Authentically, this case study shows that, proactive approach to resolve reagent input supply problems at the Process Plant of Goldfields Ghana Limited-Tarkwa Mine is the key to ensuring higher productive and competitive advantage in today’s business environment. Pragmatically, the cases studied revealed the existent to which reagent control models used at Goldfields Ghana Limited-Tarkwa Mine and pointed out the lack of advance warnings with regard to reagent inventory control chart, quality control model and lime consumption control method. Additionally, the minimum and maximum model application has limited control over inventory to meet abrupt changes in rate of usage. Clearly, the paper identifies lack of proactive measures in the area of limits set for taking corrective actions of the various models. Notably, the future warning signal of slope analysis depends on the focus of the given reference variables. Consequently, convergence of opposing focus variables depicts a deteriorating future while’s divergence point to a better future. Conversely, convergence of similar focus variables point to better future while as divergence indicates deteriorating future. The paper recommended applicable slope analysis approach as complementary methods to enhance proactive assessment of all the reagent control models to ensure the achievement of competitive advantage in the company’s endeavour. Cost and consumption variances analysis model was the further research work recommended by this paper as another method that will go a long way to enhance proactive reagent control at the Goldfields Ghana Limited-Tarkwa Mine Mineral Processing Plant operations.