Ministry Of Science Research Articles

Assessing the development of a human-centered economy in Russia: A methodological approach

Aim. To build and sub stantiate the author’s methodology for assessing the development of human-centered economy. In view of the insufficiency of theoretical and empirical research in the field of formation and development of economy for human beings, the demand for this scientific research is actualized in order to better meet human needs.Objectives. To develop a methodology for assessing the development of human-centered economy; to test it on the example of the Russian Federation (RF), including Russian regions.Methodology. The methodological basis of the study was formed by the provisions of the theory of human-centered economy. The methods used include normalization, linear scaling, and “series of information criteria” methods. Visualization of the obtained results was carried out on the basis of spatial modeling software package GeoDA. The information base was the data of the Federal State Statistics Service (Rosstat), the Unified Interdepartmental Information and Statistical System, the Ministry of Labor and Social Protection of the Russian Federation, the Ministry of Culture of the Russian Federation, the Ministry of Science and Higher Education of the Russian Federation, the Ministry of Sports of the Russian Federation, Rospatent for 2018-2022.Results. The methodology for calculating the integral index of human-centered economy development has been developed. It was calculated by integrating 87 specific indices and eight subindices. The process of research revealed that this economic system is at the initial stages of development with isogressive-regressive trajectory, has insignificantly developed constituent components in the form of creative and cognitive spheres.Conclusions. The proposed methodology provides a basis for further scientific research in similar studies, as well as for the formation of targeted measures to support the challenging spheres of human activity and human-centered economy as a whole.

Unfolding wall turbulence

We present the project FLARE (Unfolding wall turbulence), funded by the Spanish Ministry of Science and FEDER. The main objective of this project is to contribute to understanding the dynamics of wall-bounded turbulence, exploring two techniques: Lie-Symmetry and Machine Learning. Further, we have compiled several high-quality databases of different flows using Direct Numerical Simulations of the Navier-Stokes equations with the code LISO to use these techniques. This data is available to the turbulence community.

TREATMENT OF EXPERIMENTAL GENERALIZED PURULENT PERITONITIS WITH SILVER NANOPARTICLES AND LOW-FREQUENCY ULTRASOUND

Summary. Generalized purulent peritonitis (GPP) remains one of the most serious complications in abdominal surgery and, in terms of its severity, occupies a leading place among urgent surgical diseases. Sanitation of the abdominal cavity (AC) is the most important stage in the complex treatment of GPP. Low-frequency ultrasound is one of the safe and promising methods of physical antisepsis with many advantages in the sanitation of purulent foci, and silver nanoparticles (AgNPs) have pronounced bactericidal properties against a wide range of multidrug-resistant microorganisms. This study aims to search for new pathogenetically substantiated methods and approaches to treating GPP that provide adequate sanitation of AC and effectively influence the AC microflora in the postoperative and/or interoperative period. Aim. To investigate the effectiveness of treatment of experimental GPP with the combined use of AgNPs and low-frequency US. Materials and methods. The study was performed on an experimental model of GPP in 60 laboratory rats. All test animals were divided into 3 groups: in the first group, planned sanitation of the AC was carried out with low-frequency ultrasound and saline solution, in the second group - with low-frequency ultrasound and SNP solution, in the third, control group – with a 0.05% aqueous solution of chlorhexidine. The number of necessary sanitation, the timing of laparostomy closure, the abdominal cavity index (ACI), the dynamics of systemic endotoxicosis (clinically), the number of complications, mortality, the volume and nature of effusion into the AC, the presence of necrotic tissue and limited purulent foci, changes of the parental and visceral peritoneum, fibrinous layers and intestinal condition was assessed during the treatment. Results and discussion. During the experiment, a significant decrease in the number of necessary sanitation was noted in the AgNPs/US (3.13±0.64) and US (4.63±0.92) groups compared to the control group (6.38±1.6), as well as the timing of laparostomy closure (5.33±1.51) days, (8.33±2.07) days and (11.33±2.94) days, respectively). The difference in ACI was observed starting from day 5: on day 5 in the AgNPs/US group ACI was 9±2.24 and was significantly different from the US group (15±1.58) and the control group (16±2.92); on the seventh day the HPI was, respectively, (5±1.0) in the AgNPs/US group, 12±2.92 in the US group and 15±1.58 in the control group. The use of low-frequency US made it possible to reduce the number of complications in the US and AgNPs/US groups (2 in the AgNPs/US group, 3 in the US group, 14 in the control group) and the mortality rate (35%, 45%, and 60%, respectively). The use of low-frequency US and AgNPs solution contributed to faster and better cleaning of the AC from the purulent peritoneal exudate and fibrin deposition, a reduction in inflammatory manifestations of the visceral and parietal peritoneum, and more rapid normalization of intestinal function. Conclusions. The combined use of AgNPs and low-frequency US leads to a more rapid elimination of purulent-inflammatory processes in the AC, a decrease in the ACI, a reduction in the number of necessary planned sanitation, and the timing of laparostomy closure. Planned sanitation of the AC using low-frequency US and an antiseptic solution of AgNPs helps to reduce the number of complications, the mortality rate and improves the results of treatment of experimental GPP, which allows us to consider the proposed treatment method as promising. Funding. This study was carried out with grant support from the National Research Foundation of Ukraine (project No. 2023.04/0109) and is part of the research work, funded by the Ministry of Education and Science of Ukraine No. 0124U000540.

Regulatory and legal principles of management of sports schools for children and youth

The activities of sports schools for children and youth play a key role in shaping the physical culture of young people, promoting a healthy lifestyle, and preparing future professional athletes. The successful functioning of these schools relies on appropriate legal frameworks that outline the operational rules, requirements for educational processes, funding, and management of facilities. there is a pressing need to analyze the current legal framework governing the management of sports school for children and youth. Considering the constant changes in the legislation and the growing requirements for the quality of sports institutions, there is a pressing need to analyze the current legal framework governing the management of sports schools for children and youth. The purpose of this article is to analyze the regulatory and legal principles of managing the activities of sports schools for children and youth in Ukraine. The key legislative acts regulating the organizational, financial, and legal aspects of the functioning of sports schools for children and youth have been analyzed, including the Constitution of Ukraine, the Law ‘On Physical Culture and Sports,’ and the orders of the Ministry of Education and Science and the Ministry of Youth and Sports. This resolution provides a comprehensive framework for the operation of sports schools for children and youth as well as defines the forms of ownership, legal foundations of their activities, funding procedures, and requirements for athlete training. Particular attention is given to the state social standard in physical culture and sports, which sets requirements for the quality of services, infrastructure, and athlete training. The mechanisms of management that contribute to increasing the efficiency of sports schools for children and youth are highlighted.

Actual problems of physical education of school- aged children in the conditions of an inclusive environment

The article examines the results of an analysis of statistical data from the Ministry of Education and Science of Ukraine on the state of inclusive education in general secondary education institutions, as well as current issues in the physical education of children with special educational needs (SEN). The study uses official reports from 2020 to 2023, along with data on access to inclusive education for children with SEN in the Lviv and Ternopil regions. It has been established that over the past four years, Ukraine has seen an increasing trend in the number of children with special educational needs involved in the educational process in general secondary education institutions, rising from 0.45% in 2020 to 0.89% in 2023. However, pedagogical approaches for each specific type of developmental disorder among children with SEN, considering their level of support and educational-methodical provision in physical education, have not been developed. Moreover, there is a pressing issue of staffing and the need to train physical education specialists for inclusive education.

Path to sustainable development: The effect of China's innovative industrial clusters pilot policy on prefecture-level cities' green total factor productivity

To enhance industrial production efficiency and promote sustainable social development, the Chinese Ministry of Science and Technology announced the innovative industrial clusters pilot (IICP) policy and named three batches of pilot cities in 2013, 2014, and 2017. Whether this significant industrial policy has promoted green total factor productivity (GTFP) is a meaningful but under investigated question in the literature. This study thus explores the above question using a multiperiod spatial difference-in-differences approach and panel data from 273 prefecture-level cities covering 2007–2021. The super slacks based measure and Dagum Gini coefficient are first utilized to assess city-level GTFP and evaluate its spatiotemporal evolutionary features. The intraregional and interregional differences of GTFP reveal expanding trends, with contribution rates to the overall difference above 30%. Benchmark and robustness tests demonstrate promotional direct and spatial spillover effects of the IICP on GTFP. We also employ several additional tests for deeper exploration, determining that a) the direct effect of IICP gradually increases over time, with an evident a time-lag effect, and the positive spatial spillover effect has fluctuated since the policy was enforced; b) the heterogeneity effects of the IICP on GTFP was detected; c) green scientific and technological innovation is an important mechanism of how IICP implementation affects cities' GTFP; and d) the promotional effect of the IICP on GTFP significantly increases when industrial structure upgrading exceeds certain threshold values. The empirical findings of this study not only provide theoretical and practical recommendations for Chinese policymakers to enhance the IICP's policy effect, but also offer suggestions for other emerging markets to develop similar policies for sustainable social development.

Exploring Barriers to the Implementation of Problem-Based Learning Pedagogy in Ordinary Secondary School Mathematics in Tanzania

Globally, a significant body of literature ratifies Problem-Based Learning (PBL) as a promising pedagogical approach to enhance mathematics performance in schools. Tanzania, among other countries, has adopted and integrated PBL into its educational framework to improve students’ academic performance. Despite these efforts, the failure rate in mathematics has consistently exceeded 75% in Tanzania's Certificate of Secondary School Education Examination over the past decade. Therefore, this study aimed to (i) explore teachers’ perceptions of the barriers facing them in implementing PBL pedagogy in secondary schools and (ii) explore the barriers to implementing PBL pedagogy as perceived by students in secondary schools. This study employed a qualitative research approach and a case study research design in which simple purposive sampling technique was used to select eight (8) mathematics teachers and forty eighty (48) form four students from secondary schools in Arusha city council. Interview and Focus group discussion were used to collect data on the barriers for effective implementation of PBL pedagogy. Findings from thematic analysis revealed that large class sizes, a shortage of mathematics teachers, insufficient instructional time, inadequate teaching and learning materials, and competence insufficient to implement PBL pedagogy were the barriers. The study recommends that the Ministry of Education, Science and Technology improve the teaching and learning environment, providing in-service training to mathematics teachers on PBL pedagogy and employing more mathematics teachers in schools.

7th ERL Conference Links between Beliefs and Language held at the heart of Europe, in Sarajevo, Bosnia and Herzegovina – a report

On 27-28 June 2024, the Association for the Educational Role of Language organized the 7th International Pedagogic and Linguistic Conference entitled Links between Beliefs and Language. The conference was held at International University of Sarajevo (IUS) in Bosnia and Herzegovina, in cooperation with the English Language and Literature program. Around 50 scholars presented 38 topics and discussed links between beliefs and language through sociolinguistic, cultural, literary, semantic, instructional, personal, interpersonal and inter-linguistic lenses. The Conference was a unique event that brought together participants from different countries: Poland, Georgia, Estonia, United Kingdom, the Czech Republic, Italy, Oman, Spain, Bulgaria, Norway, Bosnia and Herzegovina, Serbia, North Macedonia, Slovenia, Romania and Ukraine. The importance of this scientific and academic event was recognized by the local government, with the Ministry of Science, Higher Education and Youth of Sarajevo Canton granting funds and supporting the Conference. The two-day conference was preceded by a pre-conference meeting, during which...

Legal regulation of education in Ukraine. Part 6: Features of admission to higher education in Ukraine

This article examines the legal issues of regulating the access of citizens of Ukraine to higher education of the third educational and scientific degree (doctor of philosophy) in the paradigm of international acts, the Constitution of Ukraine, the Laws of Ukraine, and Resolutions of the Cabinet of Ministers of Ukraine in the field of education. This is related to the existence of certain legal conflicts in the education sector, which arose as a result of the ambiguity and imperfection of the legislation of Ukraine on education, which the Ministry of Education and Science of Ukraine uses to illegally restrict the access of citizens of Ukraine to higher education of the third educational and scientific degree. Taking into account the requirements of the Constitution of Ukraine, the Universal Declaration of Human Rights of the United Nations, and the Convention for the Protection of Human Rights and Fundamental Freedoms, the article presents the results of a study of the peculiarities of the application of the provisions of the relevant legislative acts in the field of education (with all changes and additions introduced as of September 1, 2024), namely the Law of Ukraine “On Education” (dated September 5, 2017, under No. 2145-VIII), the Law of Ukraine “On Higher Education” (dated July 1, 2014, under No. 1556- VII) and the “Procedure for Training Candidates for Higher Education Degrees of Doctor of Philosophy and Doctor of Sciences in institutions of higher education (scientific institutions)”, approved by Resolution No. 261 of the Cabinet of Ministers of Ukraine (dated March 23, 2016). At the same time, the research is mainly focused on the peculiarities of applying the above­mentioned legislative acts to determine the differences in the conditions of access to free and paid education and the established legitimacy and feasibility of certain elements of such conditions. Principally this concerns the introduction by the State of Ukraine of unified professional exams and other tests (with the use of external independent evaluation) as a condition for access to the next stage of tests, namely, entrance exams and other tests for admission to study introduced by higher education institutions of Ukraine. That is, the legality of establishing a two-level system of competitions and entrance tests for those who wish to obtain a higher education of the third educational and scientific degree (doctor of philosophy) on a paid basis (i.e., at their own expense or the expense of non-state grants and scholarships) is being considered. The article is the sixth one within the cycle of studies in which the peculiarities of access of Ukrainian citizens to higher education in martial law conditions are addressed.

Analysis of the impact of mechanisms of integration of university science into the regional innovation system on the spatial development of the Voronezh region

Relevance. University science is the basis for the progressive development of the regions of the Russian Federation, providing new knowledge and ideas, turning knowledge into technology and accelerated development of the cultural environment. The introduction of scientific research into the educational process is necessary and important conditions for maintaining the high professional level of teachers, the formation of professional competencies, and advanced training of future specialists. In the last few years, the main economic processes have demonstrated positive dynamics, which indicates the effectiveness of the implemented strategy of socio-economic development of the region, as well as an effective policy of spatial development of the territory are key factors in achieving a positive trend in the development of the region. Minister of Science and Higher Education V.N. Falkov in April 2024 He stated the need to transform the higher education system, focusing on specialized higher education based on an interdisciplinary approach that will more effectively integrate university science into regional spatial development and the national innovation system.The purpose of the study is to determine the mechanisms of integration of university science in the spatial development of the Voronezh region through the innovation system.Objectives: to analyze the impact of the mechanisms of integration of university science on the trends of spatial development; to analyze scientific and technological development; to formulate the main conclusions about university science as part of the socio-economic system of the territory.Methodology. The general scientific methods of logical analysis, method of desk research, method of systematization, descriptive method were used in the study. Results. The study revealed the key factors that contributed to the positive dynamics of the economy of the Voronezh region and considered the mechanisms of integration of university science into the regional innovation system.Conclusions. In the realities of scientific and technological development there is a need to improve the methods of integration of university science into the regional innovation system, and recommendations related to the optimization of spatial development of the Voronezh region in order to improve the quality and attractiveness of university science on the basis of innovative aspects functioning in the region have been proposed.

Global radiotherapy demands and corresponding radiotherapy-professional workforce requirements in 2022 and predicted to 2050: a population-based study.

Addressing the challenge of cancer control requires a comprehensive, integrated, and global health-system response. We aimed to estimate global radiotherapy demands and requirements for radiotherapy professionals from 2022 to 2050. We conducted a population-based study using data from the Global Cancer Observatory (GLOBOCAN) 2022 and predicted global radiotherapy demands and workforce requirements in 2050. We obtained incidence figures for 29 types of cancer across 183 countries and derived the cancer-specific radiotherapy use rate using the 2013 Collaboration for Cancer Outcomes Research and Evaluation model. We delineated the proportion of people with cancer who require radiotherapy and can be accommodated within the existing installed capacity, assuming an optimal use rate of 50% or 64%, in both 2022 and 2050. A use rate of 50% corresponds to the global average and a use rate of 64% considers potential re-treatment scenarios, as indicated by the 2013 Collaboration for Cancer Outcomes Research and Evaluation (CCORE) radiotherapy use rate model. We established specified requirements for teletherapy units at a ratio of 1:450 patients, for radiation oncologists at a ratio of 1:250 patients, for medical physicists at a ratio of 1:450 patients, and for radiation therapists at a ratio of 1:150 patients in all countries and consistently using these ratios. We collected current country-level data on the radiotherapy-professional workforce from national health reports, oncology societies, or other authorities from 32 countries. In 2022, there were an estimated 20·0 million new cancer diagnoses, with approximately 10·0 million new patients needing radiotherapy at an estimated use rate of 50% and 12·8 million at an estimated use rate of 64%. In 2050, GLOBOCAN 2022 data indicated 33·1 million new cancer diagnoses, with 16·5 million new patients needing radiotherapy at an estimated use rate of 50% and 21·2 million at an estimated use rate of 64%. These findings indicate an absolute increase of 8·4 million individuals requiring radiotherapy from 2022 to 2050 at an estimated use rate of 64%; at an estimated use rate of 50%, the absolute increase would be 6·5 million individuals. Asia was estimated to have the highest radiotherapy demand in 2050 (11 119 478 [52·6%] of 21 161 603 people with cancer), followed by Europe (3 564 316 [16·8%]), North America (2 546 826 [12·0%]), Latin America and the Caribbean (1 837 608 [8·7%]), Africa (1 799 348 [8·5%]), and Oceania (294 026 [1·4%]). We estimated that the global radiotherapy workforce in 2022 needed 51 111 radiation oncologists, 28 395 medical physicists, and 85 184 radiation therapists and 84 646 radiation oncologists, 47 026 medical physicists, and 141 077 radiation therapists in 2050. We estimated that the largest proportion of the radiotherapy workforce in 2050 would be in upper-middle-income countries (101 912 [38·8%] of 262 624 global radiotherapy professionals). Urgent strategies are required to empower the global health-care workforce and facilitate the fundamental human right of access to suitable health care. A collective effort with innovative and cost-contained health-care strategies from all stakeholders is warranted to enhance global accessibility to radiotherapy and address challenges in cancer care. China Medical Board Global Health Leadership Development Program, Shanghai Science and Technology Committee Fund, China Ministry of Science and Technology Department of International Cooperation High Level Cooperation and Exchange Projects, and Fudan University Office of Global Partnerships Key Projects Development Fund. For the Arabic, Chinese, French, Russian and Spanish translations of the summary see Supplementary Materials section.

Sports Development Management in the Republic of Armenia: The Structure and Statistics

Sports is one of the many branches of the national economic complex and represents a complex and unique socio-economic system, the activity of which is characterized by multifaceted social and state relations. It should be considered that the management structure of any socio-economic sector of the state is largely determined first by the state policy, the very structure of the state. It should be organically integrated into the sports movement management system. The state body responsible for the development of sports in Republic of Armenia (RA) is the Ministry of Education, Science, Culture and Sports (MESCS), which is entrusted with the functions of implementing state policy and legal regulation, as well as providing support to sports organizations and sports federations. The main goal of its activity is the formation of a positive attitude of society, the state and the entire nation towards sports as an effective means of maintaining and strengthening human health, an integral part of universal culture, and as a factor, especially in the physical and moral education of children and young people. The Ministry carries out the functions of state policy and legal regulation in physical culture, sports and youth issues and the processes of developing and implementing them. Along with that, public sports organizations in the form of NAOC of Armenia and national sports federations and units play an important role in the development of sports in the republic. Funding for mass sports and high-performance sports is increasing year by year in Armenia, which is aimed at increasing the number of events, as well as increasing the number of incentives for the achievements of people who do sports and high-level athletes.

Международные конференции, посвященные исто­рии чингизидских государств

On August 19, 2024, Astana hosted an international conference on “Topical issues on the history of the Kazakh Khanate from the second half of the 15th – first half of the 18th century”. On August 20–21, another international conference was held, entitled, “Ethnopolitical history of the Jochi, Chagatai, Haidu and Moghulistan uluses” and dedicated to the 800th anniversary of the formation of the Jochid Ulus. The event was organized by the Ministry of Science and Higher Education of the Republic of Kazakhstan, the Scientific Institute for the Study of the Jochid Ulus. More than 70 leading scientists, specialists and researchers researching the history of nomadic societies and empires, including the history of the Kazakh Khanate and the Golden Horde, from Kazakhstan, Russia, Uzbekistan, China, Canada, Japan, and Austria participated in the conferences. The conferences discussed the issues of studying the Kazakh Khanate and the ethnopolitical history of the Jochi, Chagatai, and Haidu Uluses which were formed during the collapse of the Mongolian Empire. Moreover the participants discussed the issues of developing the fourth volume of the History of Kazakhstan and creating a separate book dedicated to the history of the Kazakh Khanate. Within the framework of the 2nd conference dedicated to the history of the Jochi, Chagatai, Haidu uluses, and Moghulistan, a private screening was organized for the documentary film “Batu: Historical Detective” created by Kazakh director Rashid Nugmanov. The was contributed to by historians and researchers from Kazakhstan, Russia, Ukraine, Mongolia, France, Canada and the USA.

A Comprehensive Review of the Integrated Program for Out-of-School Adolescents (IPOSA) in Tanzania

The purpose of this study was to analyze how the Integrated Program for Out-of-School Adolescents (IPOSA) addresses the educational challenges of out-of-school adolescents in Tanzania through its flexible, competency-based approach. The study also sought to provide insights for improving the program’s effectiveness and scalability. A descriptive and analytical design were employed, using existing data from official reports, program documentation and previous studies. The study draws on qualitative and quantitative data to assess the program’s development, structure and outcomes. Key documents analyzed include the 2015/2016 profiling study on out-of-school children, IPOSA administrative and real-time implementation reports, comprehensive reports from UNICEF and Tanzania’s national education strategies. Key study revealed that IPOSA is distinct from previous educational models due to its emphasis on flexibility, inclusivity and competence-based learning. It effectively addresses the diverse needs of out-of-school adolescents, equipping them with practical, real-world skills that align with workforce demands. The program’s design, which integrates literacy, life skills, vocational training and entrepreneurship, has demonstrated a significant impact on marginalized groups. The study recommends that the Ministry of Education, Science, and Technology, along with the Institute of Adult Education, allocate additional resources to expand IPOSA’s reach, particularly in marginalized communities. Additionally, regular curriculum updates, enhanced collaboration between stakeholders and improved monitoring and evaluation systems are recommended to ensure the program’s continued success and scalability.

Mental Health in Education for Crisis-affected Preschool Children: Multilevel Monitoring

Introduction: The crisis in Ukraine, related to military actions, poses a significant threat to the mental health of preschool children due to their vulnerability, limited self-awareness, and perception of their surroundings, as well as the critical developmental phase characterized by the establishment of foundational personality structures. Chronic stress and trauma can disrupt normal brain development, potentially leading to delays in cognitive and emotional development in the long term. Therefore, it is essential to systematically identify and analyze the negative factors affecting the mental development of preschool children across key domains, contributing to educational deficits and developmental gaps, and to design targeted interventions to solve those emerging issues. Purpose: The study is focused on the development and implementation of strategies for supporting, preserving, and enhancing the mental well-being of preschool children residing in areas proximate to armed conflict. The research underscores the importance of early and systematic monitoring across various levels (including children, families, educators, professional associations, and early childhood education institutions, including those with alternative forms of preschool education designed to accommodate crisis conditions). Methodology: Multilevel monitoring has encompassed 3,843 children situated in conditions detrimental to their mental health and development across seven frontline regions of Ukraine (Dnipropetrovsk, Donetsk, Zaporizhzhia, Mykolaiv, Odesa, Sumy, Kharkiv). This initiative is a part of a project by "All-Ukrainian Public Organization 'Association of Early Childhood Education Professionals'", with informational support from the Ministry of Education and Science of Ukraine and is being implemented in collaboration with the United Nations (UNICEF) project "Improving Access to Early Childhood Education Services in Emergencies and Early Recovery in Ukraine." Level 1 - initial, intermediate, and summative monitoring involved establishing the baseline developmental level of senior preschool children and identifying gaps across key areas, with subsequent measurement of progress and its correlation with interventions aimed at supporting and maintaining children’s mental health. Measurement of indicators was expressed through their manifestation at the minimum and maximum points for each child, with the establishment of an average score (average score = sum of all individual scores divided by the number of children). The average score reflects the overall performance between the lowest and highest indicators across children, educators, regions, and nationally. This analysis was conducted using a web-based spreadsheet program, Google Sheets, which is part of the Google Drive office suite." Level 2 - organizational and methodological monitoring focused on evaluating the methodological and organizational aspects of the educational process as fundamental factors in preventing negative impacts on children’s mental health. This was conducted using an electronic form developed in Google Forms, utilizing the Google Sheets web-based spreadsheet program, which is part of the Google Drive office suite. Level 3 - monitoring the quality of the educational process in early childhood education institutions using the ECERS-3 methodology, which allows for the analysis of comfort levels, developmental conditions, safety, and support for the mental health of preschool children. This involves an electronic Google Form equivalent to the paper-based ECERS-3 assessment; automatic calculations are performed according to the formulas specified by the international ECERS-3 methodology (Harms et al., 2020). Results: The study of the development of senior preschool children, based on the analysis of key domains through regular psychological and pedagogical observations and the use of diagnostic tools over a period of five months, enabled the identification of early signs of stress, anxiety, and other emotional manifestations. This assessment facilitated the evaluation of children's mental health and the development of a system of effective interventions to address the identified issues. Conclusion: The study underscores the importance of identifying personal characteristics of senior preschool children and developmental gaps across key domains to organize interventions and support measures aimed at preserving mental health, ensuring comprehensive development, and mitigating negative factors in crisis conditions. The results of the multilevel monitoring are valuable for updating educational practices and adapting them to crisis situations. Addressing the identified educational losses and gaps, including those related to social-emotional development and stress resilience, allows for the development of structured programs to counteract negative impacts and facilitate the recovery of preschool children

Коммуникативные приемы управления цифровой репутацией органов исполнительной власти

The article considers the concept of digital reputation in relation to the executive authorities of the Russian Federation, as well as identifies the technological and communicative methods of its formation and maintenance. The digital reputation of a public administration body is a multicriterial assessment of its activities. It appears in media space and reflects the opinions of socially active population. Digital reputation is not identical to digital image. The authors revealed the following discursive factors that shape stereotypes about public administration. For instance, an indefinitely wide range of addressees lack basic knowledge in public administration; public assessments are flexible and unpredictable; some Internet users practice provocative speech behavior, etc. The research featured internet posts made by the Ministry of Science and Higher Education of the Russian Federation in the social network VKontakte. The service Popsters.ru made it possible to rate them by user involvement. A discursive and stylistic analysis of the posts with a high engagement coefficient revealed the following effective tools for managing the digital reputation of the authorities: hashtags as means of data distribution and systematization, dialogical and personalized presentation, interactive forms of communication (voting, polls, etc.), timely reaction to user comments, etc.

Testing an artificial intelligence algorithm to predict fetal heartbeat of vitrified-warmed blastocysts from a single image: predictive ability in different settings.

Could an artificial intelligence (AI) algorithm predict fetal heartbeat from images of vitrified-warmed embryos? Applying AI to vitrified-warmed blastocysts may help predict which ones will result in implantation failure early enough to thaw another. The application of AI in the field of embryology has already proven effective in assessing the quality of fresh embryos. Therefore, it could also be useful to predict the outcome of frozen embryo transfers, some of which do not recover their pre-vitrification volume, collapse, or degenerate after warming without prior evidence. This retrospective cohort study included 1109 embryos from 792 patients. Of these, 568 were vitrified blastocysts cultured in time-lapse systems in the period between warming and transfer, from February 2022 to July 2023. The other 541 were fresh-transferred blastocysts serving as controls. Four types of time-lapse images were collected: last frame of development of 541 fresh-transferred blastocysts (FTi), last frame of 467 blastocysts to be vitrified (PVi), first frame post-warming of 568 vitrified embryos (PW1i), and last frame post-warming of 568 vitrified embryos (PW2i). After providing the images to the AI algorithm, the returned scores were compared with the conventional morphology and fetal heartbeat outcomes of the transferred embryos (n = 1098). The contribution of the AI score to fetal heartbeat was analyzed by multivariate logistic regression in different patient populations, and the predictive ability of the models was measured by calculating the area under the receiver-operating characteristic curve (ROC-AUC). Fetal heartbeat rate was related to AI score from FTi (P < 0.001), PW1i (P < 0.05), and PW2i (P < 0.001) images. The contribution of AI score to fetal heartbeat was significant in the oocyte donation program for PW2i (odds ratio (OR)=1.13; 95% CI [1.04-1.23]; P < 0.01), and in cycles with autologous oocytes for PW1i (OR = 1.18; 95% CI [1.01-1.38]; P < 0.05) and PW2i (OR = 1.15; 95% CI [1.02-1.30]; P < 0.05), but was not significantly associated with fetal heartbeat in genetically analyzed embryos. AI scores from the four groups of images varied according to morphological category (P < 0.001). The PW2i score differed in collapsed, non-re-expanded, or non-viable embryos compared to normal/viable embryos (P < 0.001). The predictability of the AI score was optimal at a post-warming incubation time of 3.3-4 h (AUC = 0.673). The algorithm was designed to assess fresh embryos prior to vitrification, but not thawed ones, so this study should be considered an external trial. The application of predictive software in the management of frozen embryo transfers may be a useful tool for embryologists, reducing the cancellation rates of cycles in which the blastocyst does not recover from vitrification. Specifically, the algorithm tested in this research could be used to evaluate thawed embryos both in clinics with time-lapse systems and in those with conventional incubators only, as just a single photo is required. This study was supported by the Regional Ministry of Innovation, Universities, Science and Digital Society of the Valencian Community (CIACIF/2021/019) and by Instituto de Salud Carlos III (PI21/00283), and co-funded by European Union (ERDF, 'A way to make Europe'). M.M. received personal fees in the last 5 years as honoraria for lectures from Merck, Vitrolife, MSD, Ferring, AIVF, Theramex, Gedeon Richter, Genea Biomedx, and Life Whisperer. There are no other competing interests. N/A.

Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors.

Viremic non-progressors (VNPs) represent an exceptional and uncommon subset of people with HIV-1, characterized by the remarkable preservation of normal CD4+ Tcell counts despite uncontrolled viral replication-a trait reminiscent of natural hosts of simian immunodeficiency virus. The mechanisms orchestrating evasion from HIV-1 pathogenesis in human VNPs remain elusive, primarily due to the absence of integrative studies. We implemented a novel single-cell and multiomics approach to comprehensively characterize viral, genomic, transcriptomic, and metabolomic factors driving this exceedingly rare disease phenotype in 16 VNPs and 29 HIV+ progressors. Genetic predisposition to the VNP phenotype was evidenced by a higher prevalence of CCR5Δ32 heterozygosity, which was associated with lower levels of CCR5 expression and a lower frequency of infected cells in peripheral circulation. We also observed reduced levels of plasma markers of intestinal disruption and attenuated interferon responses in VNPs. These factors potentially drive the other phenotypic traits of immune preservation in this population, including the unaltered tryptophan metabolic profile, reduced activation of cytotoxic lymphocytes, and reduced bystander CD4+ Tcell apoptosis. In summary, our comprehensive analysis identified intricate factors collectively associated with the unique immunovirological equilibrium in VNPs, shedding light on potential avenues for therapeutic exploration in managing HIV pathogenesis. The work was supported by funding from the Spanish Ministry of Science and Innovation and the National Institutes of Health (NIH).

Perioperative chemotherapy and nivolumab in non-small-cell lung cancer (NADIM): 5-year clinical outcomes from a multicentre, single-arm, phase 2 trial

Perioperative immunotherapy improves short-term outcomes in resectable non-small-cell lung cancer (NSCLC). We now report 5-year survival from the NADIM trial to assess its long-term benefit. NADIM was a multicentre, single-arm, phase 2 trial conducted across 18 hospitals in Spain. Patients were aged 18 years or older, had an Eastern Cooperative Oncology Group performance status of 0 or 1, and had histologically or cytologically confirmed, treatment-naive, resectable stage IIIA NSCLC (American Joint Committee on Cancer, 7th edition criteria). The neoadjuvant treatment consisted of three cycles of intravenous paclitaxel (200 mg/m2) and carboplatin (area under the curve 6 mg/mL per min) with nivolumab (360 mg). After surgery, 1 year of adjuvant treatment with intravenous nivolumab monotherapy was administered (240 mg every 2 weeks for 4 months, followed by 480 mg every 4 weeks for 8 months). The primary endpoint was 24-month progression-free survival, with 5-year progression-free survival and overall survival as secondary endpoints, assessed in the intention-to-treat population (ie, all patients who received neoadjuvant treatment). Toxicity profile was also assessed as a secondary endpoint. This trial is registered at ClinicalTrials.gov (NCT03081689) and is complete; this is the final report of the trial. Between April 26, 2017, and Aug 25, 2018, 51 patients were assessed for eligibility, of whom 46 comprised the intention-to-treat population (34 [74%] male and 12 [26%] female, median age 63 years [IQR 58-70]). Follow-up was concluded at 60 months (data cutoff July 11, 2023; median follow-up 60·0 months [IQR 60·0-60·0]). 5-year progression-free survival in the intention-to-treat population was 65·0% (95% CI 49·4-76·9), and overall survival was 69·3% (53·7-80·6). Disease progression occurred in 11 (24%) patients; 14 (30%) patients died, including nine (20%) from disease relapse and five (11%) from non-tumour-related causes. Treatment-related adverse events (TRAEs) of grade 3 or worse occurred in 14 (30%) of 46 patients during neoadjuvant treatment and in seven (19%) of 37 during adjuvant treatment. The most common grade 3 or worse TRAEs were increased lipase and febrile neutropenia (three [7%] each) during neoadjuvant treatment, and elevated serum lipase (four [7%]) and elevated serum amylase (three [8%]) during adjuvant treatment. Serious TRAEs included elevated serum lipase and neutropenia (one [2%] each) during neoadjuvant treatment, and elevated serum lipase (one [3%]) during adjuvant treatment. No treatment-related surgery delays, deaths, or unexpected long-term toxicities were reported. Perioperative chemoimmunotherapy showed a promising long-term benefit with no concerning safety data, reinforcing its use in resectable stage IIIA NSCLC. Bristol-Myers Squibb, Spanish Ministry of Science, Instituto de Salud Carlos III, European Union.

The effect of Plasmodium falciparum exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in infants and children: an ancillary observational immunological study to a phase 3, randomised clinical trial

The RTS,S/AS01E malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended). We aimed to study the effect of previous Plasmodium falciparum exposure on the antibody responses to RTS,S/AS01E vaccination in infants and children, and the mediating effect of baseline (including maternal) anti-circumsporozoite protein (CSP) antibodies. In this observational study, we included children and infants from six African countries (Burkina Faso, Gabon, Ghana, Kenya, Mozambique, and Tanzania) enrolled in the MAL067 immunology ancillary study of the RTS,S/AS01E phase 3 clinical trial from March 27, 2009, to Jan 21, 2011. We used comparator-vaccinated infants and children to identify antibody-based signatures of previous P falciparum exposure, which were later applied to RTS,S/AS01E-vaccinated infants and children. In these participants, we explored the relationship between vaccine antibody immunoglobulin G (IgG) responses measured by ELISA and pre-vaccination serological markers of malaria exposure by assessing the IgG levels against 1000 P falciparum antigens using partial proteome microarrays. We included 718 comparator-vaccinated infants (348 [48%]) and children (370 [52%]) and 606 RTS,S/AS01E-vaccinated infants (329 [54%]) and children (277 [46%]). Anti-CSP IgG responses to primary vaccination did not correlate with a baseline signature of previous exposure in children, suggesting that prior P falciparum exposure does not significantly affect antibody immunogenicity in children (Pearson's r=-0·02 [95% CI -0·13 to 0·10]). By contrast, high P falciparum exposure signature levels at the time of vaccination in infants, presumably driven by maternally transferred antibodies and declining within the initial 6-12 months of life, correlated with reduced RTS,S/AS01E responses (r=-0·17 [-0·27 to -0·06]). This negative correlation was stronger for anti-CSP IgG than for the exposure signature or any other more immunogenic blood stage P falciparum antigens (r=-0·42 [-0·50 to -0·33]), persisted after adjustment by baseline levels of the exposure signature (semi-partial correlation r=-0·44 [-0·55 to -0·33]), and involved antibodies to the central NANP region (r=-0·39 [-0·49 to -0·28]) but not the C-terminal region (r=0·02 [-0·10 to 0·15]) of CSP. The negative effect of maternal anti-CSP IgG in infants did not appear to be confounded by other malaria transmission-dependent variables. Interference between passive immunity and vaccine response is clinically significant and might affect the implementation of next-generation CSP-based vaccines for young infants and mothers as well as passive immunisation with human monoclonal antibodies. US National Institutes of Health, National Institute of Allergy and Infectious Diseases; PATH-Malaria Vaccine Initiative; Spanish Ministerio de Economía y Competitividad (Instituto de Salud Carlos III), European Regional Development Fund and European Social Fund; Fundación Ramón Areces; Spanish Ministry of Science and Innovation; and Generalitat de Catalunya (CERCA Program).