Ministry Of Science Research Articles

Education and human capital: Socio-philosophical aspect

Education is as a social institution that ensures social stability and integration. Additionally, education plays a role in the socialization of individuals, including their acceptance and execution of social roles and statuses. This article raises issues of the development of education as a social institution and as a factor in the for-mation of human capital. The authors present and analyze key theoretical approaches to defining the role and significance of education in shaping human capital. The concept of “human capital” is examined within the context of contemporary Kazakhstani society. Human capital is viewed as an investment in personal devel-opment and social welfare, encompassing not only material success but also improvements in quality of life. The authors analyze the main trends in the development of higher education in Kazakhstan, provide statistics on government educational grants for higher education, and the allocation of quotas across regions of the country. The state, as a regulator, consciously implements policies to support socially vulnerable populations and improve the lives of youth from densely populated areas of the country. This work was carried out as part of a project funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (Grant No AP14971423 “Sociocultural adaptation of students studying under the “Serpin” program to the university space”)

Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients

Background:Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify the particular types of lipids that are regulated as a consequence of paclitaxel administration and may be associated with the occurrence of post-therapeutic neuropathy.Methods:High-resolution mass spectrometry lipidomics was applied to quantify d=255 different lipid mediators in the blood of n=31 patients drawn before and after paclitaxel therapy for breast cancer treatment. A variety of supervised statistical and machine-learning methods was applied to identify lipids that were regulated during paclitaxel therapy or differed among patients with and without post-therapeutic neuropathy.Results:Twenty-seven lipids were identified that carried relevant information to train machine learning algorithms to identify, in new cases, whether a blood sample was drawn before or after paclitaxel therapy with a median balanced accuracy of up to 90%. One of the top hits, sphinganine-1-phosphate (SA1P), was found to induce calcium transients in sensory neurons via the transient receptor potential vanilloid 1 (TRPV1) channel and sphingosine-1-phosphate receptors.SA1P also showed different blood concentrations between patients with and without neuropathy.Conclusions:Present findings suggest a role for sphinganine-1-phosphate in paclitaxel-induced biological changes associated with neuropathic side effects. The identified SA1P, through its receptors, may provide a potential drug target for co-therapy with paclitaxel to reduce one of its major and therapy-limiting side effects.Funding:This work was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG, Grants SFB1039 A09 and Z01) and by the Fraunhofer Foundation Project: Neuropathic Pain as well as the Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD). This work was also supported by the Leistungszentrum Innovative Therapeutics (TheraNova) funded by the Fraunhofer Society and the Hessian Ministry of Science and Arts. Jörn Lötsch was supported by the Deutsche Forschungsgemeinschaft (DFG LO 612/16-1).

THE ROLE OF SCIENTIFIC AND TECHNICAL DISCOURSE IN THE IMPLEMENTATION OF SCIENTIFIC LANGUAGETRAINING OF ENGINEERS

In this article the content analysis of the concept “scientific and technical discourse” is carried out and various aspects of this concept are systematized. Based on foreign and domestic practices, the main components that characterize scientific and technical discourse as a separate category have been revealed. The key characteristics and properties of scientific and technical discourse are identified, the knowledge and use of which will ensure successful communication in the scientific and technical environment. The specific influence of the identified characteristics on the effectiveness of scientific training has been clarified, since their correct use can significantly increase the quality of language education and training of technical specialists as a whole, improve their professional knowledge and language skills, as well as make them more competitive in the labor market.This scientific work is the result of research obtained in the process of project implementation “Intensification of scientific and professional language training of technical specialists in the context of digital transformation of education” (IRN AP19678460) by the grant funding of Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan.

Machine learning and biological validation identify sphingolipids as potential mediators of paclitaxel-induced neuropathy in cancer patients.

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious therapy-limiting side effect of commonly used anticancer drugs. Previous studies suggest that lipids may play a role in CIPN. Therefore, the present study aimed to identify the particular types of lipids that are regulated as a consequence of paclitaxel administration and may be associated with the occurrence of post-therapeutic neuropathy. High-resolution mass spectrometry lipidomics was applied to quantify d=255 different lipid mediators in the blood of n=31 patients drawn before and after paclitaxel therapy for breast cancer treatment. A variety of supervised statistical and machine-learning methods was applied to identify lipids that were regulated during paclitaxel therapy or differed among patients with and without post-therapeutic neuropathy. Twenty-seven lipids were identified that carried relevant information to train machine learning algorithms to identify, in new cases, whether a blood sample was drawn before or after paclitaxel therapy with a median balanced accuracy of up to 90%. One of the top hits, sphinganine-1-phosphate (SA1P), was found to induce calcium transients in sensory neurons via the transient receptor potential vanilloid 1 (TRPV1) channel and sphingosine-1-phosphate receptors.SA1P also showed different blood concentrations between patients with and without neuropathy. Present findings suggest a role for sphinganine-1-phosphate in paclitaxel-induced biological changes associated with neuropathic side effects. The identified SA1P, through its receptors, may provide a potential drug target for co-therapy with paclitaxel to reduce one of its major and therapy-limiting side effects. This work was supported by the Deutsche Forschungsgemeinschaft (German Research Foundation, DFG, Grants SFB1039 A09 and Z01) and by the Fraunhofer Foundation Project: Neuropathic Pain as well as the Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD). This work was also supported by the Leistungszentrum Innovative Therapeutics (TheraNova) funded by the Fraunhofer Society and the Hessian Ministry of Science and Arts. Jörn Lötsch was supported by the Deutsche Forschungsgemeinschaft (DFG LO 612/16-1).

Exploring the Landscape of Polymerase Chain Reaction in Indian Medical Research: A Scientometric Analysis

Background and Aims: The polymerase chain reaction (PCR) has revolutionised medical research in India by offering a rapid and precise method for amplifying deoxyribonucleic acid (DNA) sequences crucial for various applications in healthcare. It aims to investigate publication growth, leading authors, productive journals, collaborating countries, keywords, institutional affiliations and funding agencies involved in PCR-related research within India. Methodology: A scientometric analysis assessed India’s PCR research performance using 10,509 articles from Scopus (2013-2022). Biblioshiny and VOSviewer aided data analysis, while Microsoft Excel facilitated computations. Results: The finding reveals the continuous growth in PCR publications, with significant contributions from researchers like Aman Sharma from the Post Graduate Institute of Medical Education and Research (Chandigarh) and journals like the Indian Journal of Medical Microbiology. Notable contributors hail from the All India Institute of Medical Sciences (AIIMS), New Delhi. International collaborations, especially with the United States, underscore the global outreach of PCR research in India. Keyword analysis reveals emerging trends and research themes in PCR, reflecting its evolving role in addressing contemporary health challenges. Funding agencies such as the Indian Council of Medical Research and the Ministry of Science and Technology, India (DBT) are crucial in supporting PCR research endeavours. Conclusions: This study provides valuable insights into the dynamics of PCR research in India, highlighting areas for future investigation and collaboration to further advance medical research and healthcare outcomes.

STEM образование подобряване на компетентностите на учениците чрез иновации в урока хранене и здраве в V клас

The article focuses on the importance and advantages of STEM education, emphasizing practical learning, critical thinking, and the application of scientific concepts. In Bulgaria, steps are being taken to implement the STEM approach in schools, including the creation of STEM classrooms funded by the Ministry of Education and Science. The main goal of the article is to show how innovative STEM lessons enhance the quality of education and develop key competencies in students. An experiment conducted in the 5th grade on the topic of “Nutrition and Health” demonstrated increased interest and better understanding among students through interactive methods and practical experiments, confirming the effectiveness of this approach.

Prevalence and associated factors of chronic kidney disease among Truká Indigenous adults in Cabrobó, Brazil: a population-based study

The prevalence of chronic kidney disease (CKD) is increasing worldwide, especially in developing countries, due to factors such as lifestyle changes and the rise of non-communicable diseases. Populations living in socioeconomically disadvantaged areas are subject to a higher burden of CKD. However, the burden of CKD on Brazilian Indigenous people, especially those undergoing an advanced urbanisation process, has not yet been described. This cross-sectional study included 1715 Truká Indigenous adults from Cabrobó, Brazil. CKD was defined according to the Kidney Disease Improving Global Outcomes guidelines classification as a urinary albumin/creatinine ratio ≥30mg/g and/or an estimated glomerular filtration rate <60mL/min/1.73m2. Univariate and multiple logistic regression models were used to evaluate factors associated with CKD. Odds ratio (OR) with a 95% confidence interval (CI) was used to measure association. Out of the 1654 participants analysed (61 excluded due to missing data), the prevalence of CKD was 10% (95% CI, 8.6%-11.5%), with a higher prevalence in women compared to men (12.4% versus 6.9%, p<0.001). The mean age was 40.5 years, with 55.6% being women. In univariate analysis, female sex (OR, 1.9; 95% CI, 1.3-2.7), age ≥60 years (OR, 4.6; 95% CI, 3.2-6.6), cardiovascular disease (OR, 2.1; 95% CI, 1.1-4.1), and dyslipidemia (OR, 1.6; 95% CI, 1.1-2.4) were identified as associated factors with CKD. Multiple logistic regression analysis identified age ≥60 years, female sex, and dyslipidemia as independently associated factors with CKD. The prevalence of CKD among Truká Indigenous adults analysed is high and affects a higher proportion of women. Our study found no association between hypertension, diabetes, obesity, and CKD risk, despite their high prevalence. These findings assist in developing early CKD detection strategies in Brazilian Indigenous communities, supporting disease treatment and prevention. National Council for Scientific and Technological Development (CNPq)-Ministry of Science, Technology, and Innovation of Brazil, and the Maria Emília Foundation.

Refocusing education: understanding higher education institutions’ needs for human resource development in Azerbaijan

ABSTRACT Research on the capacity of universities to produce skilled graduates in developing post-Soviet countries is limited. It was reported that innovative companies in Azerbaijan face challenges in recruiting university graduates with the necessary cognitive and technical abilities. Referring to the perspectives of faculty members, university leaders and representatives of the Ministry of Science and Education, the current study explored the factors that were thought to influence the capacity of universities to develop human resources for the modernizing labour market. The study's results also align with the broader discourse on higher education's role in economic development and offer insights for improving alignment between educational outcomes and labour market needs in developing countries like Azerbaijan. While the management style of educational programmes and the faculty members were recognized as influential aspects of quality provision and assurance for skilled human resource development, university managers expressed a desire for greater support and autonomy from macro-level institutions, such as the Ministry of Science and Education, particularly in curriculum design and fostering more effective university-industry partnerships.

Migrant Children and Integration-Related Challenges in Lithuania: The Opinions of Educators (A Case Study)

The number of migrant children in Lithuania is increasing every year. For many years, the majority of migrants (around 82%) were returning Lithuanians, but since 2022, due to the ongoing war between Ukraine and Russia, a large influx of Ukrainian immigrants has been observed: 7761 children have arrived in Lithuania since the outbreak of the full-scale invasion. This study aims to highlight the integration-related challenges that educators face in the context of the increasing number of migrant children. Qualitative, semi-structured interviews (N = 9) were applied to investigate the issue and outline possible solutions from the point of view of educators. The study was conducted in a school with 875 students, including 31 (3.5%) immigrants. The empirical study revealed that the school implements the integration of migrant children in accordance with the recommendations issued by the Ministry of Education, Science, and Sport. Upon the arrival of a migrant child, the committee assesses the child’s knowledge, interviews the parents, and determines the appropriate class placement and learning methods. An individual education plan is then devised based on the expectations of both the child and their parents. Teachers face challenges related to language barriers and cultural differences. The provision of courses developing intercultural competence, more language lessons, and training for both children and their parents are considered to be the most important conditions for the successful integration of migrant children into the education system.

Looking back at the achievements of functional food science in japan.

Functional food science in Japan actively began approximately 40 years ago in the form of specific research projects funded by Grants-in-Aids for Scientific Research from the Ministry of Education, Science and Culture. Then, a new category of healthy food, i.e. "Food for Specified Health Use" (FOSHU), was established. Toshihiko Osawa organized and held the 1st International Conference on Food Factors in Hamamatsu, Japan, in 1995. As examples of key achievements in basic science, the chemical identification of numerous active principles in foods, elucidation of their metabolism pathways, and mechanistic findings by using "omics" technologies and the discovery of target molecules are remarkable. However, whether FOSHU truly contributes to public health is still unknown. In this mini-review, the author looks back on functional food science in Japan to date and, at the same time, describes the prospects to share a vision of the future in the next 10 years.

On the kinetic temperature of a one-dimensional crystal on the long-time scale

We investigate the dynamics of the kinetic temperature of a finite one-dimensional harmonic chain, the evolution of which is initiated by a thermal shock. We demonstrate that the kinetic temperature returns arbitrarily close to its initial state (the one immediately following the thermal shock) infinitely many times, and we give an estimate for the time elapsed until the recurrence. This assertion is closely related to the Poincare recurrence theorem and we discuss their relation. To estimate the recurrence time we use its averaging along system’s trajectory and provide a rigorous mathematical definition of the mean recurrence time. It turns out that the mean recurrence time exponentially increases with the number of particles in the chain. A connection is established between this problem and the local theorems of large deviations theory.Previous studies have shown that in such a one-dimensional harmonic chain, at times of order N, a thermal echo phenomenon is observed — a sharp increase in the amplitude of kinetic temperature fluctuations. In the present work, we give a rigorous mathematical formulation to this phenomenon and estimate the amplitude of the fluctuations.The research is funded by the Ministry of Science and Higher Education of the Russian Federation within the framework of the Research Center of World-Class Program: Advanced Digital Technologies (agreement №075-15-2020-311 dated 04.20.2022).

Public management of scientists’ potential as a source of economic development: A bibliometric analysis

Particular hopes have always been placed on the potential of scientists because they can act as a driving force for effective government. Understanding the importance of scientists ensured progress and prosperity for leading civilizations. This study aims to identify an evolutionary-chronological, geographical, and contextual scientific landscape of the development and management of the potential of scientists through a comprehensive bibliometric analysis. Initially, 5619 publications in the Scopus database were selected from 1957 to 2023. The evolution of knowledge about the importance of public administration of scientific personnel began in 1957 and reached its peak in 2019. Authors from the USA, Great Britain, and Australia have published more about the significance of managing the potential of scientific personnel, and strong schools of knowledge about scientific personnel are concentrated in the USA, France, Canada, and Australia. The analysis of the research’s conceptual orientation shows that publications in environmental and social sciences dominate this sphere. In addition, the bibliometric analysis results show that public management of scientific personnel will bring benefits such as effective government policy decisions, increased innovation activity, commercialization, and improvement of the population’s social life. The results of this study lay the foundation for future research that should improve the management of scientific personnel’s potential. AcknowledgmentsThis study is supported by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan (AP19579256 “Mechanisms for empowering women in scientific activity in the interests of the development of the innovative economy of Kazakhstan”, 2023–2025).

Стратегическая сессия «Приоритеты развития студенческого спорта в Российской Федерации до 2030 года» (Москва, 19 апреля 2024 года)

The report on the results of the strategic session “Priorities for the development of student sports in the Russian Federation until 2030”, which was held within the framework of the International Exhibition and Forum “Russia” by ITMO University with the support of the Ministry of Education and Science of Russia, is presented.

Some issues of public administration of education and science

Problem setting. The essential globalization changes require new approaches to the management of the educational sphere, which is an integral set of educational structures, relations, activities and consciousness that ensures the reproduction and development of the intellectual potential of society. At the same time, it is necessary to ensure an optimal ratio of newly introduced elements with traditional ones intended for the management of an educational institution. Analysis of recent researches and publications. The article mainly analyzes the provisions of Ukraine’s regulatory legal acts. Among domestic scholars, attention is drawn to the works of: V. E. Khoustova, O. I. Reshetnyak, V. A. Zinchenko, M. V. Kryvanych, I. V. Borisov. Purpose of research is to examine the legal regulation of the system of public administration of education and science at the conceptual level. Article’s main body. The draft Strategy of Innovative Development of Ukraine for 2010-2020 in the context of globalization challenges envisaged the need to reform the management of science and innovation and the need to create a new government body the Ministry of Science and Innovative Development, which would play a coordinating role in the scheme of innovation development management. The newly created ministry would have to formulate state scientific, technological and innovation programs that would be implemented in the interests of all ministries and departments, control and direct budget funds to the scientific, technological and innovation sphere, organize an examination of the effectiveness of scientific teams. Conclusions and prospects for the development. The state has experience in the establishment and functioning of an independent central executive body directly accountable to the Cabinet of Ministers of Ukraine, so the proposal for the functioning of such a specialized body is considered to be worthy of support and is quite possible to implement (using this experience with appropriate adaptation to current global challenges and improvement of certain provisions). In our opinion, the main drawback that contributed to the liquidation of the state committee was the lack of a systematic combination of the powers of the committee and the NAS of Ukraine in the field of science. 2. Specialized bodies for the development of science and innovation in Europe play a crucial role in the development of scientific research, technology and innovation, provide funding and support for scientific and technological projects, contributing to economic growth and social progress, so it is important to adopt this experience to ensure optimization of the management of science and education in Ukraine.

Legal regulation of education in Ukraine. Part 2: The accessibility of education under military emergency

After receiving the results of the first study from the cycle of research on the principle of the supremacy of law in education under military emergency, it turned out to be necessary to conduct the next study on the accessibility of education in Ukraine during the mentioned period. It is also associated with the activities of the Cabinet of Ministers of Ukraine and the Ministry of Education and Science of Ukraine, which in 2024 changed the rules for admission to higher educational institutions and limited access to education for those seeking education who declared their desire to study full-time and on a paid basis in postgraduate studies for obtaining the third (educational and scientific) level of higher education. The Ministry of Education and Science of Ukraine, as has always been the case, defended its discriminatory reforms regarding the availability of education, referring to the introduction of a military emergency in Ukraine and problems in the process of mobilizing students for war. At the same time, access to education was limited both for paid education recipients (at their own expense) and for free education recipients (at the expense of state and local allocations). In turn, taking into account the fact that in Ukraine the system of grant education at the expense of scholarships from universities, philanthropists, and sponsors practically does not operate, this situation became a certain cataclysm in the field of education, which negatively affected both students (who began to go abroad en masse) and higher educational institutions. First of all, it is connected with depriving a number of young scientists of the opportunity to continue their research through postgraduate study, and secondly, with depriving higher educational institutions of income, the absence of which can lead such educational institutions to bankruptcy. As a result, the legality of the actions of the Cabinet of Ministers of Ukraine and the Ministry of Education and Science of Ukraine regarding restricting access to education became acute in Ukrainian society. This article is the second article from the cycle of research. It contains the results of a legal study of education accessibility during the military emergency in Ukraine.

Legal regulation of education in Ukraine. Part 3: equal rights, security and dignity of students and language requirements for admission to an educational institution under the conditions of military emergency

The purpose of this article is to continue the analysis of Ukrainian legislation and international acts that regulate or affect the process of regulating basic human rights and freedoms in Ukraine’s education field. The conduct of this study is due to the activities of the Cabinet of Ministers of Ukraine and the Ministry of Education and Science of Ukraine in 2024, which intervened directly during the admission process of students to higher educational institutions during the 2024 admission campaign. The mentioned aspects especially affected the education seekers who declared their desire to study full-time and on a paid basis in graduate school to obtain the third (educational and scientific) level of higher education. Regarding the above, it became necessary to legally examine the observance of basic human rights and freedoms when conducting the admission process under martial law along with implementing and regulating educational activities. In particular, the article examines the main conditions and guarantees of equality of rights of education seekers when enrolling in educational institutions. Additionally, the study underlines the main legal provisions on the human right to safety and dignity, which shall be observed during the admission campaign and when carrying out educational activities in conditions of military emergency as well as in conditions of economic crisis. At the same time, special attention is focused on the need to establish different admission conditions and study conditions for free education and paid education recipients. In addition, the authors analyze the legislation of Ukraine regarding the possibility of using the factor of knowledge of foreign languages as a condition for admission to institutions of higher education, both in the general context and taking into account the specifics of the education received by the student. Thus, this article is the third article from the cycle of research and contains the results of a legal study of the principle of equal rights in the field of education, the principle of safety and human dignity in education, in particular, during the period of military emergency in Ukraine, as well as the principle of Ukrainian-language education in Ukraine.

Ancient history education through project-based learning

Abstract The effectiveness of teaching strategies and resources that promote meaningful content learning is most pronounced when active methods such as project-based learning (PBL) are used to teach Ancient History (Molina, 2020, 53). Therefore, this study focuses on a comprehensive assessment of the methodological and historical competences acquired by students enrolled in the secondary education teacher training programme at the University of Cordoba (Spain). The research, which is non-experimental and quantitative, uses a Likert-type scale and involves the participation of 201 Masters students who have completed the course ‘Learning and Teaching Social Sciences’. The results of the statistical analysis show a positive evaluation of PBL in terms of historical understanding and its effectiveness in improving historical awareness. It is crucial to emphasise the advantages of active and collaborative learning inherent in PBL. However, it is also imperative to acknowledge the challenges that students face in applying their methodological knowledge to the secondary school setting. The transition from theoretical understanding to practical implementation is a significant hurdle for many students aspiring to a career in education. These findings underline the importance of promoting the seamless integration of innovative pedagogical approaches into teacher training programmes in order to effectively address the specific challenges of teaching antiquity in an educational context. Finally, this research was made possible by the Ministry of Science and Innovation's ‘Prueba de Concepto’ project, funded by the European Union under grant number PDC2022-133123-I00, and also by the CLIOGEN project (GINDO-UB/187) on Ancient History.

Development Planning and Forecasting Fleet of Tractors and Grain Harvesters of the Agro-Industrial Complex of the Republic of Kazakhstan

The methodological provisions on the justification and forecasting by the method of astrological modeling of the needs of the agro-industrial complex of Kazakhstan in agricultural machinery for plant growing on the basis of data of tractors and combine harvesters are given in the work. Prepared within the framework of the grant Project of the State Institution “Science Committee” of the Ministry of Education and Science of the Republic of Kazakhstan on topic No. AP19678876 “Effective system of macroeconomic instruments for state regulation of innovative development of the agro-industrial complex of the Republic of Kazakhstan”

Clinical value of plasma pTau181 to predict Alzheimer's disease pathology in a large real-world cohort of a memory clinic

BackgroundThe identification of patients with an elevated risk of developing Alzheimer’s disease (AD) dementia and eligible for the disease modifying treatments (DMTs) in the earliest stages is one of the greatest challenges in the clinical practice. Plasma biomarkers has the potential to predict these issues, but further research is still needed to translate them to clinical practice. Here we evaluated the clinical applicability of plasma pTau181 as a predictive marker of AD pathology in a large real-world cohort of a memory clinic. MethodsThree independent cohorts (modelling [n=991, 59.7% female], testing [n=642, 56.2% female] and validation [n=441, 55.1% female]) of real-world patients with subjective cognitive decline (SCD), mild cognitive impairment (MCI), AD dementia, and other dementias were included. Paired cerebrospinal fluid (CSF) and plasma samples were used to measure AT(N) CSF biomarkers and plasma pTau181. FindingsCSF and plasma pTau181 showed correlation in all phenotypes except in SCD and other dementias. Age significantly influenced the biomarker’s performance. The general Aβ(+) vs Aβ(-) ROC curve showed an AUC = 0.77 [0.74 to 0.80], whereas the specific ROC curve of MCI due to AD vs non-AD MCI showed an AUC = 0.89 [0.85 to 0.93]. A cut-off value of 1.30 pg/ml of plasma pTau181 exhibited a sensitivity of 93.57% [88.72 to 96.52], specificity of 72.38 % [62.51 to 79.01], VPP of 77.85% [70.61 to 83.54], and 8.30% false negatives in the subjects with MCI of the testing cohort.The HR of cox regression showed that patients with MCI up to this cut-off value exhibited a HR = 1.84 [1.05 to 3.22] higher risk to convert to AD dementia than patients with MCI below the cut-off value. InterpretationPlasma pTau181 has the potential to be used in the memory clinics as a screening biomarker of AD pathology in subjects with MCI, presenting a valuable prognostic utility in predicting the MCI conversion to AD dementia. In the context of a real-world population, a confirmatory test employing gold-standard procedures is still advisable.Funding: this study has been mainly funded by Ace Alzheimer Center Barcelona, Instituto de Salud Carlos III (ISCIII), Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Spanish Ministry of Science and Innovation, Fundación ADEY, Fundación Echevarne and Grífols S.A.

EFFECT OF THE CONCENTRATION OF THE PLANT GROWTH REGULATORS ON IN VITRO SHOOT GROWTH OF BLACKBERRY

Berry fruit species, such as Ribes nigrum, are highly esteemed in numerous countries for their biological and economic value, being regarded as important species of small fruits. Ribes nigrum, indigenous to northern Europe, and northern and central Asia. Conserving species like blackcurrant, as highlighted in the International Scientific reports, is crucial due to their potential health benefits and contributions to maintaining vascular health, especially in postmenopausal populations. The discovery that blackcurrant extract, rich in phytoestrogens, shows promise in preventing elastin degradation and pathological vascular remodeling underscores the importance of preserving this species. In Kazakhstan, the preservation of Ribes nigrum includes various factors, such as ecological significance, local economic value through agriculture, and conservation priorities since blackcurrant plays a significant role in the country's biodiversity and traditional uses. The potential of in vitro propagation for rapid mass production of valuable species is substantial. Our study addresses biodiversity conservation by employing this approach. Specifically, we aimed to investigate the impact of nutrient media and growth regulators on shoot multiplication of Ribes nigrum. Our findings reveal that the optimal concentration of plant growth regulators (PGR) significantly influences both the number and length of shoots. Notably, the highest multiplication rate for Ribes nigrum was achieved on MS with a combination of BAP at 0.5 μ/L and GA 0.5 μ/L. In conclusion, our study elucidates the effects of manipulating PGR concentrations in culture media on Ribes nigrum. We recommend optimizing these concentrations to enhance the growth of Ribes nigrum for potential reintroduction efforts and biodiversity conservation. The research is being conducted as part of program BR21882166, which focuses on the scientific and practical aspects of reproducing, conserving, and utilizing fruit and berry plants from the natural flora of Western, Eastern, Central, and Northern Kazakhstan to ensure food security. This program is financially supported by the Ministry of Science and Higher Education of the Republic of Kazakhstan for the period 2023-2025.