The power supply company has invested a lot of money to enhance the reliability of the distribution network by improving the grid structure, increasing the level of distribution automation, and increasing the coverage of live operations. However, blind investment will cause a lot of waste of assets. In view of the current situation, this article firstly constructs a reliability calculation model based on the minimum path method, which considers the mutual influence of multiple methods. Then, from the perspective of the life cycle, a corresponding life cycle cost (LCC) model is established. Next, based on grid search, a multi-dimensional dynamic optimal configuration method of distribution network considering the full life cycle is presented. Finally, this paper takes a regional distribution network as an example, and verifies the validity of the model through simulation calculations. The research results can provide a theoretical basis for the investment of distribution network assets.