Minimal Reduction Research Articles

Aortic Regurgitation: From Valvular to Myocardial Dysfunction.

Chronic aortic regurgitation (AR) leads to volume overload in the left ventricle (LV), which is well tolerated for years. In this condition, the LV usually dilates with minimal reduction in the ejection fraction (EF), even in the absence of symptoms. Echocardiography is the primary imaging test used to quantify AR. However, no single assessment of Doppler measures is accurate and precise in individual patients; therefore, the integration of multiple parameters is necessary. Recent guidelines recommend surgical treatment for severe AR in patients who are symptomatic or have an LVEF < 55% and an end-systolic diameter > 50 mm. Nevertheless, advances in imaging technology have improved the quantification of AR and the assessment of LV subclinical dysfunction. It is widely recognized that patients who undergo aortic valve replacement/repair (AVR) due to symptoms or a low LVEF experience worse outcomes than those undergoing AVR for non-Class I indications. In fact, subclinical irreversible myocardial damage may occur in clinically well-compensated and closely monitored patients while awaiting formal surgical indications. This condition could be prevented by the use of multimodal imaging parameters, in particular longitudinal LV strain and magnetic resonance imaging. In addition, better cut-off values for mortality predictors should be established. This review aims to identify simple models that integrate several echocardiographic and cardiac magnetic resonance-derived parameters to predict the optimal timing of surgical treatment in asymptomatic patients with chronic severe AR.

Effects of oil heat treatment on poplar wood properties: A pilot scale study

Pilot-scale oil heat treatment was conducted to enhance the quality of poplar wood obtained from a fast-growing plantation. Three target temperatures, namely 180, 190, and 200 ˚C, were chosen for the oil heat treatment process. Clear, small specimens were cut from the lumber, following the prescribed standards for assessing wood quality. Light microscopy revealed the ruptures and deformation of the wood cell wall as the treatment temperature increased. The volumetric swelling of the treated specimen decreased proportionally with the increase in treatment temperature. The impact of oil heat treatment on the mechanical properties of wood varied depending on the specific type of mechanical strength and processing temperature. The modulus of rupture, toughness, and hardness of the treated specimens drastically decreased at 200°C. However, the specimens treated at 200°C exhibited much lower mass loss during the fungal decay test. The results of the analytical test showed an increase in the crystalline cellulose content and thermal stability of the treated wood, due to the thermal degradation of hemicelluloses and amorphous regions of cellulose. Overall, it is concluded that oil heat treatment of poplar wood in the optimal temperature is an efficient approach to upgrade its quality with minimal reduction in mechanical strength.

Assessing gully erosion susceptibility dynamics using information value and hazard index methods: A case study of Agulu-Nanka watershed, Southeast Nigeria

Gully erosion is one of the major causes of land degradation leading to the loss of productive lands globally. The Benue Trough in Nigeria is plagued with the problem of gully erosion, with a myriad of natural and anthropogenic factors considered as contributory factors. In this study, quantitative and qualitative methods were combined to evaluate gully susceptibility in the Agulu-Nanka watershed located in the lower part of Benue Trough between 2000 and 2018. Landsat 7 and 8 images, Digital Elevation Model (DEM), geological, soil, and rainfall erosivity maps were used to generate the gully erosion controlling factors including vegetation cover, lithology, soil, land use/cover, slope, curvature, aspect and rainfall erosivity. Additionally, high resolution image was used to develop gully inventory map. The information value method was used evaluate the influence of various classes of gully erosion controlling factors on gully distribution in the watershed. This enabled objective derivation of weights for the various classes of these factors. Information value analysis reveal that low percentage vegetation cover (<10 %), Ameki Group lithological unit, high slope gradient (17 − 43°) and Dystric Fluvisols soil type have the highest influence on gully erosion in the watershed. Since the information value method does not consider interrelationship between factors, the rank sum technique was used to derive factor weights based on the relationship between the factors. To develop the gully susceptibility map for the Agulu-Nanka watershed for the years 2000 and 2018, the erosion controlling factors were integrated using factor class weights derived through information value and factor weights derived through rank sum method. The analysis of gully erosion hazard maps show that approximately 48 % of the watershed was under low erosion risk over the period of 18 years. Areas under moderate, high and severe erosion risk decreased from 27.45 %, 9.45 % and 0.27 % of the watershed in year 2000, to 21.30 %, 8.41 %, and 0.20 % of the watershed respectively in 2018. On the other hand, the areas under negligible erosion risk increased from 14.69 % in year 2000, to 21.26 % of the watershed in 2018. The validation of the gully erosion susceptibility map for years 2000 and 2018 using the Receiver Operating Curve (ROC) showed ROC-AUC values of 0.81 % and 0.88 % respectively suggesting good model results. While the result of study indicates that restoration efforts through afforestation is yielding some result, the minimal reduction in the size of areas under severe and high gully erosion susceptibilities indicate that additional mitigation measures need to be combined with intensified afforestation efforts to effectively combat gully erosion in the watershed.

Ethraid: A Simple Method for Characterizing Long-period Companions Using Doppler, Astrometric, and Imaging Constraints

We present ethraid, an open-source Python package designed to measure the mass (m c ) and separation (a) of a bound companion from measurements covering a fraction of the orbital period. ethraid constrains m c and a by jointly modeling radial velocity, astrometric, and/or direct imaging data in a Bayesian framework. Partial orbit data sets, especially those with highly limited phase coverage, are represented well by a few method-specific summary statistics. By modeling these statistics rather than the original data, ethraid optimizes computational efficiency with minimal reduction in accuracy. ethraid uses importance sampling to efficiently explore the often broad posteriors that arise from partial orbits. The core computations of ethraid are implemented in Cython for speed. We validate ethraid's performance by using it to constrain the masses and separations of the planetary companions to HD 117207 and TOI-1694. We designed ethraid to be both fast and simple, as well as to give broad, “quick look” constraints on companion parameters using minimal data. ethraid is pip installable and available on Zenodo and GitHub.

The usability of green deep eutectic solvents in hollow fiber Liquid-Phase microextraction for the simultaneous extraction of analytes of different Natures: A comprehensive study

In the current study, a wide range of deep eutectic solvents (DESs) with different properties (hydrophilic, hydrophobic, ionic, and nonionic) were prepared in the initial phase. Subsequently, an assessment was conducted to evaluate some characteristics of the produced DESs, including their stability at room temperature and their capacity to extract three distinct types of analytes (anionic, cationic, and non-ionic) simultaneously through hollow fiber-liquid phase microextraction (HF-LPME) technique. To carry out the extraction procedure, the prepared DESs were inserted into the pores (as supported liquid membrane (SLM)) and lumen of hollow fiber membrane (HF) to apply two-phase and three-phase HF-LPME techniques. After a thorough evaluation, the three-phase HF-LPME technique (HF(3)-LPME) was chosen by using a mixture of menthol/TBAB-based hydrophobic DES (DES-35) as SLM and the mixture of malic acid/citric acid/water-based hydrophilic DES (DES-2) as an extraction solvent in the lumen of HF. All factors affecting the extraction recovery (including pH, extraction time, extraction temperature, stirring speed, and salt effect) were optimized utilizing the one-variable-at-a-time (OVAT) methodology. After applying the extraction procedure, all extracted samples were analyzed using the UV–Vis spectrometer and results were recorded at different wavelengths including 655 nm for Methylene blue, 550 nm for Amaranth, and 375 nm for Quercetin. The calibration graphs showed linearity in the range of 20.0–1500 µg/L, with a limit of detection of 6.2–15.1 µg/L and correlation coefficients higher than 0.9913 for the studied analytes. Moreover, the intra-day RSD, inter-day RSD, preconcentration factor (PF), enrichment factors (EF), and extraction recoveries (ER%) were obtained in the range of 3.1–4.8, 3.8–6.7, 125, 102.9–111.4, and 82.3–89.1 %, respectively. The use of the selected DES in the HF-LPME methodology resulted in an ecologically friendly strategy, as evidenced by the use of green metrics from the SPMS tool. The proposed strategy is also considered environmentally friendly due to its use of minimal solvents, waste reduction, and low energy consumption. The proposed technique effectively and simultaneously extractedmethylene blue, amaranth, and quercetin analytes in different real samples.

Boosting UV responsivity of silicon photodetectors through efficient quantum-cutting with La3+, Yb3+ co-doped perovskite quantum dots

Quantum cutting involves the absorption of a single high-energy photon, followed by the release of its energy through the emission of two or more lower-energy photons. This approach holds promise as a method to improve the ultraviolet (UV) performance of silicon photodetectors (Si PDs). In this study, we successfully fabricated La3+, Yb3+ co-doped CsPbClBr2 perovskite quantum dots (PQDs) using a modified hot-injection method, achieving a remarkable photoluminescent quantum yields (PLQYs) of 181 %. Subsequently, we spin-coated a film of La3+, Yb3+ co-doped CsPbClBr2 PeQDs, serving as a light conversion material, onto the front surface of Si PDs. The resulting configuration exhibited enhanced responsivity (0.131 A/W) and external quantum efficiency (55.6 %), long-term stability at 360 nm, and expanded responsiveness into the deep UV region (200 nm). Simultaneously, the responsivity and external quantum efficiency in the visible and near-infrared regions exhibited minimal reduction. This significant performance can be attributed to two key factors: (1) The higher efficient quantum cutting PLQYs (181 %) of La3+, Yb3+ co-doped CsPbClBr2 PeQDs and (2) the presence of fewer traps and a larger tolerance factor resulting from La3+ and Yb3+ co-doping.

Enhanced bactericidal performance of textiles through compound antimicrobial agents.

This study aims to explore the essential functional requirements associated with controlling the proliferation of microbes in the domain of textiles used in public health areas. Herein, three antimicrobial agents, specifically iodopropylbutylcarbamate (IPBC), 1-hydroxypyridine-2-thioketone zinc (ZPT), and 2-octyl-3-isothiazolinone (OIT), were chosen for fabric finishing based on their notable effectiveness, minimal toxicity, cost-efficiency, and chemical stability. Utilizing Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) as representative bacterial strains, the Minimum Inhibitory Concentration (MIC50) of individual and combined antimicrobial agents was measured, and their antimicrobial effectiveness was rigorously evaluated. Concurrently, the antimicrobial effectiveness, whiteness, and mechanical durability of the fabric following antimicrobial treatment were thoroughly examined. The results demonstrate that some combinations of the three antimicrobial agents elicit additive effects on both S. aureus and E. coli. Notably, at an equivalent ratio of IPBC, ZPT, and OIT and a total concentration of 0.2 wt. %, the inhibition rates against both bacterial strains surpass 99%. Upon application to nylon fabric, the treated material demonstrates significant antimicrobial properties, with minimal reduction observed in the whiteness and tensile strength of the treated nylon. This study provides practicable strategies relevant to the production of textiles endowed with antimicrobial properties.

Farmer response to policy induced water reductions: Evidence from the Colorado River

Surface water supplies are becoming increasingly strained, pushing policy makers to find solutions to facilitate reductions in water use though there is limited evidence on how farmers respond to policy induced variation in surface water supplies. This paper uses a difference-in-differences framework to compare the response of farmers to a bundle of policies reducing deliveries from the Colorado River by 35%. I find that on average, farmers reduce the amount of land planted but plant more water intensive crops leading to a minimal reduction in total estimated water use compared to the counterfactual. Additionally, there is strong suggestive evidence that farmers are using groundwater to offset a significant amount of the surface water loss. These findings have important consequences for understanding the relative trade-offs policy makers face when implementing policies that protect surface water sources.

Biomanufacturing of ricinoleic acid from castor oil using immobilized lipase of Pseudomonas guariconensis as biocatalyst

The efficacy of castor oil hydrolysis to ricinoleic acid by a Pseudomonas guariconensis lipase immobilized on glutaraldehyde-activated ferromagnetic nanoparticles was investigated. The prepared nanoparticles were characterized using FTIR and DLS and used as a novel biocatalyst for the production of ricinoleic acid. The optimum reaction conditions for the hydrolysis reaction by Fe3O4-APTES-Glu-lipase were optimized through the response surface methodology (RSM) which resulted in a maximum conversion of 62.5 ± 0.76%. The optimized reaction conditions are the temperature of 40 0C, pH 9, water: oil ratio of 4:1, and biocatalyst concentration of 4% w/w of the oil used. Moreover, the immobilized biocatalyst showed high stability with minimal reduction of hydrolytic efficiency after six consecutive cycles of reuse.

The Utilization of Date Palm (Phoenix dactylifera) Leaf Fiber as a Main Component in Making an Improvised Water Filter

Access to clean and safe water is known to be an obstacle for many people globally, leading to the necessity of creating a water filtration method that is feasible and can be made even in rural and developing areas. This study aimed to make an Improvised Water Filter that is sustainable, cost-effective, and locally sourced, using Date Palm (Phoenix dactylifera) leaf fiber as a main component. The Date Palm leaf fibers were extracted by boiling, drying, and manual scraping. The study strived to investigate the capability of Date Palm leaf fibers alone to improve water quality by testing fungal presence through culturing, physical pollutants by utilizing a microscope, and pH level and salinity levels using a calibrated multitester. The research findings proved the effectiveness of the Improvised Water Filter specifically by reducing fungal colonies by 4.33 and 8.33 in saltwater and contaminated water respectively, eliminating the majority of the physical pollutants by 53.5 micrometers and by 256.3 micrometers, neutralizing the water pH levels by 0.60 and by 0.78, neutralizing the salinity levels by 149.67 ppm and by 338.33 ppm, and exhibiting reliable durability and functionality properties in terms of its structure and filtering media condition with a water flow rate of 1.1L/min and 1.02L/min, and a minimal reduction in the weight of the filtering media by 3.7g and by 3.3g in saltwater and contaminated water respectively. The Improvised Water Filter has effectively filtered and neutralized the water samples, improving the water quality. Future researchers are recommended to conduct comparative studies involving Date Palm (Phoenix dactylifera) and other natural materials, examining filtration capabilities and efficiency, material durability, and by further investigating other water quality indicators to create an improved product that can produce potable and safer water.

A comprehensive study on mechanical properties, durability, and environmental impact of fiber-reinforced concrete incorporating ground granulated blast furnace slag

Concrete pavements are integral to sustainable infrastructure, offering longevity and resilience in construction and transportation. This study focuses on optimizing concrete pavements through the incorporation of steel and carbon fibers with Ground Granulated Blast Furnace Slag (GGBS) to enhance mechanical strength, reduce fracture development, and minimize carbon emissions. Utilizing 25 mixing designs with a consistent water-to-cement ratio of 0.40, varying ratios of GGBS, steel fibers, and carbon fibers (0.5 %, 1 %, and 1.5 % based on concrete volume) were explored. A comprehensive evaluation, including slump, compressive strength, flexural strength, split tensile strength, water absorption, abrasion resistance tests, carbon dioxide emissions, and cost analysis, was conducted at different curing stages. Results revealed a decline in compressive strength for all mix designs at 28 days, attributed to reduced cement strength with GGBS substitution. The 1.5 % steel fiber and 50 % GGBS mix demonstrated minimal compressive strength reduction (30.1 MPa, 5.5 % less than control), outperforming other mixtures. Steel fibers surpassed carbon fibers, likely due to \\erior distribution. Notably, 1.5 % steel fibers showed superior results, particularly with 50 % GGBS. Compressive strength generally increased with GGBS content, except for 1 % fibrous samples where 40 % GGBS produced optimal results. At 90 days, compressive strength increased for most designs, with G50S1.5 exhibiting over 38 % growth compared to the control. Steel fiber-containing samples outperformed carbon fiber-containing ones, showcasing the efficacy of steel fibers in enhancing compressive strength. Split tensile strength generally decreased, but steel fibers improved it, emphasizing their positive influence. Flexural strength increased in 28 and 90 days, with steel fiber-containing designs outperforming. G30S1.5 showed the most significant increase (33.3 %) at 28 days, and G30S1.5 exhibited the highest growth (32.22 %) at 90 days. Abrasion resistance tests indicated steel fibers and GGBS positively impacted abrasion reduction. G50S1.5 demonstrated the highest abrasion resistance (25 % increase over control). The environmental evaluation revealed lower CO2 emissions for GGBS-containing designs. G50S0.5 showed a 40.34 % reduction compared to the control sample. Cost analysis showed GGBS reduced costs, but fiber addition, particularly carbon fibers, increased costs. G30C1.5 had the highest cost increase (208.5 %), while G50S1.5 showed a marginal rise (3.9 %) compared to the control. Therefore, steel fibers in concrete pavements offer improved mechanical properties, durability, and reduced environmental impact, making them a viable choice despite a slight increase in cost. Conversely, carbon fibers are cautioned against due to their higher cost and inferior mechanical properties.

P068 The Use of Virtual Reality Headsets instead of Entonox for Paediatric Patients undergoing Steroid Joint Injections or Venepuncture / Cannulation

Abstract Background/Aims Entonox has traditionally been used for patients with Juvenile idiopathic arthritis (JIA) who require intra-articular joint injections (IAIs). However, Entonox is now the third most misused drug especially in school age children and young people (CYP). Entonox also has an environmental impact. In addition, Entonox has side-effects including euphoria, disorientation, nausea and vomiting. Recently there has been increased awareness of the risks of Vitamin B deficiency associated with prolonged Entonox use which can lead to neurological toxicity. These factors have led us to consider virtual reality (VR) devices as an alternative for patients requiring IAIs. The VR headset we used is a class one medical device that can provide both reduction in anxiety levels and pain relief in patients needing anxiety-provoking or painful procedures such as IAIs. Aims: To trial the use of VR devices in a Paediatric Rheumatology Service and to assess effectiveness in reducing anxiety and pain when used during IAIs and cannulation / venepuncture. Methods A pragmatic pilot study of VR headset use was carried out from November 2022 until September 2023. All CYP undergoing IAIs without GA were offered either Entonox sedation or VR headset distraction. Each CYP using the VR headset was asked to score anxiety and pain levels before and after the procedure using a Likert scale. Patient demographics were also collected (age and gender). Results A total of 42 patients attended for IAI’s during the study window between the ages of 7 and 16. Thirty-three opted to use the VR headset. Nine opted for Entonox. An additional 22 patients opted to use the VR headset for venepuncture / cannulation. The 64 users of the VR headset reported an average 47.8% reduction in anxiety and a 0.8% reduction in pain. Conclusion The study demonstrated that the use of a VR headset reduces anxiety in CYP having painful procedures. A minimal reduction in pain however was reported. This may be due to some patients having low pre procedural pain scores. The terms of the headset loan limited the questions that could be set for data collection. It has therefore not been possible to separate results from children who underwent IAIs or venepuncture / cannulation. We also did not collect comparative scores from the Children and young people who chose to use Entonox. Funding has now been secured for the VR headset and we are carrying out a prospective evaluation, including feedback from patients and staff, into the role of VR devices in managing situations involving procedural anxiety. Disclosure H.C. Lee: None. S. Leach: None. D. Hawley: None. N. Barker: None.

Biodegradable thermochromic polylactic acid (PLA) sensor

Abstract This study investigates the development of polylactic acid (PLA) by incorporating thermochromic black pigments (TCB) at varying concentrations of 0, 0.5, 1, 2 and 3 wt% through the process of melt blending. The color transition and reversion behaviors of the resulting specimens were examined at different temperatures (−10, 10, 30, 35 and 50 °C) using colorimetric analysis. Additionally, mechanical properties, thermal characteristic and thermal stability were assessed through tensile testing, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), respectively. The study revealed that an increase in TCB concentrations led to a reduction in lightness (L*). Higher pigment content enhanced thermochromic properties, resulting in more pronounced color changes. The total color difference (ΔE) remained reproducible over five cycles of heating and freezing, and this reproducibility persisted after thermal aging. Tensile strength and elongation at break exhibited improvement with increasing pigment content. Glass transition temperature (Tg) and melting temperature (Tm) of the thermochromic samples showed minimal reduction compared to that of neat PLA, which is 64.2 °C. Crystallinity degree (Xc) increased slightly by 0.2–0.92 %. The thermal stability of the PLA matrix was only marginally affected by the presence of thermochromic pigments.

Biotechnological Approach of Technological Advancements for Sustainable Probiotic Bread Production

The pursuit of probiotic-enriched bread, driven by the dual objectives of enhancing nutritional value and promoting health while ensuring sustainability, has spurred significant research and technological advancements. However, a persistent challenge lies in preserving the viability of microorganisms throughout the rigorous processes of production, storage, and exposure to the stomach’s acidic environment. This study investigates biotechnological innovations for sustainable probiotic bread production, conducting a thorough review of probiotic encapsulation methods and analyzing prior research on the viability of encapsulated probiotics in bread across different baking conditions and storage periods. Encapsulation emerges as a promising strategy, involving the protection of microorganisms with specialized layers, notably multilayered alginate-chitosan coatings, to shield them from degradation. Studies suggest that encapsulated probiotics, particularly the L. casei 431 strain within smaller-sized products subjected to shorter baking times, exhibit minimal viability reduction. Moreover, incorporating microcapsules into the dough, rather than post-baking surface application, further mitigates bacterial losses during storage. Despite these advancements, further investigations are necessary to identify strains resilient to processing, storage, and consumption while prioritizing sensory attributes to meet consumer preferences. Ultimately, research in probiotic bread production aims for a sustainable approach, placing significant emphasis on health considerations and disease prevention. Implementing encapsulation technology aligns with consumer demands for healthy, environmentally friendly products, highlighting the urgent need for innovation in this field with a focus on sustainability.

Virtual Visit Evaluation from the Perspectives of Physicians and Patients: A Qualitative Study in a Developing Country

Introduction: Many patients, especially in rural and remote areas, face the problem of unavailability of specialists. Today, virtual visit technology is used by the public as a solution to solve the problem of lack of access to specialists and reduce unnecessary costs. Therefore, the purpose of this study is to identify the strengths, weaknesses, opportunities and threats (SWOT) of the virtual visit system from the point of view of physicians and patients.Material and Methods: This cross-sectional qualitative study was conducted from June to August 2023 in Kermanshah. Semi-structured and in-depth interviews were conducted face-to-face with five physicians and ten patients. All interviews were transcribed verbatim. Data analysis utilized the SWOT framework and the software Atlas.ti8.Results: The results of this study revealed that virtual visits have strengths such as minimal infrastructure requirements, cost reduction, and human resource efficiency. Weaknesses include the absence of physical examination, reduced quality of examinations, and limitations for certain patients. Opportunities include quick visits in remote areas and a decrease in health disparities, while threats encompass potential privacy breaches, violation of patient information confidentiality, lack of motivation among health users, and limited access to technology.Conclusion: Based on the study findings, in healthcare crises, telemedicine technology proves effective in providing primary healthcare services. Telemedicine plays a crucial role in health by enhancing access and reducing costs. To optimize this process, a comprehensive strategy in digital health, involving infrastructure investment and stakeholder feedback, is evident. Sharing experiences and addressing challenges empower managers to enhance healthcare services through virtual visits, adapting to the prevailing conditions.

Translational research of boron neutron capture therapy for spinal cord gliomas using rat model

Boron neutron capture therapy (BNCT) is a type of targeted particle radiation therapy with potential applications at the cellular level. Spinal cord gliomas (SCGs) present a substantial challenge owing to their poor prognosis and the lack of effective postoperative treatments. This study evaluated the efficacy of BNCT in a rat SCGs model employing the Basso, Beattie, and Bresnahan (BBB) scale to assess postoperative locomotor activity. We confirmed the presence of adequate in vitro boron concentrations in F98 rat glioma and 9L rat gliosarcoma cells exposed to boronophenylalanine (BPA) and in vivo tumor boron concentration 2.5 h after intravenous BPA administration. In vivo neutron irradiation significantly enhanced survival in the BNCT group when compared with that in the untreated group, with a minimal BBB scale reduction in all sham-operated groups. These findings highlight the potential of BNCT as a promising treatment option for SCGs.

Evolution of volatile compounds of baked dried tofu during catalytic infrared baking process and their correlation with relevant physicochemical properties.

Energy-saving and low-carbon baking processes, as well as the need to determine the flavor-forming mechanisms of baked dried tofu, are becoming increasingly necessary. The application of emerging catalytic infrared radiation (CIR) technology in baking of dried tofu is considered of high interest due to the low energy consumption and high baking efficiency compared to traditional baking methods. Hence, this study aimed to investigate the evolution of aroma compounds in baked dried tofu during the CIR baking process and reveal relevant relationships between physical qualities, potential flavor precursors and key volatile compounds. The results showed that the surface color of dried tofu gradually turned an appetizing golden yellow color during the rapid heating process, caused by the uniform infrared radiation from the radiant emitters. Meanwhile, the moisture of dried tofu experienced minimal reduction and the hardness of dried tofu gradually increased with the formation of crust on the surface. In addition, 49 volatile compounds were identified by headspace solid-phase microextraction-gas chromatography-mass spectrometry and 13 substances - 1-hexanol, 1-octen-3-ol, 1-pentanol, heptanal, nonanal, hexanal, (E,E)-2,4-decadienal, (E,Z)-2,4-decadienal, octanal, (E)-2-octenal, (E)-2-nonenal, 2-heptanone and 2-pentylfuran - were confirmed as key aroma compounds. Moreover, the amino acids aspartic acid, glutamic acid, isoleucine, lysine and arginine, and the fatty acids butyric, caprylic, capric, tridecanoic, stearic, oleic and linolenic were responsible for the unique flavor of CIR-baked dried tofu. Consequently, the findings can provide a scientific basis for manufacturers to achieve precise quality control and large-scale production of CIR-baked dried tofu products. © 2024 Society of Chemical Industry.

Level One Trauma Center Proliferation May Worsen Patient Outcomes.

From 2013 to 2020, Arizona state trauma system expanded from seven to thirteen level 1 trauma centers (L1TCs). This study utilized the state trauma registry to analyze the effect of L1TC proliferation on patient outcomes. Adult patients age≥15 in the state trauma registry from 2007-2020 were queried for demographic, injury, and outcome variables. These variables were compared across the 2 time periods: 2007-2012 as pre-proliferation (PRE) and 2013-2020 as post-proliferation (POST). Multivariate logistic regression was performed to assess independent predictors of mortality. Subgroup analyses were done for Injury Severity Score (ISS)≥15, age≥65, and trauma mechanisms. A total of 482,896 trauma patients were included in this study. 40% were female, 29% were geriatric patients, and 8.6% sustained penetrating trauma. The median ISS was 4. Inpatient mortality overall was 2.7%. POST consisted of more female, geriatric, and blunt trauma patients (P < .001). Both periods had similar median ISS. POST had more interfacility transfers (14.5% vs 10.3%, P < .001). Inpatient, unadjusted mortality decreased by .5% in POST (P < .001). After adjusting for age, gender, ISS, and trauma mechanism, being in POST was predictive of death (OR: 1.4, CI:1.3-1.5, P < .001). This was consistent across all subgroups except for geriatric subgroup, which there was no significant correlation. Despite advances in trauma care and almost doubling of L1TCs, POST had minimal reduction of unadjusted mortality and was an independent predictor of death. Results suggest increasing number of L1TCs alone may not improve mortality. Alternative approaches should be sought with future regional trauma system design and implementation.

Radially oriented Ni3(HITP)2 microspheres as high-performance anode materials for Li-ion capacitors with exceptional energy density and cycling stability

Developing of high-energy, high-power-density energy storage devices is challenging. Despite being promising electrode materials for these devices, metal–organic frameworks (MOFs) have poor electrical conductivity and weak ligand–metal coordination. Here, the highly conductive MOF, Ni3(HITP)2, which comprises radially oriented microspheres, is adopted as the anode for Li-ion capacitors (LICs). The half-cell demonstrates high reversible capacity (834 mAh g−1) at 50 mA g−1 with minimal capacity reduction, attributable to the participation of C and N functional groups of the ligand and Ni2+ in the redox reactions during charge/discharge. Especially, density functional theory calculations show that, apart from the inner rings, participation of the outer rings of Ni3(HITP)2 in the redox reactions is responsible for the high Li + storage capacity. An LIC with a Ni3(HITP)2 anode and commercial activated-carbon cathode demonstrates high specific energy (120.7 Wh kg−1) at 89.2 W kg−1, nearly twice as high as that of graphite-based LICs, and maintains specific energy of 25.8 Wh kg−1 even at high specific power (7.16 kW kg−1), over the range 1–4.4 V, along with high cycling stability (76% capacity retention over 10000 cycles). The proposed radially oriented Ni3(HITP)2 microspheres have potential for application as the anode in high-performance energy storage devices.

The Challenge of Lorazepam Failure: Malignant Catatonia Treated Successfully with Valproate

IntroductionDespite the unclear nature of catatonia, the treatment response of catatonia to benzodiazepines is widely known for its typical, dramatic recovery. The neurobiological correlates of this phenomenon regarding specific receptors and neurotransmitters are unclear, as are the potential treatment options. This is important to consider when the most commonly recommended treatments of catatonia with Lorazepam or Electroconvulsive Therapy (ECT) are unavailable or unsuccessful. In this report, we describe a case of severe, malignant catatonia and psychosis mostly unresponsive to Lorazepam during two different hospitalizations, but with eventual return to baseline after successful treatment with Valproate.Objectives-To describe a unique case of malignant catatonia that was unresponsive to Lorazepam-To illustrate the potential utility of Valproate as an alternative treatment strategy for catatonia MethodsThis is a case report.ResultsA 19-year-old Hispanic male presented to our hospital initially with family reports of severe and sudden depression with bizarre behavior. Prior to this admission, the patient had been discharged recently from another tertiary hospital following a 2-week admission for severe catatonia. Chart review from that admission scored the patient’s Bush-Francis Catatonia Rating Scale (BFCRS) at 16, which remained mostly unchanged after numerous additional intramuscular doses and standing oral doses of Lorazepam, with a reduction of BFCRS the next day of only 2. During the patient’s admission at our hospital, the patient endorsed bizarre, guilt-related delusions, and his catatonia was more severe and malignant with a BFCRS of 19, with tachycardia and diaphoresis. The patient was initially given a total of seven doses of a mix of intramuscular and oral Lorazepam (total 18mg), with a minimal 2-point reduction in BFCRS. As ECT was unavailable, Lorazepam was discontinued in favor of a trial of oral Valproate 500mg twice daily, and after his catatonia subsided (with a serum level of 60.8), he was started on oral Risperidone 0.5mg once at night, titrated up to 3mg twice daily, and eventually returned to baseline as confirmed by his family members.ConclusionsThe treatment of catatonia with Lorazepam is usually reliable and has been found to be up to 80% effective, but when the recommended use of benzodiazepines and ECT fail or are unavailable, there are few studies exploring the viability of alternative treatment options. With the use of Valproate, previous studies have shown it can treat even severe catatonia (KrÜger, J Neuropsychiatry 2001; 13:303-304), or can actually be its cause (Lauterbach, Neuropsychiatry, Neuropsychology, and Behavioral Neurology. 1998 Jul;11(3):157-163). As such, this case report highlights the importance of exploring alternative treatments for catatonia, including Valproate, in order to better tailor the management of this unique syndrome.Disclosure of InterestNone Declared