In this paper, two simple and effective construction methods are proposed to construct four-level design with large size via quaternary codes from some small two-level initial designs. Under the popular criteria for selecting optimal design, such as generalized minimum aberration, minimum moment aberration and uniformity measured by average Lee discrepancy, the close relationships between the constructed four-level design and its initial design are investigated, which provide the guidance for choosing the suitable initial design. Moreover, some lower bounds of average Lee discrepancy for the constructed four-level designs are obtained, which can be used as a benchmark for evaluating the uniformity of the constructed four-level designs. Some numerical examples show that the large four-level designs can be constructed with high efficiency.
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