Purpose. The purpose of the research is to determine temporal regularities of the chemical composition including main macro components and mineralization of the drinking groundwater at the Upper Miocene aquifer complex in Dniper River Basin (Kherson region).Methodology. Geoinformational and statistical approach were used in this study. The methodological approach was proposed to build digital surface of water salinity field and macro components. The input data for modelling were spatial objects such as borehole.Finding. According to the modeling data the average macro components and salt composition of the groundwater at the Upper Miocene aquifer complex in Dniper River Basin into two time periods were determined.Results. During the study period, the mineralization and average concentrations of macro components of drinking groundwater at the Upper Miocene aquifer complex were increased, except hydrogen ion. Resources of drinking groundwater in study region is being heavily affected by the process of salinisation and metamorphization of its chemical composition.