A lightweight and auto-separated canister cover is required for quick launching in some specific missile launchers. In this paper, a new frangible composite canister cover with the function of specified direction separation is proposed and studied via both experimental and numerical approaches. The frangible canister cover with local non-split weak zone structure, which is manufactured by traditional hand lay-up process with vacuum assisted resin infusion (VARI) method, is designed to fail and separate in a predetermined and specified direction in comparison with the cover with full split weak zone structure. This design is innovative and also necessary for reduction of potential risk to peripheral equipment around the missile launcher. The failure pressure of the cover is determined on the basis of the failure criteria used in finite element (FE) model. In experimental pressurized testing, a number of frangible canister covers subjected to pressure loadings in six cases are studied. Close agreements between the experimental and numerical results have been examined. The frangible canister covers with local non-split weak zone structure which have been studied can be separated and fly out to the specified direction.