Minor Movements Research Articles

IMouse: Augmentative Communication with Patients Having Neuro-Locomotor Disabilities Using Simplified Morse Code

Patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, an incurable disease in which motor neurons are selectively destroyed, gradually lose their mobility as organ dysfunction begins, and eventually, patients find it challenging to make even minor movements and simple communications. To communicate with patients with quadriplegia, researchers have focused on movements of the eye, the only moving organ for patients with ALS, and they have investigated the detection of eyeblinks using brainwaves or cameras or other ways to select letters on a screen via eyeball movements based on eye-tracking cameras. However, brainwave-based techniques, which use the electrical signals of eye movements to determine patient’s intentions, are sensitive to noise, often resulting in the inaccurate identification of intent. Alternatively, a camera-based method that uses letter selection detects the movement of eye feature-points, and this method makes it easy to identify a patient’s intentions using a predefined decision-making process. However, it has long processing time and is prone to inaccuracy due to errors in either the Morse code implementation assigned to all alphabets or the sequential selection methods. Therefore, we have proposed iMouse-sMc, a simplified Morse code-based user interface model using an eye mouse for faster and easier communication with such patients. Furthermore, we improved the detection performance of the eye mouse by applying image contrast techniques to enable communication with patients even at night. To verify the excellent performance of the proposed eye mouse for a user interface, we conducted comparative experiments with existing camera-based communication models based on various words. The results revealed that the time of communication was reduced to 83 s and the intention recognition accuracy was improved by ~28.16%. Additionally, even in low-light environments, where existing models are unable to communicate with the patients due to difficulties with eye detection, the proposed model demonstrated its eye detection capability and proved that it can be used universally for communication with patients during the day and at night.

Erratum: Eyestalk Ablation to Increase Ovarian Maturation in Mud Crabs.

Erratum: Eyestalk Ablation to Increase Ovarian Maturation in Mud Crabs.

The esthetic challenge of a malpositioned peg-shaped lateral incisor and a missing contralateral maxillary tooth: report of a case.

A peg-shaped maxillary lateral incisor is an underdeveloped, small, malformed permanent tooth that erupts following the loss of a primary tooth. The maxillary lateral irregularly shaped incisor may be unilateral, on both sides of the central incisors, or accompanied by a missing lateral tooth on the contralateral side of the arch. Peg-shaped maxillary lateral incisors receive a great deal of attention, play a significant role in the displayed smile, and present a treatment challenge during all stages of a patient's life. Clinicians are called to plan the treatment and the timing from as early as the beginning of growth and development. Careful diagnosis may dictate postponing a treatment to later stages of life, especially if the tooth is malpositioned in the arch. The goal of this clinical report was to present a combined treatment for a case with a palatal malpositioned peg-shaped maxillary lateral incisor and a missing contralateral permanent maxillary lateral incisor, creating an esthetic challenge. Moving the malpositioned peg-shaped lateral tooth to the arch simplified and eased the final prosthetic treatment procedure, increasing the treatment predictability. The presented sequence of therapy further stresses the importance of incorporating minor tooth movement, without referring to a specialist, in the daily practice of a prosthodontic-oriented general clinic, by simple accessible means.

Robust Radar-Based Vital Sensing With Adaptive Sinc Filtering and Random Body Motion Rejections

In this paper, we propose a non-contact vital sign monitoring algorithm based on 60GHz Frequency Modulated Continuous Wave (FMCW) radar. At the heart of the algorithm is a bank of sinc filters covering the heart and respiratory frequencies of an healthy adult. The filter bank is adapted, in successive iterations, to the specific cardio-respiratory frequencies of the monitored subject. The adaptability of the algorithm ensures an accurate estimate of Heart Rate (HR) and Respiratory Rate(RR) for a subject sitting in front of the radar at a distance between 0.3m to 1.1m while being robust to minor body movements and harmonics. The efficiency of the solution is demonstrated on an experimental data set including recordings of 10 subjects, where we obtain an Root Mean Square Error (RMSE) of 6.16 bpm for HR and 2.09 rpm for RR.

Comparative Study of High-Resolution LysB29(Nε-myristoyl) des(B30) Insulin Structures Display Novel Dynamic Causal Interrelations in Monomeric-Dimeric Motions

The treatment of insulin-dependent diabetes mellitus is characterized by artificial supplementation of pancreatic β-cell ability to regulate sugar levels in the blood. Even though various insulin analogs are crucial for reasonable glycemic control, understanding the dynamic mechanism of the insulin analogs may help to improve the best-protracted insulin analog to assist people with type 1 diabetes (T1D) to live comfortably while maintaining tight glycemic control. Here, we present the high-resolution crystal structure of NN304, known as insulin detemir, to 1.7 Å resolution at cryogenic temperature. We computationally further investigated our crystal structure’s monomeric-dimeric conformation and dynamic profile by comparing it with a previously available detemir structure (PDB ID: 1XDA). Our structure (PDB ID: 8HGZ), obtained at elevated pH, provides electrostatically triggered minor movements in the equilibrium between alternate conformational substates compared to the previous structure, suggesting it might induce an intermediate state in the dissociation pathway of the insulin detemir’s hexamer:dihexamer equilibrium. Supplemented with orientational cross-correlation analysis by a Gaussian network model (GNM), this alternate oligomeric conformation offers the distinct cooperative motions originated by loose coupling of distant conformational substates of a protracted insulin analog that has not been previously observed.

Coseismic and post-seismic characteristics of the 2021 Ganaveh earthquake along the Zagros foredeep fault based on InSAR data

SUMMARY The Ganaveh earthquake on 2021 April 18 (Mw 5.8) occurred in the southwest of the Dezful embayment of the Zagros Mountain belt, Iran, as a mainly compressive event. The InSAR coseismic displacement maps reveal a maximum of 17 cm of surface displacement in the satellite line of sight direction. InSAR inversion indicates a low-angle NE-dipping causative fault plane with a maximum slip of 95 cm at ∼6 km depth. It highlights the occurrence of the Ganaveh earthquake within the competent layers of the Zagros sedimentary cover, beneath the Gachsaran formation. A slight sinistral slip component (2.9 cm) is retrieved which is compatible with the USGS focal mechanism. Time-series analysis of SAR images after the main shock until the end of 2021 indicates a maximum of 7 cm of post-seismic surface displacement with a similar strike and pattern as the coseismic phase. This similarity and the distribution of aftershocks suggest an afterslip mechanism for the post-seismic phase. The inversion of post-seismic cumulative displacement evaluates a maximum of 30 cm slip at a depth of ∼5 km along the coseismic causative fault. A regional compressional stress regime (N041°E for the direction of the σ1 stress axis) is constrained by using the focal mechanisms of 39 earthquakes occurring between 1968 and 2021, including the Ganaveh main shock and its five larger aftershocks. Applying this direction of compression on the Ganaveh fault plane also results in a minor sinistral movement, consistent with the geodetic results. The relocated main shock and aftershocks as well as our InSAR coseismic displacement situations on the hanging wall of the Zagros Foredeep fault highlight it as the causative fault of the Ganaveh earthquake. To fit the geometry of the Ganaveh rupture plane with the Zagros Foredeep fault, we modelled a listric fault plane and its slip distribution using the available geological data. The retrieved slip variation on the listric plane is in close agreement with the slip pattern on the modelled planar geometry. The low dip angle of the rupture plane combined with a listric geometry highlights the thin-skin characteristics of the Zagros Foredeep fault as the causative fault of the Ganaveh earthquake. The occurrence of this moderate magnitude earthquake on the Zagros Foredeep fault underlines its role as the western structural boundary for the recurrence of Mb > 5 events in the Dezful embayment.

Review of the causes of the unprecedented collapse of the United Grain Growers elevator in Thunder Bay, Ontario

This is a case history of the unprecedented collapse of a pile-supported grain elevator which collapsed suddenly into the harbour in Thunder Bay, Ontario on September 23rd.,1959 after a service life without incident for over 30 years. Many similar grain elevators had been built and operated successfully in the area beginning in the 1880’s. Studies directed at establishing the possible cause(s) included: geotechnical investigations, interrogation of background on design, construction, operation and performance, and a forensic evaluation of evidence revealed during removal of the debris in preparation for reconstruction. The site soil conditions together with features of the collapse are described. The elevator had experienced only minor lateral movements which was in marked contrast to other pile-supported elevators in similar ground conditions nearby. This evidence was considered of particular significance. The collapse is attributed to several factors: the failure of the batter piles, followed by that of vertical piles; to the repairs of the revetment and the associated filling of voids, probably aggravated by a ship collision 6 days before the collapse.

Digital orthodontic extrusion system for complex crown-root fracture of anterior teeth: A technique report

Patients with traumatic dental injuries commonly present in clinical practice with complex crown-root fractures. Prosthodontic treatment of such patients may be unsuccessful because of the violation of the supracrestal tissue attachment, making their management challenging. Minor tooth movement is an effective solution to extruding the residual root but may require referral to an orthodontist. The purpose of this technique was to present a digital orthodontic system including a 3-dimensional virtual patient technique, a computer-aided design and computer-aided manufacture (CAD-CAM) resin facial veneer-retained pontic, and a zirconia post as an orthodontic appliance for tooth extrusion in the esthetic zone. This veneered pontic may also serve as an interim prothesis. The appliance provides a precise design for the direction and extent of orthodontic extrusion.

Developing Highway Capacity Manual Capacity Adjustment Factors for Connected and Automated Traffic at Two-Way Stop-Controlled Intersections

Connected and automated vehicles (CAVs) hold great promise in enhancing transportation operations and roadway capacity. However, there is still limited guidance in the field of highway capacity analysis to help agencies account for the potential benefits. This paper investigates the impact of CAVs on the capacity of two-way-stop-controlled (TWSC) intersections and quantifies capacity adjustments under different CAV scenarios. An isolated TWSC intersection is considered in this research to analyze the CAV impacts on various intersection movement capacities under different CAV market penetration rates (MPRs) and conflict flow rates (CFRs). To model CAVs, cooperative adaptive cruise control (CACC) is considered because it directly impacts the vehicle’s longitudinal car-following behavior and therefore the capacity. Additionally, enhanced gap-acceptance behavior based on vehicle-to-vehicle (V2V) communication is included because it can benefit minor road movements via advanced notifications. This paper collects data from customized, well-calibrated TWSC simulation models constructed in commercially available software. The results show that with the increase in MPRs, CAVs can substantially enhance the capacity of the stop or yield controlled movements, and the improvement is more significant under low CFR scenarios. CAVs can also reduce the follow-up headway and thus improve the potential capacity based on the existing HCM TWSC capacity estimation method. Finally, based on the data collected from the simulation, a capacity adjustment factor (CAF) table is proposed for HCM implementation.

Nature and extent of shear deformation along the eastern and southern terrane boundaries of the Motloutse Complex, eastern Botswana

The Motloutse Complex at the southwestern margin of the Zimbabwe Craton is an Archean medium-grade allochthonous terrane in eastern Botswana. The high-grade gneisses of the Limpopo Complex lie east of the Motloutse Complex and those of the Mahalapye Complex to the south. A number of shear zones are postulated to delineate the aerial extent of the Motloutse Complex, and separate it from the cratonic domain and high-grade terranes. Except the northern margin, these terrane boundaries are poorly understood. This study aims to characterize the nature and extent of shear deformation along the eastern (Dikalate Shear Zone) and southern (Sunnyside Shear Zone) boundaries of the Motloutse Complex. Representative areas from the eastern (Masikate Hills), and southern (Radisele-Mogome) regions were selected for geologic mapping. In view of the poor exposures outside these areas, aeromagnetic data is used to delineate the regional extent of the shear zones. Shear deformation is prominent along the N–S elongate Masikate Hills made up of tonalite gneiss, amphibolite, anorthosite and ultramafic rocks. A dominant right lateral sense of movement, with minor left lateral movement is inferred for the shear deformation. The extent of the N–S trending Dikalate Shear Zone, and its branches, is delineated in the aeromagnetic imagery.In comparison, the Radisele-Mogome area, exposes two set of rocks – tonalite gneiss, amphibolite, ultramafic rocks (part of the Motloutse Complex) to the NE, and granodiorite, diorite gneiss, leucogranite (part of the Mahalapye Complex) to the SW. This is well exemplified in the aeromagnetic image, with change in magnetic signature between rocks in the NE and SW parts. Shear deformation variably overprints rocks along the contact zone. Mylonitic deformation is prominent in the SW part. As along the eastern terrane boundary, a dominant right lateral sense of shear movement is inferred. The extent of the NW-SE trending Sunnyside Shear Zone and its branch is delineated in the aeromagnetic imagery. The results highlight an example of using a combination of geological and geophysical methods to delineate the nature and extent of shear zones that constitute terrane boundaries.

Comparative Evaluation of Bacterial Colonization Color Stability and Halitosis of Oral Appliances Fabricated Using Cold Cure Acrylics, Heat Cure Acrylics and Thermoforming Sheets: An In Vivo Study.

Removable oral appliances form an integral part of interceptive orthodontic procedures. Bacterial colonization leading to halitosis and poor color stability are the major disadvantages of the same in spite of patient acceptability. The aim of the present study was to evaluate bacterial colonization, color stability, and halitosis from the oral appliances fabricated using cold cure, cold cure under pressure pot, heat cure acrylics, thermoforming sheet, Erkodur and antibacterial thermoforming sheet, Erkodur-bz. A group of 40 children was divided into five groups and the appliances were delivered. Bacterial colonization and halitosis were evaluated before giving the appliance to the patient after 1 and 2 months. Color stability was evaluated before giving the appliance to the patient and then after 2 months. This study was designed as a single-blinded randomized clinical trial. Results have shown that after 1 and 2 months, bacterial colonization was higher from the appliances fabricated with cold cure and was lower for the Erkodur group, which was statistically significant. Color stability was more from the appliances fabricated with Erkodur and was less for cold cure, which was statistically significant. Halitosis after 1 month was more from the appliances fabricated with cold cure and less from Erkodur group, which was statistically significant. After 2 months, halitosis was more from the cold cure group and less from Erkodur group, which was not statistically significant. Thermoforming sheet, Erkodur showed better results than other groups in terms of bacterial colonization, color stability, and halitosis. When removable appliances are indicated for minor orthodontic tooth movement, Erkodur is preferable due to the advantages of easy fabrication and less bacterial colonization. Madhuri L, Puppala R, Kethineni B, et al. Comparative Evaluation of Bacterial Colonization Color Stability and Halitosis of Oral Appliances Fabricated Using Cold Cure Acrylics, Heat Cure Acrylics and Thermoforming Sheets: An In Vivo Study. Int J Clin Pediatr Dent 2022;15(5):499-503.

Behavioural characteristics of fatal piglet crushing events under outdoor conditions

Piglets being crushed by the sow is a major welfare challenge in outdoor pig production. To develop interventions with the highest impact on mitigating crushing, it is necessary to know whether the major behaviour leading up to crushing can be considered mainly sow- or piglet-related or due to inappropriate housing conditions and thus whether the genetics of the sow is a factor of importance. In this observational study, piglets classified as fatally crushed based on necropsy were identified on video recordings. Seventy-two crushing events were observed on video in 32 litters. Forty of the events took place in 17 litters born by DanBred Landrace × Yorkshire hybrid sows while 32 events took place in 15 litters born by Topigs Norsvin TN70 hybrids (TN70). The fatal posture changes were rolling (31%), standing to sternal lying (22%), standing to lateral lying (11%, where half were classified as ‘flopping’), sitting to sternal lying (11%), stepping on a piglet (11%), minor movement (10%), sternal lying to standing (3%) and lateral lying to standing (1%). We hypothesised that a larger proportion of the fatal crushing events could be attributed to either inadequate maternal behaviour (no exploration of piglet location before lying down, ‘flopping’ or not responsive to squeezing a piglet), inappropriate housing (squeezing against inventory), low piglet vitality (weak/damaged before) or an unattractive creep area (piglets clustering near the sow). There were no detectable differences between parity and hybrid on whether the sow explored before or made a posture change after crushing. One-third of the crushed pigs were weak/damaged before and took up a larger proportion of the fatally crushed piglets in DanBred (38%) vs. TN70 (16%) sows. ‘Flopping’ and squeezing against inventory were rare (7% and 1%, respectively). The sow explored before lying down in 42% of the events. Exploring before occurred more often before lying sternal and before stepping on a piglet than for all other fatal sow posture changes (P < 0.01). In 18% of the fatal events, the sow made a new posture change within one minute. Based on the findings, options to reduce crushing are discussed, including genetic selection for maternal behaviour and more robust piglets, housing conditions to slow sow posture changes and/or by attracting piglets away from the danger zone.

Orthodontic pretreatment with aligners for optimizing the result prior to fixed restorations in the esthetic zone.

To show the benefit of a minor orthodontic pretreatment prior to fixed restorations in the esthetic zone in challenging situations. Esthetic rehabilitations in complex situations need careful treatment planning and comprehensive interdisciplinary approach. Minor orthodontic pretreatments may transfer complex situations into straight forward situations. Typical indications are space opening in order to provide space for a restoration with anatomic proportion or corrections of the tooth axis. This article presents three clinical cases that show how decision making can be facilitated by a functional and esthetic wax-up/mock-up workflow and how orthodontic pretreatment can contribute to a more functional, less invasive, and more esthetic outcome of restorative treatments in the esthetic zone. Some complex cases in restorative dentistry can be transformed to straight forward cases with the help of minor orthodontic tooth movements.

Connected Transit Bus Dynamic Priority Weight Modeling and Conflicting Request Resolution Control at the Signalized Intersection

Multiaccess edge computing (MEC) and connected vehicle (CV) technologies have shown great potential and strength for traffic perception and real-time computing, which can be applied to enhance the efficiency of connected transit bus operations under their lower penetration conditions. Moreover, for the transit signal priority system, how to establish a model to measure traffic demand for conflicting priority request resolution and improve system response time has been widely researched for the last few decades. This paper proposes a dynamic priority weight (DPW) model for connected transit buses and a traffic signal control approach to coordinate multidirectional conflicting priority requests at a signalized intersection. The proposed model takes advantage of vehicle location, speed, and signal timing data to build time to change (TTOC) correlation functions to measure priority weights of both single-vehicle and directionality accumulation with consideration of vehicles arriving during the current green phase and conflict phase conditions; then, the aggregated priority weight value of each movement can be calculated in real-time. Once the maximum aggregated priority weight value among all movements is determined, the corresponding phase switch strategy is presented for the conflicting request resolution control problem. Homologous algorithm software for distributed deployment can be subsequently used for swift response. Simulation results show that the proposed DPW model-based traffic signal control method shows significant performance advancement, where the queueing vehicle number decrease exceeds 1 pcu/s and the throughput rate of major movements increases by approximately 2% without sacrificing the performance of minor movements in a large amount. What is more, it shows better delay optimization for social vehicles than the algorithm with delay as the objective while declining bus delay appreciable quantity with 43.4 s in average. Field test results also show that this method has excellent abilities to improve intersectional traffic capacity, for which queueing vehicle number and throughput rate indicators of all phases dramatically improved with 1.92 pcu/s and 6.68% on average, except for a slight degradation of individual minor traffic movements with 0.99 pcu/s and 0.11%.

Pedagogy of Suspensions

This paper takes as its catalyst a series of live art events that took place between London and Manchester in 2019. Thinking in conversation with Erin Manning’s propositions for “minor movements” and the Duchampian “infrathin”, we explore the potential for live art to temporarily suspend the thresholds of perceptibility and permissibility in the public realm. We argue that artful techniques of improvisation carry the potential to suspend capitalistic orderings of time by temporarily confounding the perceived barriers between art and life. Drawing together anarchival traces of improvised movement, sound, image, and thought, the paper is composed of vignettes that sketch the infrathin variations of a “pedagogy of suspensions” as elaborated through live art events in a public park, a moving train, a university gymnasium, and an anechoic sound chamber.

The Hebrew Orient: Palestine in Jewish American Visual Culture, 1901–1938 by Jessica L. Carr

Reviewed by: The Hebrew Orient: Palestine in Jewish American Visual Culture, 1901–1938 by Jessica L. Carr Zohar Segev Jessica L. Carr. The Hebrew Orient: Palestine in Jewish American Visual Culture, 1901–1938. Albany: SUNY Press, 2020. 299 pp. The evolution of the Zionist movement under Herzl's leadership coincided with the mass migration of eastern European Jews to the United States that lasted from 1881 until the de facto closure of the United States borders to Jewish immigrants in 1924. American Zionist leaders worked out a unique interpretation of Zionism centered on the quest to legitimize Jewish life in the United States within the bounds of Zionism. They tried to build a Zionist movement that would provide the political, public, and ideological means for improving and bolstering the status of Jews in American immigrant society. Initially, American Zionism was an underfunded minority movement, but subsequently, most markedly following Supreme Court Justice Louis Brandeis's Zionist activity during World War I and the Balfour Declaration, it became one of the most dominant public forces among American Jews and played a major role in the dramatic events experienced by the Jewish people in the 1930s and 1940s. The founding fathers of American Zionism invested considerable intellectual effort into formulating an ideological amalgam that would reconcile Herzl's philosophy with the American version of Zionism. American Zionism did indeed travel a different path from that of its European counterpart. American Zionists generally did not stress migration to Palestine as a fundamental tenet of their ideology and practice, preferring instead to cultivate Zionism as a central component in the fabric of their lives within American society rather than as a means to promote migration to the Land of Israel. Jessica L. Carr's valuable and absorbing book provides a unique and fascinating contribution toward understanding the course of the development of American Zionism and toward illuminating the complex network of relationships that existed between the Zionist movement and the Jewish Yishuv in Palestine, [End Page 458] and between the State of Israel and the American Jewish community. Orientalism and the way in which it is reflected in a wide variety of pictures and images provides the framework for the book's argument. Carr's book begins with a comprehensive discussion of its theoretical background, focusing mainly on the general concept of Orientalism while highlighting its specifically American manifestations. The use of Orientalism as a central organizing theme defining the collection of pictures presented in the book enables the author to discuss the fundamental questions concerning the place of Zionism among American Jews in general and during the first half of the twentieth century in particular. Each chapter of the book is devoted to a discussion of images connected to an organization, event, or publication, such as The Zionist Organization of America, The National Federation of Temple Sisterhoods, The Jewish Encyclopedia, The Jewish Exhibit and Jewish Day at the 1933 World's Fair, and maternalism in Hadassah's "Propaganda." We learn from the book that Orientalism was harnessed by American Jewish opinion shapers as a means to mitigate the tension between the opposition of American Jews in general and the Reform movement in particular to the establishment of a Jewish state in Palestine, and the Zionist movement, which aimed to do exactly that. The use of oriental rather than national elements was an indispensable tool in this process. Orientalism served to forge an affinity with the Land of Israel while eschewing nationalist imagery. The author correctly notes that Orientalism was also a crucial component of Christian imagery relating to the Land of Israel, and that this facilitated the use of these images in a Jewish context as well. Naturally, after the Balfour Declaration in 1917 and as the crisis of European Jewry deepened until its tragic culmination in the Holocaust, the Zionist and national elements in the pictures presented in the book came more to the fore, testifying to the growing importance of Zionism among American Jews. Throughout the book, Carr emphasizes the fact that Mizrahi Jews and Arab inhabitants of Palestine were excluded from the pictures published in the United States. Insofar as they did appear, they were portrayed as passive bystanders who...

Elucidation of partial activation of cannabinoid receptor type 2 and identification of potential partial agonists: Molecular dynamics simulation and structure-based virtual screening

Cannabinoid receptor type 2 (CB2R) is a member of the class A G protein-coupled receptor (GPCRs) family and a component of the endocannabinoid system that is modulated by the psychoactive chemical from Cannabis sativa, partial agonist Δ9-tetrahydrocannabinol (Δ9-THC). Selective activation of CB2R allows for the treatment of inflammatory and immune-related conditions without the psychotropic effects of CB1R. While CB2R-selective agonists are available, CB2R partial agonists are scarce. Hence, the pharmacological difference between CB2R full agonists and partial agonists remains to be deciphered, prompting the search for novel partial agonists. Here, using an induced-fit docking approach, we built a partial agonist Δ9-THC bound CB2R system from the inactive CB2R structure (PDB ID: 5ZTY) and performed microsecond molecular dynamics (MD) simulations. The simulations reveal an upward shift of the “toggle switch” W6.48(258) and minor outward movement of the transmembrane helix 6 (TM6). Dynamic network model identifies a possible communication path between the ligand and the toggle switch” W6.48(258). Furthermore, to identify potential CB2R partial agonists, we conducted structure-based virtual screening of ZINC15 “Druglike” library containing 17,900742 compounds against 3 conformations derived from MD simulation of CB2R complexed with partial agonist Δ9-THC using Glide virtual screening protocol comprising various filters with increasing accuracy. Nine diverse compounds predicted to have high MM-GBSA binding energy scores and good ADMET properties (including high gastrointestinal absorption and low toxicity) are proposed as potential CB2R partial agonists.

Synthesis and characterization of new solid polymer electrolyte (PEG + CH3COONa) for solid-state sodium batteries

Using the solution-cast approach, new solid polymer electrolyte films containing sodium acetate (CH3COONa) in poly (ethylene glycol) were prepared. These polymer electrolyte systems have been characterized using a variety of experimental approaches, including temperature-dependent conductivity and DSC. The endothermic peak at 59.42°C, which corresponds to the melting temperature of pure PEG, is revealed by DSC measurements. Due to the addition of salt to the polymer, a minor movement in the melting point, Tm, towards lower temperatures has been detected. At 30°C, the 80PEG+20CH3COONa electrolyte system had a maximum conductivity of 7.9 × 10-6 S/cm. When compared to pure PEG, the conductivity enhanced by two orders of magnitude. The magnitude of conductivity increased as the temperature raised.

Troubles neurocognitifs et traitement par CAR-T cells

Anti-CD19 CAR T cell therapy is approved for patients with relapsing B-cell lymphoma with ≥ 2 prior systemic therapies and, in recent years, has transformed the care of patients with relapsed and refractory hematologic malignancies. This impressive efficacy is associated with significant toxicity and sometimes life-threatening toxicities, the most prevalent being a cytokine release syndrome (CRS) and neurotoxicity (NT). In a real-life French cohort ( n = 84), sixty-seven patients (80%) developed CRS (grade 1–2 in 63 patients and grade 3–4 in 4 patients). Thirty-six patients (43%) also developed neurotoxicity: grade 1–2 CTCAEv5.0 in 23 patients (64%), and grade 3–4 in 13 patients (36%). Median day of onset of neurological symptoms was day 7 (range: 0–20). Neurotoxicity was associated with CRS in 100% of cases. The most frequent neurological symptoms were cognitive signs, being severe in 36%, and were equally distributed between language disorders and cognitive disorders without language impairment. We did not find evidence for mid-term cognitive deterioration after CAR-T cells. The pattern of neurotoxicity in patients treated for B-cell lymphoma identified cognitive disorders and, to a minor degree, movement and cerebellar disorders, as the hallmark of neurotoxicity linked to CAR T-cell therapy. Although sometimes severe, neurotoxicity is almost always reversible.

ГЕОПОЛІТИЧНІ НАСТРОЇ ДОНЕЧЧАН В УМОВАХ ЗБРОЙНОГО КОНФЛІКТУ (2014–2021 РР.)

The article analyzes the geopolitical orientations of the citizens of Donetsk, in the conditions of the hybrid aggression of the Russian Federation against Ukraine during 2014–2021. It was found out that the prewar period of pro-Russian sentiments of local residents expressed not in separatist ambitions, but in desire to join Russian political/economic projects. In the conditions of "Russian spring" these moods have not proved fundamental changes, as sociological surveys showed. Most of their participants did not aim to join their region to an aggressor country. Further aggravation of the military-political situation by the Kremlin has led to the separation of the Donetsk region in two territories controlled by the Ukrainian authorities and temporarily occupied. This affected the change in geopolitical sympathies. During 2015–2017, an equable commitment between the European Union and Eurasian Customs Union in the polls, with a significant proportion of neutral status, is observed. They are experiencing minor movements towards the growth of the European course. However, the opposite trend is observed in the future. This is due to socio-political events in Ukraine and the influence of hostile propaganda to the mass consciousness of Donetsk.