In order to increase the noise immunity of data transmission systems, it is proposed to reduce the level of intersymbol interference by means of orthogonalizing the channel symbols. Orthogonalization is done through determining the orthogonality weight. Presented below is a calculation of the E-criterion for assessing the level of intersymbol interference for the proposed data transmission systems using the pulse-code modulation. For both systems, it was assumed that normalized Butterworth low-pass filters would be used as the shaping filter. It is shown that when signal-to-noise ratios exceed a certain critical value, weighted signal processing provides a lower bit error probability compared to the conventional processing technique. A general analytical expression for the orthogonality weight of channel symbols is given, which ensures a minimum bit error probability.