Mismatch Negativity Amplitude Research Articles

Reduced Sensitivity to Non-Fear-Related Stimulus Changes in Panic Disorder

Panic disorder (PD) is associated with increased body vigilance and reduced cognitive resources directed at non-fear-related stimuli, particularly in the absence of stimulus-rich environments. To date, only few studies have investigated whether this deficit in PD is reflected in reduced mismatch negativity (MMN), an event-related potential indexing preattentive sensitivity to unexpected stimulus changes. We tested 35 patients affected by PD and 42 matched healthy controls in an oddball paradigm, using frequency and duration deviant stimuli to measure auditory MMN. PD patients displayed reduced duration MMN amplitudes in comparison to healthy controls. No group differences were detected for duration MMN latency, as well as frequency MMN indices. Results support the notion of reduced processing of non-fear-related stimuli in PD patients, particularly with regard to the preattentive processing of sound duration deviants. Additionally, our findings are in line with clinical studies reporting divergent deficits in preattentive processing of frequency and duration deviants.

Elucidating the glutamatergic processes underlying mismatch negativity deficits in early stage bipolar disorder and schizophrenia: A combined 1H-MRS and EEG study

Impairments in mismatch negativity (MMN) in schizophrenia are well-established; these findings have been extended to show impairments at early illness stages and in bipolar disorder. A substantial literature supports MMN as an index of NMDA receptor output, however, few studies have conducted in vivo assessments to elucidate the neurochemical underpinnings of MMN. Sixty young (16–33 years) participants with bipolar disorder (n = 47) or schizophrenia (n = 13) underwent 1H-MRS and MMN assessment. Glutamate over creatine (Glu/Cr) levels in the anterior cingulate cortex (ACC) and hippocampus were determined and MMN was measured frontally and temporally. Correlational analyses assessed the relationship between MMN amplitudes and Glu/Cr. Any significant relationships were assessed for specificity with a follow up correlation analysis of MMN and n-acetyleaspartate (NAA/Cr). No associations between frontal or temporal MMN and ACC or hippocampal Glu/Cr were noted in the bipolar group. In the schizophrenia group, frontal and right temporal MMN amplitudes corresponded with increased ACC Glu/Cr at the trend-level. Right temporal MMN was similarly significantly associated with NAA/Cr. MMN was not associated with hippocampal Glu/Cr. This work provides in vivo evidence that glutamatergic processes may underlie MMN generation in early stage schizophrenia but not in early stage bipolar disorder suggesting differences in the MMN mechanism in these groups. The negative association between ACC Glu/Cr and MMN is consistent with findings of reduced MMN and increased in vivo glutamatergic neurometabolite levels in early stage schizophrenia. Furthermore, these results indicate that examining in vivo NAA/Cr may have provide additional insights into the MMN mechanism in schizophrenia.

Non-speech and speech pitch perception among Cantonese-speaking children with autism spectrum disorder: An ERP study

The present study compared how Cantonese-speaking children with Autism Spectrum Disorder (ASD) and their typically developing counterparts perceived speech pitch and non-speech pitch information using ERP measurements. Sixteen children with ASD (mean age = 10.42 years, SD = 2.12 years) and sixteen normal controls (mean age = 9.48 years, SD =.86 years) participated in two experiments, in which Cantonese lexical tone contrasts and non-speech pitch variations were presented to children following an oddball paradigm when they watched a silent movie. The results showed that: 1) When processing speech pitch contour, the two groups did not differ in the amplitude of mismatch response (p-MMR), while typically developing controls showed larger mismatch negativity (MMN) responses than children with ASD. In the processing of speech pitch height, more positive p-MMR was observed among children with ASD than among normal controls and stronger MMN was found for typically developing children than for children with ASD. 2) For the processing of non-speech pitch, MMN rather than p-MMR was observed and the two groups did not differ significantly with each other in the amplitudes of MMN. These results indicated that Cantonese-speaking children with ASD manifested impaired ability when processing speech pitch information (i.e., lexical tone), which was in line with previous research. However, they did not show the advantage in processing non-speech or auditory pitch information, which was not in agreement with the previous studies. Results were discussed from the perspective of how language background (i.e., Cantonese) might shape the perceptive abilities of children.

Effects of clonidine on MMN and P3a amplitude in schizophrenia patients on stable medication

Schizophrenia is a complex brain disease involving several neurotransmitter systems, including aberrant noradrenergic activity, which might underlie cognitive deficits. Clonidine is an α2A-agonist and previous research has demonstrated that single dosages of clonidine normalize sensori(motor) gating in schizophrenia. Currently, we investigated whether clonidine is able to normalize mismatch negativity (MMN) and P3a amplitude deficits in this same group of patients. This is important, since reports have shown that MMN amplitude is associated with cognitive functioning and daily life functions in schizophrenia. Twenty chronically ill, male schizophrenia patients were tested with the MMN paradigm from the Copenhagen Psychophysiological Test Battery (CPTB) on 5 occasions, separated by a week. Patients received randomized, yet balanced, either a placebo or a single dose (25, 50, 75 or 150 μg) of clonidine (each dose only once) on top of their usual medication on each occasion. Patients were matched on age and gender with 20 healthy controls (HC) who did not receive any treatment. We found decreased MMN and P3a amplitudes in our patients compared to HC. Although clonidine did neither significantly increase MMN nor P3a amplitude in our patients, it did increase certain levels of MMN and P3a amplitude such that these were not significantly different anymore from the healthy controls. Together with our previous reports indicating normalized sensori(motor) gating in the same patients following administration of clonidine, our results could be of potential high clinical relevance in treating schizophrenia. Future studies should focus on longer trial periods to investigate if clonidine also improves cognitive functioning in schizophrenia.

Do theta oscillations explain the somatosensory change detection mechanism?

Recent research has indicated that the mismatch negativity (MMN) is elicited in response to a discernible small change of a somatosensory stimulus applied on the hand. However, the neural mechanism for detecting small change of somatosensory stimulus remains unknown. In the present study, we developed a novel pressure stimulation device using air jet applied on the index finger pad, and determined the just noticeable differences (JNDs) of pressure discrimination for each subject. Using the deviant-standard-reversed oddball paradigm, we analyzed the average dynamic changes in MMN amplitude and changes of evoked spectral power. We found a clear MMN component at the frontal and central regions at 100–300 msec after deviant stimulus presentation. Statistical tests showed that theta band activity played pivotal roles in the generation of the MMN elicited by a change in somatosensory pressure stimulation. Our results indicate that the somatosensory discriminatory process reflected on MMN is accompanied by phase-locked oscillation at the theta frequency.

Effects of maternal B12 supplementation on neurophysiological outcomes in children: a study protocol for an extended follow-up from a placebo randomised control trial in Bangalore, India

IntroductionVitamin B12 deficiency is highly prevalent in pregnant Indian women. Neuropsychological tests have shown an association between low maternal vitamin B12 status and poorer cognitive performances in the offspring, although...

Relationships between cognitive event-related brain potential measures in patients at clinical high risk for psychosis

Neurophysiological measures of cognitive functioning that are abnormal in patients with schizophrenia are promising candidate biomarkers for predicting development of psychosis in individuals at clinical high risk (CHR). We examined the relationships among event-related brain potential (ERP) measures of early sensory, pre-attentional, and attention-dependent cognition, in antipsychotic-naïve help-seeking CHR patients (n = 36) and healthy control participants (n = 22). These measures included the gamma auditory steady-state response (ASSR; early sensory); mismatch negativity (MMN) and P3a (pre-attentional); and N400 semantic priming effects - a measure of using meaningful context to predict related items - over a shorter and a longer time interval (attention-dependent). Compared to controls, CHR patients had significantly smaller P3a amplitudes (d = 0.62, p = 0.03) and N400 priming effects over the long interval (d = 0.64, p = 0.02). In CHR patients, gamma ASSR evoked power and phase-locking factor were correlated (r = 0.41, p = 0.03). Reductions in mismatch negativity (MMN) and P3a amplitudes were also correlated (r = −0.36, p = 0.04). Moreover, lower gamma ASSR evoked power correlated with smaller MMN amplitudes (r = −0.45, p = 0.02). MMN amplitude reduction was also associated with reduced N400 semantic priming over the shorter but not the longer interval (r = 0.52, p < 0.002). This pattern of results suggests that, in a subset of CHR patients, impairment in pre-attentional measures of early information processing may contribute to deficits in attention-dependent cognition involving rapid, more automatic processing, but may be independent from pathological processes affecting more controlled or strategic processing. Thus, combining neurophysiological indices of cognitive deficits in different domains offers promise for improving their predictive power as prognostic biomarkers of clinical outcome.

Weighting of neural prediction error by rhythmic complexity: A predictive coding account using mismatch negativity.

The human brain's ability to extract and encode temporal regularities and to predict the timing of upcoming events is critical for music and speech perception. This work addresses how these mechanisms deal with different levels of temporal complexity, here the number of distinct durations in rhythmic patterns. We use electroencephalography (EEG) to relate the mismatch negativity (MMN), a proxy of neural prediction error, to a measure of information content of rhythmic sequences, the Shannon entropy. Within each of three conditions, participants listened to repeatedly presented standard rhythms of fivetones (four inter-onset intervals) and of a given level of entropy: zero (isochronous), medium entropy (two distinct interval durations), or high entropy (four distinct interval durations). Occasionally, the fourth tone was moved forward in time that is it occurred 100 ms (small deviation) or 300 ms early (large deviation). According to the predictive coding framework, high-entropy stimuli are more difficult to model for the brain, resulting in less confident predictions and yielding smaller prediction errors for deviant sounds. Our results support this hypothesis, showing a gradual decrease in MMN amplitude as a function of entropy, but only for small timing deviants. For large timing deviants, in contrast, a modulation of activity in the opposite direction was observed for the earlier N1 component, known to also be sensitive to sudden changes in directed attention. Our results suggest the existence of a fine-grained neural mechanism that weights neural prediction error to the complexity of rhythms and that mostly manifests in the absence of directed attention.

Акустические стволовые и когнитивные вызванные потенциалы при хроническом нарушении мозгового кровообращения

Current research aimed to investigate informational content of auditory evoked potentials (EP) (acoustic brainstem and cognitive – mismatch negativity) in assessment of brain functional status and cognitive functions in patients with chronic cerebrovascular disease (chronic CVD). Clinical and neurophysiological examination was performed for 33 patients. Group 1 included 12 patients with chronic CVD in carotid circulation, mean age 61,2 ± 6,3 years old; group 2 included 11 patients with chronic CVD in vertebrobasilar circulation, mean age 62,4 ± 8,0 years old; group 3 (control) - 10 patients without cerebrovascular diseases), mean age 54,6±6,4 years old. For registration of acoustic brainstem EP two series of 1000 stimuli were applied (“click” type, duration 0,1 ms, intensity 65 dB above patient’s hearing level, frequency 10 Hz). Mismatch negativity (MMN) was registered in classic odd-ball paradigm (standard stimulus – a sinusoidal tone with 1000 Hz frequency, deviant – with 900 Hz frequency; interstimulus interval – 500 ms). Results. According to results of MMSE, FAB, test of 10 words repetition and Schulte tables patients with chronic CVD, independently of predominantly affected vascular pool, demonstrated cognitive impairment as compared to control group. In patients with chronic CVD no statistically significant differences of acoustic brainstem EP were revealed, however, MMN amplitude was decreased in comparison with control group. It indicates a shortened lifetime of memory traces and deficit in involuntary attention switching in chronic CVD. Investigation of cognitive EP MMN is informative and can be used in assessment of cognitive impairment.

Stochastic game of data transmission in the presence of buffers of finite capacity

Current research aimed to investigate informational content of brainstem acoustic evoked potentials (BAEPs) and auditory cognitive event-related potential — mismatch negativity (MMN) in assessment of brain functional status and cognitive functions in patients with ischemic stroke. MMN is a component of auditory event-related potential with peak latency at 100–250 ms, which reflects automatic process of difference detection between stimuli and neurodynamic processes in auditory cortex at pre-attentive stage. Clinical and neurophysiological examination, including registration of BAEPs and MMN was performed for 22 patients (12 — with ischemic stroke in carotid circulation, 10 — without cerebrovascular diseases). According to results obtained using scales of MMSE, FAB, test with 10 words repetition and Schulte tables, patients with IS demonstrated cognitive impairment as compared to control group. During BAEPs examination, functional changes in brainstem were observed (increased latency of wave V and elongation of interpeak intervals III-V on both sides and III–V ipsilaterally) in patients with ischemic stroke. Also they demonstrated increased peak latency and decreased amplitude of MMN. It points at a decline in auditory discrimination accuracy, shortened lifetime of memory traces and deficit in involuntary attention switching and also indicates of cognitive impairment.

ERP recording shows subclinical differences in ADHD patients with and without Tuberous Sclerosis

To investigate whether among children and adolescents with attention deficit and hyperactivity disorder (ADHD) those with Tuberous Sclerosis (TS) show specific abnormalities of event-related potentials (ERPs). We recruited 10 ADHD patients: 5 with TS (mean age: 12.6 ± 4.3 years) and 5 without TS (mean age: 11.6 ± 3 years). By using an oddball paradigm, auditory mismatch negativity (MMN) and P3b responses were recorded from Fz and Pz electrodes, respectively. All patients were administered with cognitive, executive functioning, and behavioural questionnaires. No difference was found in cognitive and executive functioning between two groups. The P3b amplitude was significantly higher in TS patients (15.6 ± 9 μV) than in children and adolescents without TS (5.5 ± 2.7 μV) (p = 0.04). The MMN amplitude was higher in TS patients (19 ± 18 μV) than in those without TS (9 ± 6.9 μV), although the difference was not significant (p = 0.3). Our results show that P3 and MMN amplitudes are higher in ADHD patients with TS than in those without TS. This means that among children and adolescents with ADHD involuntary and mostly voluntary attention capabilities are better in those with TS. Since this difference was not found by neuropsychological testing, ERP recording can be useful to unravel subclinical differences between two groups.

Reduced late mismatch negativity and auditory sustained potential to rule-based patterns in schizophrenia.

Complex rule-based auditory processing is abnormal in individuals with long-term schizophrenia (SZ), as demonstrated by reduced mismatch negativity (MMN) to deviants in rule-based patterns and reduced auditory sustained potential (ASP) that appears when grouping tones together. Together, this suggests deficits later in the auditory processing hierarchy in Sz. Here, MMN and ASP were elicited by deviations from a complex zig-zag pitch pattern that cannot be predicted by simple linear rules. Twenty-seven SZ and 26 matched healthy controls (HC) participated. Frequent groups of patterns contained eight tones that zig-zagged in a two-up one-down pitch-based paradigm. There were two deviant patterns: the final tone was either higher in pitch than expected (creating a jump in pitch) or was repeated. Simple MMN to pitch-deviants among repetitive tones was measured for comparison. Sz exhibited a smaller pitch MMN compared to HC as expected. HC produced a late MMN in response to the repeat and jump-deviant and a larger ASP to the standard group of tones, all of which were significantly blunted in SZ. In Sz, the amplitude of the late complex MMN was related to neuropsychological functioning, whereas ASP was not. ASP and late MMN did not significantly correlate in HC or in Sz, suggesting that they are not dependent on one another and may originate within distinct processing streams. Together, this suggests multiple deficits later in the auditory sensory-perceptual hierarchy in Sz, with impairments evident in both segmentation and deviance detection abilities.

Mismatch Negativity in Rat Auditory Cortex Represents the Empirical Salience of Sounds.

Mismatch negativity (MMN) is an N-methyl-D-aspartic acid-mediated component and thus has been widely considered a major candidate biomarker of schizophrenia. However, at present, no direct evidence has linked the MMN response and aberrant salience processing reported in schizophrenia patients, i.e., whether MMN represents empirical salience of the deviant stimulus. To test the eligibility of the MMN response as a biomarker of schizophrenia, we hypothesized and verified that the MMN in the rat auditory cortex encodes empirical salience, which depends on both empirical rarity of sound and association of sound with salient events through classical conditioning. We exposed rats to sound or appetitive or aversive classical conditioning and extinction training of aversive conditioning, then recorded MMN from the auditory cortex. We focused on the frequency-dependent asymmetry of the MMN amplitude; increment frequency changes elicit asymmetrically larger MMN amplitudes than do decremental frequency changes. We found that sound exposure reversed this asymmetry in rats, indicating that MMN encodes the empirical rarity of deviant sounds. The MMN amplitude was larger in the appetitive or aversive classical conditioning groups, and smaller after extinction training following aversive conditioning. These results indicate that the MMN response reflects the empirical salience of sound. The present work first linked MMN with empirical salience processing and expands the possibilities of MMN as a strong clinical biomarker of schizophrenia.

Test-Retest Reliability of Mismatch Negativity (MMN) to Emotional Voices.

A voice from kin species conveys indispensable social and affective signals with uniquely phylogenetic and ontogenetic standpoints. However, the neural underpinning of emotional voices, beyond low-level acoustic features, activates a processing chain that proceeds from the auditory pathway to the brain structures implicated in cognition and emotion. By using a passive auditory oddball paradigm, which employs emotional voices, this study investigates the test–retest reliability of emotional mismatch negativity (MMN), indicating that the deviants of positively (happily)- and negatively (angrily)-spoken syllables, as compared to neutral standards, can trigger MMN as a response to an automatic discrimination of emotional salience. The neurophysiological estimates of MMN to positive and negative deviants appear to be highly reproducible, irrespective of the subject’s attentional disposition: whether the subjects are set to a condition that involves watching a silent movie or do a working memory task. Specifically, negativity bias is evinced as threatening, relative to positive vocalizations, consistently inducing larger MMN amplitudes, regardless of the day and the time of a day. The present findings provide evidence to support the fact that emotional MMN offers a stable platform to detect subtle changes in current emotional shifts.

Diminished brain responses to second-language words are linked with native-language literacy skills in dyslexia

Dyslexia is characterized by poor reading skills, yet often also difficulties in second-language learning. The differences between native- and second-language speech processing and the establishment of new brain representations for spoken second language in dyslexia are not, however, well understood. We used recordings of the mismatch negativity component of event-related potential to determine possible differences between the activation of long-term memory representations for spoken native- and second-language word forms in Finnish-speaking 9–11-year-old children with or without dyslexia, studying English as their second language in school. In addition, we sought to investigate whether the bottleneck of dyslexic readers' second-language learning lies at the level of word representations or smaller units and whether the amplitude of mismatch negativity is correlated with native-language literacy and related skills. We found that the activation of brain representations for familiar second-language words, but not for second-language speech sounds or native-language words, was weaker in children with dyslexia than in typical readers. Source localization revealed that dyslexia was associated with weak activation of the right temporal cortex, which has been previously linked with word-form learning. Importantly, the amplitude of the mismatch negativity for familiar second-language words correlated with native-language literacy and rapid naming scores, suggesting a close link between second-language processing and these skills.

Mismatch Negativity in Children: Reference Values.

Introduction The Mismatch Negativity (MMN) auditory evoked potential evaluation is a promising procedure to assess objectively the ability of auditory discrimination. Objective To characterize the latency and amplitude values of MMN in children with normal auditory thresholds and without auditory complaints. Methods Children between 5 and 11 years old participated in the present study. All participants underwent acoustic immittance measurements and tonal and vocal audiometry. The MMN was recorded with the MASBE ATC Plus system (Contronic, Pelotas, RS, Brazil). The electrodes were fixed in Fz (active electrode), Fpz (ground electrode) and in M2 and M1 (references electrodes). The intensity used was 80 dBHL, the frequent stimulus was 1,000 Hz and the rare stimulus was 2,000 Hz. The stimuli were presented in both ears separately. Results For the female group, the mean latencies and amplitude of MMN were 177.3 ms and 5.01 μV in the right ear (RE) and 182.4 ms and 5.39 μV in the left ear (LE). In the male group, the mean latencies were 194.4 ms in the RE and 183.6 ms in the LE, with an amplitude of 5.11 μV in the RE and 5.83 μV in the LE. There was no statistically significant difference between ears ( p = 0.867 - latency and p = 0.178 - amplitude), age ( p > 0.20) and the gender of the participants ( p > 0.05). Conclusion Using the described protocol, the mean latency value of MMN was 184.0 ms for RE and 182.9 ms for LE, and the amplitude was 5.05 μV and 5.56 μV for the left and right ears, respective.

Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study

Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory. In experiment 1, MMNs elicited by standard and deviant auditory stimuli at short and long inter-stimulus intervals (ISIs) were compared between trigeminal neuralgia (TN) patients and demographically matched healthy controls (HCs). The TN patients were found to have stronger attenuation of the MMN at longer ISIs than HCs. Correlation analysis revealed a significant positive correlation between the sensory subscale of McGill Pain Questionnaire and MMN amplitude reduction across ISI conditions. In experiment 2, MMNs recorded before, during, and after the cold pressor test were compared in healthy subjects. MMN amplitude was significantly reduced during pain exposure and recovered immediately thereafter. These results suggest that both chronic pain and acute pain can interfere with automatic change detection processes in the brain. This study provides the first evidence that chronic pain patients have a faster auditory memory trace decay than HCs.

The Relationship between Mismatch Negativity and the COMTVal108/158Met Genotype in Schizophrenia

Mismatch negativity (MMN) is a component of auditory event-related potentials that reflects automatic change detection in the brain, showing qualities of endophenotypes in schizophrenia. MMN deficiency is one of the robust findings in patients, and it reflects both cognitive and functional decline. Catechol-o-methyltransferase (COMT) is a key enzyme involved in regulating dopamine transmission within the prefrontal cortex. A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia. Both the COMTVal108/158Met genotype and MMN are related to cognitive function, but no studies have reported on the relationship between MMN and the COMTVal108/158Met genotype in schizophrenia. This study therefore examined the relationship between COMTVal108/158Met genotype and MMN. The duration of MMN was measured, and the COMTVal108/158Met polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 49 Japanese schizophrenia patients (Val/Val, n = 21; Met carriers, n = 28). Amplitude and latency of MMN were compared between Val/Val and Met carriers.

Electrophysiological evidence for abnormal glutamate-GABA association following psychosis onset

Previous studies have shown glutamatergic dysfunction and γ-aminobutyric acid (GABA)-ergic dysfunction in schizophrenia. Animal studies suggest that N-methyl-d-aspartate receptor (NMDAR) dysfunction and GABA-ergic dysfunction interact with each other and lead to alterations in excitatory/inhibitory balance. The NMDAR and GABAergic-interneuron functions may be indexed by mismatch negativity (MMN) and auditory steady-state gamma-band response (ASSR), respectively. However, no previous studies have tested the hypothesis of an abnormal association between MMN and gamma-band ASSR in the same patients to identify the in vivo evidence of NMDAR-GABA association during the early stages of psychosis. Participants were individuals with recent-onset schizophrenia (ROSZ; N = 21), ultra-high risk (UHR; N = 27), and healthy controls (HCs; N = 24). The MMN amplitude was significantly impaired in ROSZ (p = 0.001, d = 1.20) and UHR (p = 0.003, d = 1.01) compared with HCs. The intertrial phase coherence (ITC) index of gamma-band ASSR was significantly reduced in ROSZ compared with HCs (p < 0.001, d = –1.27) and UHR (p = 0.032, d = –0.75). The event-related spectral perturbation (ERSP) index of gamma-band ASSR was significantly smaller in ROSZ compared with HCs (p < 0.001, d = −1.21). The MMN amplitude was significantly correlated with the ITC in ROSZ (r = −0.69, p < 0.001). These findings provide the first in vivo evidence that an abnormal association of the electrophysiological indices of NMDAR and GABA dysfunctions may be present in recent-onset schizophrenia.

Alterations in electrophysiological indices of perceptual processing and discrimination are associated with co-occurring emotional and behavioural problems in adolescents with autism spectrum disorder

BackgroundMany young people with autism spectrum disorder (ASD) experience emotional and behavioural problems. However, the causes of these co-occurring difficulties are not well understood. Perceptual processing atypicalities are also often reported in individuals with ASD, but how these relate to co-occurring emotional and behavioural problems remains unclear, and few studies have used objective measurement of perceptual processing.MethodsEvent-related potentials (ERPs) were recorded in response to both standard and deviant stimuli (which varied in pitch) in an auditory oddball paradigm in adolescents (mean age of 13.56 years, SD = 1.12, range = 11.40–15.70) with ASD (n = 43) with a wide range of IQ (mean IQ of 84.14, SD = 24.24, range 27–129). Response to deviant as compared to standard stimuli (as indexed by the mismatch negativity (MMN)) and response to repeated presentations of standard stimuli (habituation) were measured. Multivariate regression tested the association between neural indices of perceptual processing and co-occurring emotional and behavioural problems.ResultsGreater sensitivity to changes in pitch in incoming auditory information (discrimination), as indexed by increased MMN amplitude, was associated with higher levels of parent-rated behaviour problems. MMN amplitude also showed a trend positive correlation with parent-rated sensory hyper-sensitivity. Conversely, greater habituation at the later N2 component was associated with higher levels of emotional problems. Upon more detailed analyses, this appeared to be driven by a selectively greater ERP response to the first (but not the second or third) standard stimuli that followed deviant stimuli. A similar pattern of association was found with other measures of anxiety. All results remained in covariation analyses controlling for age, sex and IQ, although the association between MMN amplitude and behaviour problems became non-significant when controlling for ASD severity.ConclusionsFindings suggest that alterations in mechanisms of perceptual processing and discrimination may be important for understanding co-occurring emotional and behavioural problems in young people with ASD.