Introduction: Minimally invasive liver surgery is evolving worldwide and robot-assisted liver surgery may have obvious benefits for patients. Safe and proper implementation of a robot-assisted liver surgery program is of utmost importance. Here, we present the steps of establishing a robot-assisted liver surgery program against the background of the initial experience at our institution in Denmark. Methods: A robot-assisted liver surgery program was started at Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark in June 2019. After formal theoretical training and practical simulation training of surgeons and personnel, the program using the Da Vinci Surgical System® (RALS) was initiated and implemented. As time passed, robot-assisted liver surgical procedures have increased in number and difficulty. As of June 2021, 50 cases have been performed. Results: We will in detail discuss the training program, and implementation of the robot-assisted liver surgery program. We will present safety considerations with regard to proper patient selection and how we gradually increased the complexity of the procedures from minor liver resections to extended hemi-hepatectomies. We will present the results of the first 50 consecutive cases who underwent robotic-assisted liver surgery from June 2019 to June 2021 with no mortality, a very low conversion rate and a low rate of adverse events Conclusion: Safe and successful implementation of a robot-assisted liver surgery program is feasible when applying systematic theoretical and practical training, proper patient selection, and a gradual increase in complexity of the procedures.