Aim: The purpose of this research was to investigate the effectiveness of adolescent-oriented mindfulness training and positive psychological interventions on self-esteem and sleep problems of adolescent girls in city of Abadeh. Methods: The present research method was a post-event descriptive quasi-experimental study with control group. The statistical population of this research was all female teenagers studying in city of Abadeh, 45 of whom were selected through purposeful sampling and randomly assigned to three groups (adolescent-centered mindfulness training, positive psychological interventions, and control groups). The measurement tool was Cooper Smith's Self-Esteem Questionnaire and Pittsburgh's Sleep Quality Questionnaire. Findings: The findings showed that the relationship between pre-test and post-test in self-esteem scores and sleep problems is significant (p<0.05). Other results also showed that the main effect of the group is significant, which indicates that the main variables of the research, namely, self-esteem and sleep problems in the post-test stage, are significantly different in the two experimental and control groups (P=0.001). Conclusion: The results of multivariate and univariate covariance analysis showed that adolescent-oriented mindfulness training and positive psychological interventions increase self-esteem and reduce sleep problems in adolescent girls. Also, mindfulness intervention had a greater effect on increasing self-esteem and reducing sleep problems in adolescent girls than positive psychotherapy intervention.