For the purpose of evaluating the dust disaster impact scenario in the open-pit mine, a full-scale physical model of the 730E Komatsu heavy mining truck has been constructed and simulated in the ANSYS Fluent software with the refined wheel tire cannelure structure. The results show that the wind velocity poses a stationary-fluctuation-recovery sector along the longitudinal. A clockwise ellipse separation vortex shapes at the chamber hopper and two symmetrical trailing vortexes arise behind the mining truck. The dust exhibits a saddle shape distribution in the lateral section and shows a gradual sedimentation in the longitudinal, while the percentage of ultrafine dust increases from 26.5% to 46.3%. The minimum safety distance 45 m is feasible to avoid the dust disaster impact from mining truck. The dust disaster impact area presents a linear decrease along the longitudinal direction. It displays an initial increase and later decrease as the vertical height rises. The dust disaster impact scope delineation derived from the moving mining truck has a vital scientific practical significance for ensuring the personnel health security and defining the dust precise prevention priority, which contributes to improving the occupational health level in the open-pit mine.