Three-dimensional printing (3DP) technology has shown great potential in rock mechanics and mining engineering due to its ability to create complex and customized objects with high precision and accuracy. At present, an emerging research focus is improving the mechanical properties of 3D-printed samples, which originally has low strength and stiffness, to match those of natural rocks. The objective of this study was to investigate the effectiveness of different post-treatments on the strength enhancement of 3D-printed gypsum samples. To achieve this goal, 3D-printed gypsum samples were subjected to different post-treatments including dipped infiltration treatment and vacuum infiltration treatment using different infiltrants: water, saltwater, ColorBond, and StrengthMax. Subsequently, each sample was subjected to ultrasonic wave velocity testing and uniaxial compression experiments to characterize their mechanical properties, CT scans to investigate their microstructural characteristics. Additionally, X-ray Diffraction (XRD) and Scanning Electron Microscope (SEM) tests were conducted to explore the underlying reasons for changes in macroscopic strength. Finally, the physical characteristics and mechanical properties of untreated and post-processed 3D-printed gypsum samples were compared with natural rocks. The results showed that the strength of samples treated with water and saltwater was much lower than that of those treated with ColorBond and StrengthMax, while the porosity was the opposite. In water-treated and saltwater-treated samples, water or saltwater treatment can alter particle characteristics, but weak adhesive bonding and numerous pores result in low mechanical strength. Samples treated with Colorbond or StrengthMax exhibit improved strength due to effective gap filling and cohesive structure formation, with StrengthMax-treated samples showing higher strength despite having more pores than Colorbond-treated ones. Moreover, the physical and mechanical properties of these treated samples matched a wider range of natural rock types compared to the untreated samples.