Mineral Oil Treatment Research Articles

Enhanced fecal excretion of mirex in rhesus monkeys by 5% mineral oil in the diet.

The effect of two dietary treatments upon fecal excretion of Mirex was studied in rhesus monkeys dosed with 14C-Mirex. Administration of 5% mineral oil in the diet during the first month following dosing resulted in about 50% increase in fecal excretion of Mirex. The same treatment repeated 6 months after dosing triggered about a 400% increase in fecal excretion of Mirex. Subsequent dietary administration of cholestyramine resulted in a comparably small effect of fecal excretion of Mirex. The considerable difference in the ability of mineral oil to induce the effect during the first and sixth month after dosage is likely to be due to compartmental redistribution of Mirex. Mineral oil treatment appears to effect primarily the "very deep" compartment (fatty tissues) by enhancing intestinal elimination of Mirex.

Enhanced fecal elimination of stored hexachlorobenzene from rats and rhesus monkeys by hexadecane or mineral oil

The effect of various dietary treatments on the fecal excretion of [ 14C]-hexachlorobenzene (HCB) was studied in rats and rhesus monkeys. Cholestyramine and sesame oil failed to influence fecal excretion of HCB and/or metabolites. However, dietary administration of n-hexadecane (5%) increased fecal excretion of radioactivity 4–13-fold in rats and rhesus monkeys. Similarly, mineral oil in the diet (5%) of rhesus monkeys elicited a 6–9-fold increase in fecal excretion of HCB and/or metabolites. As a result of the mineral oil treatment, an enhanced depletion of HCB from blood and also of the stored HCB from adipose tissue was observed. The concentration of HCB in the blood declined in accordance with decreasing storage levels of HCB in adipose tissue. The major site of elimination of HCB and/or metabolites seemed to be the intestine; in particular, the cecum and the colon ascendens. Both hexadecane and mineral oil appeared to stimulate specifically this elimination pathway.

Enhancement and Retardation of Spontaneous Reticulum Cell Neoplasm Development in SJL/J Mice<xref ref-type="fn" rid="fn2">2</xref>

The enhancement or delay in the appearance of spontaneous reticulum cell neoplasms (RCN-B) in SJL/J mice was tested. Immunosuppressive treatment with antithymocyte serum and prolonged antigenic stimulation by repeated injections of sheep erythrocytes, leukemogenic cell-free centrifugates, and multichain synthetic polypeptides had no effect on the incidence or latency of spontaneous tumor appearance. Treatment with mineral oil or incomplete Freund adjuvant markedly enhanced tumor appearance (though the abundance of plasma cells induced by these treatments did not evoke the development of plasmacytomas, nor did it affect the incidence of serum paraproteinemia among mice with spontaneous tumors). Treatment with cortisone acetate, however, markedly retarded spontaneous tumor development. Tumors occurring early due to mineral oil and adjuvant treatment all had the characteristics of "RCN-B plasma cell type," and tumors occurring late due to cortisone treatment were all of the "RCN-B reticulum cell type." The possible involvement of the stem cell pool size in the enhancement or delay of spontaneous tumor development was discussed.

Studies on the immune responses of BALB-c mice during tumor induction by mineral oil.

AbstractThe immune responses to a number of different antigens were tested under the influence of mineral oil treatment in two strains of mice: BALB/c, which is susceptible to oncogenesis by intraperitoneal administration of oil, and C57Bl, which is resistant. A limited, but general, immunological depression was elicited by the oil treatment in the BALB/c, but not in the C57Bl, animals.Immunogenicity studies on tumors induced by mineral oil in BALB/c mice suggest that this category of neoplasms also possesses tumor‐associated antigenicity.The findings are discussed in relation to the role which may be played by dysfunction of the immune response in carcinogenic action.

An Investigation of the Mineral Oil Treatment for Corn Earworm Control12

An Investigation of the Mineral Oil Treatment for Corn Earworm Control12

Analysis of Acid Sludge from Mineral Oil Treatment

Analysis of Acid Sludge from Mineral Oil Treatment