Minimal Swelling Research Articles

Muscle-Sparing Six-Point Upper Blepharoplasty for Asian Male Patients.

Dermatochalasis is a consequence of aging and results in various problems, such as tired look, dry eye syndrome, or reduced vision. Although the demand for upper blepharoplasty is growing in the senescing world, the demand from male patients has been generally overlooked. Male patients prefer natural creases and fast recoveries, with minimal swelling. The authors introduce a novel method that will satisfy the demands of most male patients. This technique includes muscle-sparing skin incisions and fixation of folds through 6 slit incisions. This study retrospectively reviewed 40 Asian male patients who had been subject to this procedure. The patients were evaluated for fold attenuation, scar perception, and patient satisfaction; favorable outcomes with minimal complications were observed.

Insoluble hyaluronan films obtained by heterogeneous crosslinking with iron(III) as resorbable implants

We present water-insoluble hyaluronan films crosslinked by trivalent iron developed as potential resorbable implants. The films were crosslinked by sorption of ferric salt into solid HA films in water/2-propanol bath. These heterogeneously crosslinked films (het-FeHA) remained tough and dimensionally stable when rehydrated in saline. In contrast, films prepared by drying the well-known homogeneous ferric hyaluronate gels (hom-FeHA) softened upon rehydration and expanded rapidly. Differences between hom-FeHA and het-FeHA result from polymer network topology (dominant inter- or intra-molecular crosslink, respectively). Moreover, Mössbauer spectroscopy of het-FeHA revealed diiron complexes, while iron in the hom-FeHA was present exclusively as γ-FeOOH nanoparticles or amorphous FeOOH. The biocompatibility tests of het-FeHA did not show any adverse effect and the sample disintegrated within one day when implanted in mice peritoneum. In conclusion, we developed implantable hyaluronan-based free-standing film with minimal swelling that can be resorbed quickly enough to avoid induction of foreign-body reaction.

Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel

Post-surgical cardiac adhesions represent a significant problem during routine cardiothoracic procedures. This fibrous tissue can impair heart function and inhibit surgical access in reoperation procedures. Here, we propose a hydrogel barrier composed of oxime crosslinked poly(ethylene glycol) (PEG) with the inclusion of a catechol (Cat) group to improve retention on the heart for pericardial adhesion prevention. This three component system is comprised of aldehyde (Ald), aminooxy (AO), and Cat functionalized PEG mixed to form the final gel (Ald-AO-Cat). Ald-AO-Cat has favorable mechanical properties, degradation kinetics, and minimal swelling, as well as superior tissue retention compared to an initial Ald-AO gel formulation. We show that the material is cytocompatible, resists cell adhesion, and led to a reduction in the severity of adhesions in an in vivo rat model. We further show feasibility in a pilot porcine study. The Ald-AO-Cat hydrogel barrier may therefore serve as a promising solution for preventing post-surgical cardiac adhesions.

An unusual case of hip pain after total hip arthroplasty: A case report

Our goal is to draw attention to the inflammation of the iliopectineal bursa being a rare condition, which can cause lower limb swelling and anterior pain of the hip even years after total hip arthroplasty. A 67-year-old woman was admitted seven years after hip arthroplasty (cemented total endoprosthesis [TEP]) with swelling and feeling of excessive fullness of the lower extremity and with tolerable anterior hip pain. The physical examination and blood tests were non-specific for septic condition. Ultrasound showed a cystic mass in the inguinal region with a direct contact to the common femoral vein. Deep vein thrombosis was excluded. The single-photon emission computed tomography-computed tomography (SPECT-CT) was administered to decide the surgical plan, either making a bursa extirpation or making revision hip arthroplasty. The SPECT-CT excluded the possibility of aseptic loosening. Methylene blue was injected into the bursa intraoperatively which did not enter the strong pseudo-capsule of the joint and, therefore, we did not administer revision of the TEP, and the bursa was extirpated. Two weeks after the operation, the patient had no pain, was able to walk, and the swelling decreased. Four months after surgery, the pain and feeling of fullness disappeared, with minimal lower limb swelling. In conclusion, in case of increasing complaints of patients who left years behind without any problem following total hip arthroplasty, the pathogenic role of the iliopectineal bursa should be taken into account, after excluding more frequent causes such as aseptic loosening or periprosthetic joint infection. As long as we consider about a rare disease, we can find a solution to the patient’s complaint sooner.

A Case of Preterm Ovarian Hyperstimulation Syndrome Presenting With Vaginal Bleeding

Abstract Background: Preterm ovarian hyperstimulation syndrome (POHS) is a rare syndrome described in preterm female infants. This is associated with high serum estradiol and gonadotropin levels, multiple follicular ovarian cysts, and edema of the hypogastric, labial and upper leg regions. This usually occurs at 30 to 39 weeks post-conceptional age (PCA). Vaginal bleeding may or may not be present. We present an unusual case of POHS that had a delayed presentation at 5 months of age (45 weeks PCA) with vaginal bleeding. Case presentation: An extremely premature female infant presented with vaginal bleeding at 5 months of age. Workup revealed pubertal gonadotropins indicating ovarian hyperstimulation. She had mild swelling in the hypogastric region. No breast buds were palpable and there was no clitoromegaly. At the time LH (22.2 mu/ml), FSH (8.3 mu/ml), Estradiol (502.2 pg/mL), and Testosterone (111 ng/dL) were all highly elevated. Multiple ovarian follicles were visualized on her pelvic ultrasound, with generous ovarian dimensions: right ovary (3.6 x 1.6 x 1.9 cm, volume 5.7 cc) and left ovary (2.5 x 2.4 x 1.5 cm, volume 4.7 cc). The largest follicle measured 8.8 mm. The uterus was 3.3 x 1.3 x 1.7 cm, with endometrial stripe thickness of 3 mm. There was no endometrial or adnexal mass. Cosyntropin test showed adequate peak cortisol (32.6 mcg/dL). Her newborn screen had been normal. Serial monitoring of her lab work showed a decrease in her gonadotropin and estradiol levels. She had a recurrence of vaginal bleeding about 3 weeks after initial presentation. By 50 weeks PCA the bleeding had resolved and the LH (1.2 mu/ml), FSH (1.5 mu/ml), estradiol (36 pg/ml) had reduced considerably. Complete normalization of LH (1.2 mu/ml), FSH (1.5 mu/ml), E (36 pg/ml), and testosterone (<7 ng/dl) was demonstrated by 55 weeks PCA. Conclusion: POHS has been attributed to the immaturity of the hypothalamic-pituitary-gonadal axis in preterm infants. Vaginal bleeding has been described in one case [1] several weeks after breast enlargement and swelling of clitoral hood, labia majora, hypogastrium and upper legs. In our case the baby presented with vaginal bleeding at 45 weeks that recurred about 3 weeks later and resolved by 50 weeks, with only minimal swelling. This case underlines the need to be aware of this etiology and its varied presentation. [1] Preterm ovarian hyperstimulation syndrome presented with vaginal bleeding: a case report. Altuntas et al. J Pediatr Endocr Met; 273(3-4):355-358.

Synovial fluid mitochondrial DNA as a biomarker after naturally occurring intra-articular fracture

Synovial fluid mitochondrial DNA as a biomarker after naturally occurring intra-articular fracture

Minimally Invasive Approach for Total Temporomandibular Joint Replacement

<h3>Purpose</h3> This article describes a novel technique for replacing the temporomandibular joint (TMJ) with a prosthesis. The technique applies a simple endaural incision to approach the temporomandibular joint in order to place a total joint prosthesis. This is followed by small trochar site incisions for plating of the prosthesis. The technique was performed on 4 patients (8 TMJs). The potential benefits and complications of this approach are discussed throughout the article. <h3>Methods</h3> The single endaural approach was performed to replace bilateral TMJs in 4 patients in the Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at San Antonio. All 4 patients were followed up and examined once immediately after the procedure on postoperative day 1, 1 week postoperatively, and at varied times for up to 6 months. <h3>Results</h3> Postoperative exams were scheduled for 1-week and consecutive 1-month evaluations until symptoms resolved. Full head and neck exams were performed at each appointment. All patients had increased maximal interincisal opening (MIO) with very minimal swelling on day 1 of postoperative evaluation. They also reported a decrease in myofascial pain and headache. All 4 patients had temporary bilateral frontal and zygomatic facial nerve dysfunction that resolved with a mean time of 110 days. <h3>Conclusion</h3> All 4 patients in the research study had complications presenting as temporary bilateral frontal and zygomatic facial nerve dysfunction resolving within 4 months postsurgery. Directly after procedures were performed, the patients demonstrated increased function including greater mouth opening and conveyed experiencing diminished pain sensations. Although the preauricular endaural combined with a submandibular approach is considered the standard for temporomandibular joint (TMJ), the endaural only approach was adequate in this case providing immediate increases in MIO and decreases in patient perceived disability after the procedure. The single endaural method only created minor small incisions through the skin to extend to and increase the visibility of the appropriate area. It is a less invasive technique resulting in minimal tissue disturbance with immediately functional and aesthetically preferable results.

Un’opprimente tumefazione laterocervicale... da far mancare il respiro

Lymphatic malformations are low-flow vascular anomalies of the lymphatic system that occur in one out of 2-4,000 live births. They may be classified as macrocystic (diameter &gt; 1 cm), microcystic (diameter &lt; 1 cm) or mixed. Lymphatic malformations that are not prenatally diagnosed are typically diagnosed at birth or in early childhood. The clinical presentation can be quite variable, ranging from a focal area with minimal swelling to large involvement with compromise of adjacent structures. Up to 75% of lymphatic malformations are found in the cervicofacial region and their presence in the aerodigestive tract can lead to life-threatening airway obstruction. Lesions can grow slowly or rapidly and suddenly due to infection, trauma, bleeding or hormone level changes. The paper describes the case of a 9-month-old male infant with cervical macrocystic lymphangioma appeared during a febrile airway infection and misdiagnosed with bacterial lymphadenitis.

Subcutaneous Injection Performance in Yucatan Miniature Pigs with and without Human Hyaluronidase and Auto-injector Tolerability in Humans

Recombinant human hyaluronidase PH20 (rHuPH20) facilitates subcutaneous (SC) delivery of co-administered therapeutic agents by locally and transiently degrading hyaluronan in the SC space, and can be administered with therapeutics using a variety of devices. Two SC delivery studies were carried out to assess auto-injector (AI) performance, each in 18 Yucatan miniature pigs. Abdominal injections were administered using three auto-injectors of 1 mL (AI1) and 2 mL (AI2 and sAI2) with different injection speeds and depths (5.5–7.5 mm) and two pre-filled syringe (PFS) devices of 1 and 2 mL. The injection included a placebo buffer with and without rHuPH20 to evaluate the effect of rHuPH20 on SC injection performance. The feasibility of using similar devices to deliver a placebo buffer in humans was investigated. rHuPH20 was not studied in humans. In miniature pigs, postinjection swelling was evident for most PFS/AI injections, particularly 2 mL. Swelling heights and back leakage were typically lower with rHuPH20 co-administration versus placebo for most device configurations (1 or 2 mL PFS or AI). Auto-injections with versus without rHuPH20 also resulted in reduced swelling firmness and faster swelling resolution over time. Slow injections with rHuPH20 had shorter and more consistent injection time versus placebo. In humans, minimal injection site swelling and negligible back leakage were observed for 2-mL injections of placebo, while more erythema was observed in humans versus miniature pigs. Even at high delivery rates with PFS or AI, the addition of rHuPH20 resulted in improved SC injection performance versus placebo in miniature pigs.

Unusual location of molars called as kissing molars: A case report

Introduction: Kissing molars also called as “rosette formation”, these are unusual impacted teeth with their occlusal surfaces are in close apposition and the roots pointing in opposite direction. These are extremely rare conditions actually about less than thirty cases has been reported since now in the literature. Materials and Methods: This case report describes a patient who visited our outpatient clinic for pain over her left side of mandible for last one months. OPG was advised which showed unusual impacted left lower second and third molar relationship with their occlusal surfaces facing each other. Management by extraction of both second and third molars with proper surgical curettage of the site was done. Results: Postoperatively marked relief in the pain for the patient. Minimal postoperative swelling was observed immediate postoperative, which subsides after 5 days and there is no postoperative paraesthesia reported with relation to inferior alveolar nerve branch of trigeminal nerve and marginal mandibular nerve branch of facial nerve. Conclusion: Kissing molars are rare unusual pathological condition which needs proper treatment planning and management for proper surgical removal to prevent possible chances of postoperative paraesthesia with relation to inferior alveolar nerve branch of trigeminal nerve and marginal mandibular nerve branch of facial nerve. This report documents better surgical management of a patient with kissing molars. Keywords: Kissing molar, Impaction, Rare case, Management.

Ketamine for pain control of snake envenomation in Guinea: A case series

Snakebite envenomation is a global health crisis and is classified as a Category A neglected tropical disease by the World Health Organization (WHO). Snakebite envenomations account for a significant amount of morbidity and morbidity in tropical and subtropical regions. Recently, publications have illustrated the potential for snake envenomations causing post-traumatic stress disorder (PTSD) in a significant number of patients. Ketamine is on the WHO's list of essential medications and is used for a variety of pharmacologic applications including anesthesia and acute pain management. To date it has not been assessed for pain control in snakebite envenomations. Twelve patients who presented with severe pain secondary to Bitis, Causus, and Atractaspis envenomations were treated with low-dose intravenous ketamine. The patients included 7 males and 5 females with a median age of 37.5 (range 14–64) and a median presentation time of 5.75 h (range 5 min–96 h) after the initial bite occurred. Ten envenomations were presumed to have been caused by Bitis species resulting in extensive swelling and blistering of the affected extremities. One envenomation was presumedC. maculatus causing local swelling and pain. One envenomation was a presumed Atractaspis species causing significant local pain with minimal swelling. All patients expressed having significant pain but could not express the degree of their pain using an analogue pain scale. An initial median dose of 5 mg of ketamine (range 2.5–15 mg) was administered intravenously for pain control. Every patient expressed decreased pain and felt more comfortable within 1 min after administration of ketamine. Nine of the twelve patients only required a single dose. There were no adverse side effects. Ketamine appears to be an effective means of pain control for those suffering from painful envenomations. With minimal risk of significant side effects at acute pain management doses and the average cost per effective dose averaging between US$0.03–0.06, this may provide a cheap, safe, and effective solution for Sub-saharan Africa and other resource-limited settings. Controlled studies need to be done to critically assess our observations.

Phase Inversion-Induced Porous Polybenzimidazole Fuel Cell Membranes: An Efficient Architecture for High-Temperature Water-Free Proton Transport.

To cope with the demand for cleaner alternative energy, polymer electrolyte membrane fuel cells (PEMFCs) have received significant research attention owing to their high-power density, high fuel efficiency, and low polluting by-product. However, the water requirement of these cells has necessitated research on systems that do not require water and/or use other mediums with higher boiling points. In this work, a highly porous meta-polybenzimidazole (m-PBI) membrane was fabricated through the non-solvent induced phase inversion technique and thermal cross-linking for high-temperature PEMFC (HT-PEMFC) applications. Standard non-thermally treated porous membranes are susceptible to phosphoric acid (PA) even at low concentrations and are unsuitable as polymer electrolyte membranes (PEMs). With the porous structure of m-PBI membranes, higher PA uptake and minimal swelling, which is controlled via cross-linking, was achieved. In addition, the membranes exhibited partial asymmetrical morphology and are directly applicable to fuel cell systems without any further modifications. Membranes with insufficient cross-linking resulted in an unstable performance in HT-PEMFC environments. By optimizing thermal treatment, a high-performance membrane with limited swelling and improved proton conductivity was achieved. Finally, the m-PBI membrane exhibited enhanced acid retention, proton conductivity, and fuel cell performance.

Role of piezoelectric device in oral &amp; maxillofacial surgery

AbstractPiezosurgery is a relatively new technique that allows bone to be cut while preserving soft tissues, including nerves. It provided more favourable osseous repair and remodelling when surgical ostectomy and osteoplasty procedures were performed. Reduced blood loss, minimal swelling and edema were noted with various procedures when performed with this device. It is preferred in inaccessible sites; in areas where vital structures are in vicinity of the corticotomy sites. The unique feature of piezosurgery which makes it superior to the conventional technique is micro streaming and cavitation phenomenon. It also has millimetric cutting precision which adds to the accuracy of planning, prevents assistant fatigue, osseous thermal necrosis due to inbuilt irrigation at the cutting tip and permits ingenuity in osteotomy designs. We describe our experience with this device in different aspects of oral and maxillofacial surgery.

Endoscopy assisted extended curettage in a rare case of aneurysmal bone cyst involving the 2nd metatarsal of a child

&lt;p&gt;Aneurysmal bone cysts account for only 1% of all bone tumours and of these only a handful of reported cases occur in the foot. They can mimic other bone tumours on imaging studies, thus making histological diagnosis mandatory. Aneurysmal bone cyst of a metatarsal is very rare especially in children and only few cases have been reported in the literature. We report the novel management option for a rare case of an Aneurysmal bone cyst localized to the second metatarsal in a 5 years old boy who presented with limping, local pain, and minimal swelling in his left foot. Tissue diagnosis was confirmed on the basis of needle biopsy. Surgery was in the form of extended curettage using an endoscope with a high-speed burr and cautery. The remnant cavity was filled up with artificial bone graft. Histopathology analysis of the resected tissue was consistent with Aneurysmal bone cyst. There was complete healing at final follow-up at 2 years. Endoscopy assisted extended curettage appears to be an ideal treatment option as it provides a perfect visualisation of the interior of the entire cyst and use of cautery and burr more accurately under direct vision which potentially leaves only a minimal scope for recurrence. Use of artificial bone grafts instead of conventional autogenous bone grafts to reduce graft site morbidity in children and stimulate local foreign body reaction for enhancing residual tumour cell kill if any and also to promote bony sclerosis for healing.&lt;/p&gt;

EFFECTIVENESS OF DIODE LASER IN PERIODONTAL THERAPY: A CLINICAL STUDY

Now-a-days, almost every specialty area of dentistry is utilizing the powers of laser energy for therapeutic purposes. The diode laser is the most popular soft tissue laser and commonly used in dentistry. A diode laser with wavelengths ranging from 810 to 980 nm in a continuous or pulsed mode is used as a possible instrument for soft tissue surgery in the oral cavity. The 810 nm devices predominate in dentistry, whereas 810 nm is specific for hemoglobin absorption. Diode lasers have many advantages over traditional surgical and therapeutic techniques in addition to providing bloodless surgical and postsurgical course with minimal swelling, scarring, and others things noted are less pain, excellent hemostasis, rapid wound healing and bactericidal action with the minimally invasive procedure. In the present paper, we discuss various uses of the diode laser such as frenectomy, implant surgery, vestibular deepening, and gingival enlargement procedures in dentistry.&#x0D; Keywords: Diode laser; frenectomy, Implant Surgery, Vestibular Deepning, Gingival enlargement

Synthesis and characterization of a hyaluronic acid-based hydrogel with antioxidative and thermosensitive properties.

Peripheral arterial disease (PAD) is initiated by progressive atherosclerotic blockages of the arteries supplying the lower extremities. The most common presentation of PAD is claudication (leg pain and severe walking limitation), with many patients progressing to limb threatening ischemia and amputation. Biomaterial approaches are just beginning to be explored in the therapy of PAD with different materials now being evaluated for the delivery of cells or growth factors in animal models of PAD. A biomaterial matrix optimized for minimally invasive injection in the ischemic leg muscles of patients with PAD is urgently needed. There are several important requirements for optimal delivery, retention, and performance of a biomaterial matrix in the mechanically, histologically, and biochemically dynamic intramuscular environment of the PAD leg. Ideally, the material should have mechanical properties matching those of the recipient muscle, undergo minimal swelling, and should introduce properties that can ameliorate the mechanisms operating in PAD like oxidative stress and damage. Here we have developed an injectable, antioxidative, and thermosensitive hydrogel system based on hyaluronic acid (HA). We first synthesized a unique crosslinker of disulfide-modified poloxamer F127 diacrylate. This crosslinker led to the creation of a thermosensitive HA hydrogel with minimal swelling and muscle-matching mechanical properties. We introduced unique disulfide groups into hydrogels which functioned as an effective reactive oxygen species scavenger, exhibited hydrogen peroxide (H2O2)-responsive degradation, and protected cells against H2O2-induced damage. Our antioxidative thermosensitive HA hydrogel system holds great potential for the treatment of the ischemic legs of patients with PAD.

Efficacy of Various Routes of Dexamethasone Administration in Reducing Postoperative Sequelae Following Impacted Third Molar Surgery.

Aim:To compare the efficacy of intravenous (IV), intramassetric (IM) submucosal (SM) routes & oral routes of dexamethasone administration post impacted third molar removal surgery.Type of Study:Prospective randomized comparative clinical study.Materials and Method:This prospective comparative study included 60 patients with Class II and position B type of impaction (according to Pell and Gregory's classification). Patients were randomly divided into 4 groups. Group A, B, C & D patients received 8mg dexamethasone immediately post-surgical tooth removal via the IV, SM and IM route & oral respectively. Assessment of swelling, mouth opening and pain was done at intervals of 1st, 3rd and 7th post-op days.Results:The average age of the patients was 27 years. The mean time taken was 20 mins 40 seconds. The IV group showed minimal swelling and better pain control on the 3rd post op day (statistically significant). All 4 routes showed comparable mouth opening results.Conclusion:IV administration of dexamethasone post third molar surgery has been the traditional way because of its faster onset of action and increased efficacy; IM and SM routes are also comparably effective although oral route had the best patient acceptance.

Functional outcome following internal fixation of capitellum fracture in a young adult by Herbert screws- A case report

A 25 yrs old male presented to emergency with H/o motorcycle accident, injury mechanism being fall on outstretched hand with elbow in hyperextension. Post-injury patient complained of severe pain in left elbow region with loss of elbow flexion. On examination minimal swelling was noted at elbow with tenderness over lateral aspect. Radiographs of AP & Lat views revelead large capitellar fracture involving articular surface of lateral condyle. CT Scan was done to evaluate fracture in detail and also to rule out other injuries around elbow. On next day of admission open reduction and reattachment of large capitellar fragment was done with two headless screws {Herbert screws}. Post-op patient was followed for six months with Xrays. The initial loss of flexion improves over three month period with intensive physiotherapy. Terminal 20.degree of flexion was not achieved even after completion of 6 months duration but this loss of not of much functional or aesthetic significance

Cellulose hydrolysis using ionic liquids and inorganic acids under dilute conditions: morphological comparison of nanocellulose.

The preparation of cellulose nanocrystals (CNCs) from cellulose extracted from cotton gin motes (CGM) using an ionic liquid (1-butyl-3-methylimidazolium chloride, [BMIm]Cl) under dilute conditions is reported. The concurrent process involves minimal swelling of cellulose with an ionic liquid and hydrolysis of the cellulose initiated by the addition of either phosphoric (H3PO4), hydrochloric (HCl), or sulfuric (H2SO4) acid. The obtained nanocrystals had similar physical properties (e.g. crystallinity) to the counterparts prepared under conventional conditions and exhibited superior thermal properties for sulfate CNCs. Additionally, the obtained CNCs had low surface functionalization, yet were colloidally stable for >90 days, which is a desirable trait for post-functionalization of CNCs. This process represents a general strategy utilizing dilute ionic liquids in the preparation of nanocellulose under mildly acidic conditions.

Olefin metathesis-crosslinked, bulky imidazolium-based anion exchange membranes with excellent base stability and mechanical properties

To improve the mechanical properties of anion exchange membranes (AEMs) with bulky imidazolium cations, a series of anion-conductive poly(2,6-dimethyl-phenylene oxide)s (PPO)s with crosslinkable terminal double bonds were synthesized by the Menshutkin reaction. Following crosslinking via olefin metathesis at room temperature catalyzed by a Grubb's second generation catalyst, tough, transparent, and flexible PPO-based AEMs were obtained. The crosslinked AEMs exhibited good mechanical properties (tensile strength at maximum load of 20.8–49.9 MPa and values of elongation at break of 1.5–3.0%) though their bulky imidazolium cation groups which could destroy the film-forming ability of polymer. And the obtained mechanical properties were considerably better than those of the non-crosslinked AEMs with a similar architecture, which broke into small pieces during the process of membrane fabrication using solvent casting. Furthermore, the crosslinked AEMs exhibited an extremely low water uptake (up to 13.9 wt% at 80 °C) and minimal swelling (<7% at 80 °C), attributed to the high-density crosslinking network. A high bromide conductivity (22.9 mS/cm at 80 °C) was achieved despite the low water uptake for the crosslinked AEM. Moreover, long-term alkaline stability testing in 1 M NaOH at 80 °C, no obvious degradation of the imidazolium ring was observed, with the conductivity of aged crosslinked membranes remaining at ~100% after 960 h. It was assumed that the bulky substituents at the C2, C4, and C5 positions of imidazolium cations and the crosslinked architecture prevented H2O and/or OH− from attacking the cationic center. Moreover, the AEM fuel cell performance and durability was further explored for the membrane electrode assembly (MEA) with crosslinked and uncrosslinked bulky imidazolium-based ionomers in catalyst layers. An optimistic cell performance (a peak power density of 173 mW/cm2 at 410 mA/cm2) and improved short-term durability at a constant current density of 200 mA/cm2 were obtained for the crosslinked ionomers, and its lifetime was ca. 3 times longer than that of benzyltrimethylammonium functionalized PPO ionomer.