The determination of the anthropogenic impact on the thermal regime of a megalopolis is discussed. The nominal boundaries of the megalopolis thermal effects are determined taking into account orographic and landscape effects and the variability of temperature difference between the center of the city and its suburbs. It is proposed to use the data of stations located within 40-50 km from the urban agglomeration boundaries for calculating the anthropogenic component of the urban heat island. The parameters of the heat island in Moscow are determined from the measurement data on maximum and minimum daily surface air temperature in 2012-2016, and their significant seasonal and intradaily variability is revealed. It is corroborated that anthropogenic causes for the higher air temperature in Moscow as compared with suburbs during the cold season are the release and loss of heat of heating systems; in the absence of snow cover the anthropogenic effect of these sources is enhanced by the thermal radiation of the urban surface.