Ti(CON) formation in high-purity V-10Cr-xTi alloys evidently depends on the Ti concentration. Precipitates are not observed in V-10Cr-0.1Ti alloy, whereas precipitation occurs in 0.5 wt% and higher Ti levels, providing similar precipitation strengthening. 2 wt% Ti addition retards the grain growth. Furthermore, both yield stress and ultimate tensile stress at room temperature and 973 K are steadily increased with rising Ti concentration, and elongation does not reveal clear dependence on Ti concentration. In comparison, lower Ti addition is more beneficial to high-temperature strength than that of room temperature. Additionally, V-10Cr-0.5Ti, V-10Cr-1Ti, and V-10Cr-2Ti alloys would be alternatives to the high-purity V-4Cr-4Ti alloy from the viewpoint of comparable strength and improved low-activation characteristics.