The Wells-Barkerville area of the Cariboo gold mining district is situated within the Quesnel Highlands on the eastern edge of the Interior Plateau in central British Columbia, Canada of the eastern Circum-Pacific volcanicmetallogenic belt. Recorded gold production from the area totals more than 4.0 million ounces, including an estimated 2.7 million ounces from placer mining from 101 creeks and 1.3 million ounces from lode mining. There are five principal types of lode gold deposits in the district; namely, auriferous pyrite replacement, including replacement in limestone and that in calcareous clastic rock; pyrite-quartz vein/veinlet lode gold, including strike vein, diagonal vein, orthogonal vein, and quartz veinlets; basalt-hosted auriferous pyrrhotite-pyrite lode gold; and associated gold in porphyry copper styles. This area is historically a famous gold production area in western Canada, including the initial alluvial gold and later and current lode gold. This original short article uses drilling results to illustrate that pyrrhotite in this area is the killer of gold. Wherever there is pyrrhotite, the gold grade is very poor or even contains no gold. In other words, gold grade is inversely related to pyrrhotite content. Then, the spatial distribution characteristics of the pyrrhotite anomaly zone(s) existing in this area were summarized, including the approximate thickness of zone(s). On this basis, several deep drill holes are recommended to verify whether there is considerable gold mineralization beneath the pyrrhotite anomaly zone(s).