A field investigation was carried out to evaluate the effect of herbicides and their mixtures on weeds in wheat (<italic>Triticum aestivum</italic> L.) cv. PBW-343. Minimum weed density per m<sup>2</sup> and weed dry weight (5.13 and 17.31g) was recorded with sulfosulfuron at 25g ha<sup>−1</sup> followed by clodinofop at 60g + metsulfuron methyl at 4g ha<sup>−1</sup> (5.19 and 18.45g), metribuzin at 200gha<sup>−1</sup>(5.85 and 25.98g), pendimethalin at 1000g fb 2,4-Dat400g ha<sup>−1</sup> (6.49 and 31.73g) and hand weeding twice(7.01 and 35g), respectively. Also, maximum weed control efficiency was recorded under sulfosulfuron at 25g ha<sup>−1</sup> (83.85%) followed by clodinofop at 60g + metsulfuron methyl at 4g ha<sup>−1</sup> (83.17%) and metribuzin at 200g ha<sup>−1</sup> (75.85%), respectively. All the weed control treatments recorded significantly higher harvest index than the weedy check (40.24). Among various herbicidal treatments, application of clodinofop at 60g + metsulfuron methyl at 4g ha<sup>−1</sup> recorded highest harvest index (41.91) followed by sulfosulfuron at 25 gha<sup>−1</sup> (41.83) and pendimethalin at 1000g fb2,4-Dat 400gha<sup>−1</sup> (41.25) respectively. The harvest index recorded under clodinofop at 60g + metsulfuron methyl at 4g ha<sup>−1</sup> and sulfosulfuron at 25 g ha<sup>−1</sup> was significantly at par with weed free (42.06).