an effective approach for mitigation of radiation induced normal tissue toxicity.

Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach

Renal cell carcinoma (RCC) is the most fatal tumor in the urinary system. Resistance development and unmet effective responses, request new anticancer agents with better therapeutic index. Ten new imino-thiazolo-quinoxaline derivatives (5a-j) were synthesized and preliminary evaluated for downregulation of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) activity taking sorafenib as a reference drug. Compounds 5d & 5h showed potent inhibition to VEGFR-2 activity at IC50 89.35 nM & 60.64 nM, respectively, then they both were further evaluated in-vitro against urinary bladder cancer cell line T-24 taking sorafenib as a reference drug. Compound 5h displayed nearly anticancer activity to sorafenib against T-24 cell line in all concentrations tested except at concentration 10 µM where it highly suppressed cell viability to 6.71 % compared to 15.15% of sorafenib. Compound 5h was then evaluated for its ameliorative efect against radiation induced renal tissue injury. Assessment of pro-angiogenic (VEGFR-2), pro-fibrotic (transforming growth factor-beta 1 (TGF-β1)) and apoptotic (caspase-3) markers, as well as histopathological examinations were performed on kidney of irradiated mice. Results showed ability of compound 5h to downregulate VEGFR-2 activity and its cytotoxic effect against RCC, in addition to mitigation of radiation induced renal tissue injury. Ethyl imino-thiazoloquinoxaline carboxylate derivative 5h showed a potential cytotoxic activity against RCC and could be considered a promosing alleviative candidate when employed post radiotherapy regimen.Graphical

Potential hazards and mitigation of X-ray radiation generated by laser-induced plasma from research-grade laser systems

A large range of laser-matter applications employ ultrashort pulses and high laser intensity. Such processes can lead to unrequired X-ray generation, which represents a hazardous radiation factor even for common laboratory research-grade laser systems. We present here an analysis of the radiation dose rate and X-ray spectrum emitted during ablation of a rotating copper cylinder with respect to several laser parameters. The results show that focused sub-picosecond pulses with intensity above 1013 W/cm2 can exceed the annual irradiation limit even in one hour, requiring appropriate shielding for the safety of the researchers.

Review: The effect and possible mitigation of UV radiation on baculoviruses as bioinsecticides

Abstract. Anggraini E, Lau WH, Vadamalai G, Kong LL, Mat M. 2022. Review: The effect and possible mitigation of UV radiation on baculoviruses as bioinsecticides. Biodiversitas 23: 3721-3735. Indiscriminate use of pesticides has raised concerns over environmental and human health issues. A more environmentally-friendly biological approach to control insect pests is gaining importance. For decades, bioinsecticides based on viruses have been used to protect crops and forests. The viruses belonging to the Baculoviridae family are known to infect insect pests, and hence can be used as biopesticides. Baculoviruses are mostly specific to the host and are not lethal to the non-target organism. However, their usage is limited for field application due to a slow kill speed and sensitivity towards UV irradiation. This review paper discusses the life cycle of baculoviruses, their mode of infection and transmission as well as the influence of UV radiation on the effectiveness of baculoviral insecticides for field application.

Acoustic superscatterer enables remote mitigation of underwater source radiation

We propose a contactless and non-closed strategy to mitigate the sound radiated from an underwater source. The problem is formulated as the interaction of the source with different cross-sectional shapes (including ideal zero-cross-section sources, circular-cross-section rods, and rectangular-cross-section rods) and the acoustic superscatterer treated as a concentric cylindrical structure. The acoustic superscatterer consisting of an internal core and a coating made of the double-negative acoustic metamaterial with specific constitutive parameters relies on the coating to virtually magnify its internal core, thus yielding intense multiple scattering with the source. According to the transformation media theory and the method of images, the complete landscape has been presented theoretically and numerically of the remote mitigation of underwater source radiation via an acoustic superscatterer. We demonstrate that by appropriately placing the acoustic superscatterer nearby the source, it can achieve the omnidirectional radiation mitigation stemming from the coherent extinction mechanism. A possible scheme for the practical realization of the acoustic superscatterer is also discussed. This work may facilitate the design and application of remotely placed meta-devices for the manipulation of underwater acoustic waves.

Effects and mitigation of pulsed power radiation on optical fiber velocimetry

Optical fiber diagnostics are extensively used in pulsed power experiments, such as the Sandia Z machine. However, radiation produced in a pulsed power environment can significantly affect these measurements. Catastrophic fiber darkening may be mitigated with shielding, but no flexible material can stop all radiation produced by the machine and/or target. Radiation-induced refractive index modulations are particularly challenging for optical interferometry. Several approaches for radiation-tolerant photonic Doppler velocimetry are discussed here.

The Triomathematics, Trithmetic, Trichometry, Triangulus & Ternary Algebra Expressions that Define the Triophysics and Triological Sciences Related to the Triscalar Mitigation of Non-Ionized Radiation via Bioharmonic Biobalancing Healthy Smart Solar Nanob

The narrative in this paper provides a detailed and descriptive mathematical model for operative Healthy Smart Solar Nanobiotechnology ™ © (Osler, 2021) designed to biobalance a non-ionized irradiated environment. The in-depth mathematics mentioned in this paper are the foundational elements for groundbreaking innovative terminologies and new pioneering scientific fields covered in detail to explicitly explain how Healthy Smart Solar Nanobiotechnology ™ © interacts with and works within the environment. These revolutionary fields of study are directly associated with the mitigating mathematical operation of Solar Smart Nanobiotechnology ™ ©. The mathematics defined in the paper also aid in the creation of new, novel, and original areas and arenas of knowledge that are designed to most accurately describe the trichotomous holistic solutions that can be used to create an all around healthy and safe environment for the well-being of all.

Mechanical properties, radiation mitigation and fire resistance of OPC-recycled glass powder composites containing nanoparticles

The main target of this research is the utilization of low- cost nanoparticles as substantive additions for bolstering the physicomechanical, mitigation of gamma radiation, thermal stability and morphological characteristics of OPC-recycled glass powder hardened composites. Nano MgO and MgFe2O4 spinel NPs were synthesized via the sol–gel route. Characterization of MgO (NM) and MgFe2O4 (NMF) spinel NPs was done using XRD, SEM, TEM, and EDX techniques. Compressive strength, water absorption, bulk density, and total porosity results revealed that partial replacement of OPC by different ratios of waste glass powder waste (WGP) affect negatively on the physicomechanical properties of hardened composites. Inclusion of NPs (NM or NMF) 0.5 and 1 mass % boosts the physicomechanical features of different OPC-WGP hardened composites at most curing ages. The activity of synthesized MgO and MgFe2O4 NPs was affirmed via TGA/DTG and XRD techniques which indicated the formation of diverse hydration yields like CSHs, AFt, AFm, CASHs, MH, CAHs, MSH, CFSH, and CFH that enhances the physicomechanical characteristics as well as the γ- rays shielding % of different OPC-WGP hardened nanocomposites. The thermal stability test was performed at elevated temperatures (300, 500 and 700 °C) for 180 min for all hardened prepared composites after curing for 28 days under normal conditions. The results indicated that the composite containing OPC-10WGP-0.5NMF showed the highest thermal stability. These results were confirmed via SEM/EDX images which displayed a compact and closely packed microstructure of rods-like crystals of CSHs, stacked plates of CASHs, ettringite fibers and symmetrical hexagonal sheets of CH.

FEL performance achieved at PAL-XFEL using a three-chicane bunch compression scheme.

PAL-XFEL utilizes a three-chicane bunch compression (3-BC) scheme (the very first of its kind in operation) for free-electron laser (FEL) operation. The addition of a third bunch compressor allows for more effective mitigation of coherent synchrotron radiation during bunch compression and an increased flexibility of system configuration. Start-to-end simulations of the effects of radiofrequency jitter on the electron beam performance show that using the 3-BC scheme leads to better performance compared with the two-chicane bunch compression scheme. Together with the high performance of the linac radiofrequency system, it enables reliable operation of PAL-XFEL with unprecedented stability in terms of arrival timing, pointing and intensity; an arrival timing jitter of better than 15 fs, a transverse position jitter of smaller than 10% of the photon beam size, and an FEL intensity jitter of smaller than 5% are consistently achieved.

Mitigation of the Background Radiation for Free-Space Optical IM/DD Systems

Atmospheric turbulence and pointing errors cause fluctuations in the signal intensity of the free-space optical intensity-modulation/direct-detection link. Additionally, background radiation brings a noisy photocurrent component into the received signal. Using the generalized likelihood ratio test principle, a Viterbi-type trellis-search sequence receiver is proposed, which estimates both the channel gain and the background component and detects the data sequence simultaneously. It has the advantage of a low search complexity that does not depend on the observation window length $L$ , and its error performance approaches that of detection with perfect channel state information and no background radiation, as $L$ becomes large.

Mitigation of whole-body gamma radiation–induced damages by Clerodendron infortunatum in mammalian organisms

Several phytoceuticals and extracts of medicinal plants are reported to mitigate deleterious effects of ionizing radiation. The potential of hydro-alcoholic extract of Clerodendron infortunatum (CIE) for providing protection to mice exposed to gamma radiation was investigated. Oral administration of CIE bestowed a survival advantage to mice exposed to lethal doses of gamma radiation. Radiation-induced depletion of the total blood count and bone marrow cellularity were prevented by treatment with CIE. Damage to the cellular DNA (as was evident from the comet assay and the micronucleus index) was also found to be decreased upon CIE administration. Radiation-induced damages to intestinal crypt cells was also reduced by CIE. Studies on gene expression in intestinal cells revealed that there was a marked increase in the Bax/Bcl-2 ratio in mice exposed to whole-body 4 Gy gamma radiation, and that administration of CIE resulted in significant lowering of this ratio, suggestive of reduction of radiation-induced apoptosis. Also, in the intestinal tissue of irradiated animals, following CIE treatment, levels of expression of the DNA repair gene Atm were found to be elevated, and there was reduction in the expression of the inflammatory Cox-2 gene. Thus, our results suggest a beneficial use of Clerodendron infortunatum for mitigating radiation toxicity.

Mitigation of numerical Cerenkov radiation and instability using a hybrid finite difference-FFT Maxwell solver and a local charge conserving current deposit

A hybrid Maxwell solver for fully relativistic and electromagnetic (EM) particle-in-cell (PIC) codes is described. In this solver, the EM fields are solved in k space by performing an FFT in one direction, while using finite difference operators in the other direction(s). This solver eliminates the numerical Cerenkov radiation for particles moving in the preferred direction. Moreover, the numerical Cerenkov instability (NCI) induced by the relativistically drifting plasma and beam can be eliminated using this hybrid solver by applying strategies that are similar to those recently developed for pure FFT solvers. A current correction is applied for the charge conserving current deposit to ensure that Gauss’s Law is satisfied. A theoretical analysis of the dispersion properties in vacuum and in a drifting plasma for the hybrid solver is presented, and compared with PIC simulations with good agreement obtained. This hybrid solver is applied to both 2D and 3D Cartesian and quasi-3D (in which the fields and current are decomposed into azimuthal harmonics) geometries. Illustrative results for laser wakefield accelerator simulation in a Lorentz boosted frame using the hybrid solver in the 2D Cartesian geometry are presented, and compared against results from 2D UPIC-EMMA simulation which uses a pure spectral Maxwell solver, and from OSIRIS 2D lab frame simulation using the standard Yee solver. Very good agreement is obtained which demonstrates the feasibility of using the hybrid solver for high fidelity simulation of relativistically drifting plasma with no evidence of the numerical Cerenkov instability.

Comparing the effects of urban heat island mitigation strategies for Toronto, Canada

Increasing awareness of the urban heat island (UHI) effect has raised attention about the outdoor thermal comfort in cities worldwide. Several studies in the last decades have revealed how critical the UHI effect can be in a cold climate, such as in Canadian cities. As a result, in Toronto, one of the cities experiencing the highest rate of building development in developed countries, UHI mitigation strategies are currently the object of extensive debates. This study evaluates different UHI mitigation strategies in different urban neighbors of Toronto, selected according to their building density. The effects of cool surfaces (on the roofs, on the street pavements or as vegetation areas) are evaluated through numerical simulations using the software ENVI-met. Having obtained the surface temperature, outdoor air temperature, mean radiant temperature, and physiologically equivalent temperature, this study compares the possible mitigation of net surface radiation and thermal radiative power. The results demonstrate that the duration of direct sun and the mean radiant temperature, which are strongly influenced by the urban form, play a significant role in urban thermal comfort. Finally, this research supports new policies for promoting sustainable urban development in Toronto, and suggests design strategies for a more resilient urban planning.

The Urban Heat Island Effect in the City of Toronto

The increasing awareness of theurban heat island (UHI) effect has raised the attention for monitoring and evaluating the outdoor thermal comfort in cities worldwide. The urban microclimate is an important factor for pedestrians’ health, but it also affects the urban air quality, the energy use of buildings, citizen wellbeing, and urban sustainability. Issues related to the urban microclimate are becoming more acute in cities given the increasing rates of urban development and construction. In this paper, UHI mitigation strategies in the city of Toronto are assessed. This paper also compares different urban forms according to their orientations, height of wall enclosure, and use of vegetation. The effects of cool surfaces (on the roofs, on the street pavements, or by additional vegetation) are evaluated through numerical simulations using the software ENVI-met. After having obtained the surface temperature, outdoor air temperature, and mean radiant temperature, this study compares three urban areas according to the possible mitigation of net surface radiation and thermal radiative power. The results demonstrate that the duration of direct sun and the mean radiant temperature, which are strongly influenced by the urban form especially in denserareas of the city, play a significant role over the urban thermal comfort. This research supports a sustainable urban developmentin a cold climate, such as that of Toronto. The final scope of this paper isto suggest design strategies for a more resilient urban planning.

Mitigation of Radiation Induced Pulmonary Injury With Systemic Delivery of Mesenchymal Stem Cells

Mitigation of Radiation Induced Pulmonary Injury With Systemic Delivery of Mesenchymal Stem Cells