The autonomous driving industry is continuously dealing with safety-critical scenarios, and nonlinear model predictive control (NMPC) is a powerful control strategy for handling such situations. However, standard safety constraints are not scalable and require a long NMPC horizon. Moreover, the adoption of NMPC in the automotive industry is limited by the heavy computation of numerical optimization routines. To address those issues, this paper presents a real-time capable NMPC for automated driving in urban environments, using control barrier functions (CBFs). Furthermore, the designed NMPC is based on a novel collocation transcription approach, named RESAFE/COL, that allows to reduce the number of optimization variables while still guaranteeing the continuous time (nonlinear) inequality constraints satisfaction, through regional convex hull approximation. RESAFE/COL is proven to be 5 times faster than multiple shooting and more tractable for embedded hardware without a decrease in the performance, nor accuracy and safety of the numerical solution. We validate our NMPC-CBF with RESAFE/COL on digital twins of the vehicle and the urban environment and show the safe controller's ability to improve crash avoidance by 91%. Supplementary visual material can be found at https://youtu.be/_EnbfYwljp4.