Mimosa Pudica Research Articles

Antimicrobial and Membrane Stabilization Activity of Plant Extracts Against Pathogenic Bacteria and Fungi

The use and search for antimicrobial drugs derived from plants have accelerated in recent years. The present study was aimed to determine the antimicrobial, antibiofilm and membrane stabilization activities of plant extracts. Crude extracts of four plants namely, Mikania scandens (L.), Mimosa pudica (L.), Murraya paniculata (L.), and Syzygium aromaticum (L.) were tested against eleven human pathogens including four biofilm producing bacterial strains Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus, and one fungal strain Candida albicans. The antimicrobial activities as well as minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extracts were evaluated using disc diffusion and macro-broth dilution methods respectively. Among the plant extracts, ethanol extract of S. aromaticum exhibited the largest zone of inhibition 35 mm in diameter against Bacillus subtilis at 500 µg/disc concentrations. The lowest MIC (1000 µg/ml) and MBC (2500 µg/ml) were determined against P. aeruginosa with the same extract of S. aromaticum. In case of time kill assay, S. aromaticum extract showed the lowest optical density (OD600) 0.2 against E coli in 3h at MBC concentration. Moreover, the same extract of S. aromaticum displayed the strong antibiofilm activity, inhibiting 100% biofilm formation of E. coli at 2×MIC concentration. Furthermore, in vitro experiment was performed to evaluate membrane stabilization activity of plant extracts and S. aromaticum showed 100% activity in stabilizing cell membranes, preventing hemolysis of red blood cells. Therefore, this study provides valuable insight for designing antimicrobial products to efficiently eliminating human infections, and the plant extracts could be the potential antimicrobial agent. Bangladesh J Microbiol, Volume 40, Number 2, December 2023, pp 76-85

Exploring cotton SFR2’s conundrum in response to cold stress

ABSTRACT Cotton is an important agricultural crop to many regions across the globe but is sensitive to low-temperature exposure. The activity of the enzyme SENSITIVE TO FREEZING 2 (SFR2) improves cold tolerance of plants and produces trigalactosylsyldiacylglycerol (TGDG), but its role in cold sensitive plants, such as cotton remains unknown. Recently, it was reported that cotton SFR2 produced very little TGDG under normal and cold conditions. Here, we investigate cotton SFR2 activation and TGDG production. Using multiple approaches in the native system and transformation into Arabidopsis thaliana, as well as heterologous yeast expression, we provide evidence that cotton SFR2 activates differently than previously found among other plant species. We conclude with the hypothesis that SFR2 in cotton is not activated in a similar manner regarding acidification or freezing like Arabidopsis and that other regions of SFR2 protein are critical for activation of the enzyme than previously reported.

Ornamental Plant and Weed Response to Oxyfluorfen Plus Prodiamine

Ornamental plant and weed response to oxyfluorfen + prodiamine herbicide was evaluated in Connecticut and Tennessee, USA, in 2017 and 2018. Preemergence application of oxyfluorfen + prodiamine was made at 0 lb/acre, 2 + 0.75 lb/acre, 4 + 1.5 lb/acre, and 8 + 3 lb/acre to container-grown ornamental plants on an outdoor gravel pad and weeds in greenhouse experiments. Ornamental plants were treated first within a week after transplanting and again 6 weeks after the first treatment. Asiatic jasmine (Trachelospermum asiaticum), candlestick plant (Senna alata), and English ivy (Hedera helix) in Tennessee, USA; and ‘Blue Flag’ iris (Iris sp.), ‘Firecracker’ gladiolus (Gladiolus sp.), and ‘Green Carpet’ Japanese pachysandra (Pachysandra terminalis) in Connecticut, USA, were not injured with oxyfluorfen + prodiamine regardless of rate applied. Lily-of-the-Nile (Agapanthus africanus) in Tennessee, USA, and ‘Bowles’ periwinkle (Vinca minor) in Connecticut, USA, showed minor but commercially acceptable growth reduction with oxyfluorfen + prodiamine up to 4 + 1.5 lb/acre. Shasta daisy (Leucanthemum ×superbum) in Connecticut, USA, was the most sensitive ornamental plant. After the first application, average necrotic injury to Shasta daisy varied from 24% with 2 + 0.75 lb/acre to 31% with 8 + 3 lb/acre of oxyfluorfen + prodiamine. After the second application, necrotic injury was ≤ 5% with all oxyfluorfen + prodiamine rates tested and was commercially acceptable (≤ 20%). Oxyfluorfen + prodiamine reduced densities of creeping woodsorrel (Oxalis corniculata), hairy bittercress (Cardamine hirsuta), giant foxtail (Setaria faberi), and large crabgrass (Digitaria sanguinalis) ≥ 80% by 4 weeks after treatment. The fresh weed biomass 6 weeks after treatment indicated an 88% to 99% reduction compared with the untreated control.

In vitro Acaricidal Activity of Serratia Ureilytica Against the Dust Mite Tyrophagus Putrescentiae and Identification of Genes Related to Biocontrol.

The present study evaluated the acaricidal activity of three Serratia strains isolated from Mimosa pudica nodules in the Lancandon zone Chiapas, Mexico. The analysis of the genomes based on the Average Nucleotide Identity, the phylogenetic relationships allows the isolates to be placed in the Serria ureilytica clade. The size of the genomes of the three strains is 5.4Mb, with a GC content of 59%. The Serratia UTS2 strain presented the highest mortality with 61.41% against Tyrophagus putrescentiae followed by the Serratia UTS4 strain with 52.66% and Serratia UTS3 with 47.69% at 72h at a concentration of 1X109 cell/mL. In the bioinformatic analysis of the genomes, genes related to the synthesis of chitinases, proteases and cellulases were identified, which have been reported for the biocontrol of mites. It is the first report of S. ureilytica with acaricidal activity, which may be an alternative for the biocontrol of stored products with high fat and protein content.

A Review Article on the Formulation and Evaluation of Herbal Hair Oil

The excellent activity of herbal formulations and their little or nonexistent adverse effects as compared to synthetic medications have always drawn a lot of attention. This study's objective is to make herbal hair oil using amla, hibiscus, Brahmi, and methi. and it will be assessed to see if it promotes healthy hair development, the oil of different concentrations was water soluble, water insoluble, sulphated, total ash, acid insoluble, and moisture content are among the characteristics that make it suitable for proximate analysis. Excellent outcomes for hair development were observed in the formulation made using the boiling method for preparing oils. In order to achieve this goal, the current study will prepare herbal hair oil using substances such as Amlawhich is known as Jatamansi or hibiscus Bhringraj Raw garlic includes methi, mimosa pudica handspringing, papaya leaves, curry-leaf Moringa, guava leaves, and muskmelon seeds.. Based on the aforementioned findings, a combination of unrefined medications was made by boiling and then formed into herbal hair oil. Using various herbal drugs, we have created five different formulas, all of which exhibit anti-hair fall properties along with additional beneficial effects like reducing hair pigmentation, improving the flow of blood to the forehead and roots, reducing dandruff, and reducing hair whitening.

Potential of Mango Leaf Methanol Extract (Mangifera indica L.) as A Bioherbicide Against The Growth of Putri Malu Weed (Mimosa pudica L.)

Putri Malu (Mimosa pudica L.) is a weed that often found in various places, especially on agricultural land and plantations. Mangifera indica L. has potential as a bioherbicide because it contains aleochemical compounds, which inhibit the growth of other plants. This research aims to determine the potential and the best concentration of methanol extract of mango leaves (Mangifera indica L.) in inhibiting the growth of putrimalu weed (Mimosa pudica L.). This research was carried out for four months, in the Kasa House Laboratory, Biology Department, Faculty of Mathematics and Natural Sciences, Tanjungpura University. The research used a Completely Randomized Design (CRD) with five mango leaf extract concentration treatment levels, namely control (P0), 10% (P1), 20% (P2), 30% (P3), and 40% (P4). Each treatment was repeated five times to obtain 25 experimental units. The results showed that the methanol extract of mango leaves (Mangifera indica L.) had an effect on inhibiting the germination and growth of the M. pudica weed. The best concentration of methanol extract of mango leaves in inhibiting the germination and growth of putrimalu weed is a concentration of 20%.

Plants Used in Traditional Medicine by some Tribals of Jalpaiguri District, West Bengal

The paper deals with 30 selected species of plants e.g. Costus speciosus (Keen.) Sm., Drynaria quercifolia (L.) J. Sm., Melastoma malabathricum L., Mimosa pudica L., Pedilanthus tithymaloides (L.) Poit., Premna latifolia Roxb., Solanum viarum Dunal, Thelypteris arida (D. Don) Morton, etc. which are used as medicine by some of the tribals like Mech, Rabha and Oraon of the Jalpaiguri District of West Bengal in their traditional system of treatment.Ethnobotanical field study reveals some interesting information about mode of their uses of plants in various ailments either single or in combination with other plant parts. It has been observed that though these tribes are living under same environment and using the same species of plants for curing disease, their Prescriptions are quite different. This indicates that the tribes are still retaining their own tradition so far as treatments are concerned.

Preparation and Evaluation of Herbal Oil

Herbal formulations always have lesser or no side effects comparatively with synthetic. The aim of present study involves preparation of herbal hair oil using the herbal ingredients like., Amla, Hibiscus, Bhringraj, Jatamansi, Raw garlic, Muskmelon seeds, Moringa, Curry leaves, Guava leaves, Papaya leaves, Methi, Mimosa Pudica and Spring onion. Based on the above observations, mixture of crude drugs was prepared in the form of herbal hair oil by boiling method. We have used five formulas using different herbal drugs and all the formulation are showing anti-hairfall property with someof other beneficial activities like anti-dandruff activity, improves blood circulation to the scalp and roots, reduce hair pigmentation, anti-fungal activity, reducing the whitening of the hair. The formulate dherbal oil was evaluated by using various parameters such as Organoleptic properties, specific gravity, stability, viscosity, Acid value, pH etc. and the value obtained from it are found to be similar to that of the standard values like there is no sedimentation, no grittiness and shows satisfying organoleptic properties and the results were determined and are reported in this work. The goal of the present study is herbal have the effective formulation for the hair care or in hair treatment

Influence of transplanting date and integrated weed management in system of rice intensification of aromatic black rice (Oryza sativa)

A field experiment was conducted during rainy seasons (kharif) of 2019 and 2020 at the research farm of School of Agricultural Sciences, Nagaland University, Nagaland to study the effect of transplanting date and weed management practices on productivity and profitability of aromatic black rice (Oryza sativa L.) under system of rice intensification. The experiment was conducted in a split plot design (SPD) with 3 transplanting dates (D1, 15th June; D2, 30th June; and D3, 15th July) in main plot and 5 weed managements practices [W1, Weedy check; W2, Conoweeding at 20 and 40 DAT (days after transplanting); W3, Pretilachlor @0.75 kg/ha (PE) fb hand weeding (HW) at 40 DAT; W4, Pretilachlor @0.75 kg/ha (PE) fb conoweeder at 40 DAT; and W5, Pretilachlor at 0.75 kg/ha (PE) fb bispyribac-sodium @ 25 g/ha (PoE)] in sub-plot, replicated thrice. Results showed that the most abundant weed flora observed in the experimental field were Fimbristylis quinquangularis (Vahl) Kunth, Cyperus esculentus (L.), Cyperus iria (L.), Rhynchospora colorata (L.) H.Pfeiff., Ludwigia linifolia Poir, Mimosa pudica (L.), Mimosa diplotricha Sauvalle, Scoparia dulcis (L.) and Eriochloa villosa (Thunb.) Kunth. Transplanting on 15th June recorded highest growth and yield of black rice. The improvement in the grain yield was about 39% under 15th June over 15th July transplanting date. Among weed management practices, pretilachlor @0.75 kg/ha at 3 DAT fb HW at 40 DAT recorded minimum density of weeds resulting in higher growth attributes and yield of black rice. Economic analysis showed that highest benefit cost (B:C) ratio was obtained when black rice was transplanted on 15th June along with application of pretilachlor @0.75 kg/ha at 3 DAT fb bispyribac-sodium @25 g/ha at 20 DAT and demonstrated to be the best treatment for profitable production of black rice under system of rice intensification.

Phytochemical Study, Evaluation of Antihelminthic Potential and In silico Screening for Breast Cancer Using Mimosa pudica Linn.

Breast Cancer is a major health concern in India, where it is highly lethal for women because of unchecked cell proliferation and metastasis, which are frequently caused by interactions between the Estrogen Receptor Alpha and other receptors. Even though they work well, synthetic Anthelmintics come with dangers to the health of both humans and animals. Therefore, creating effective and safe Anthelmintics from plant sources is our main goal. We extracted Mimosa pudica leaves with ethanol using a Soxhlet system, and after concentration, we examined the extract using GC-MS, FTIR, and UV techniques. Estrogen Receptor structure and flavonoid compound databases from PubChem and Protein Data Bank were used for in silico testing against Breast Cancer and anthelmintic action, respectively. Using molecular docking and drug similarity investigations, the effectiveness of natural compounds against Breast Cancer was evaluated.

Detect urban trees air pollution sensitivity & tolerance by leaf trait analysis in the industrial zone of Kumaun Himalaya Uttarakhand India

The plant absorbs gases and particulate matter through its leaves and contributes to cleaning the atmospheric pollutants. Sensitive plant species act as bioindicators of air pollution, while tolerant species are sinks of air pollutants. However, in ecologically sensitive regions like the Himalayas, there are no guiding rules for the selection of roadside plants for urban development due to a lack of scientific research. To address this, this study aimed to identify roadside plant species sensitivity and tolerance to air pollution near the industrial hub Rudrapur located in Kumaun Himalaya using the Air Pollution Tolerance Index (APTI). The APTI is used as a tool for evaluating and categorizing plants according to their levels of tolerance or sensitivity to air pollutants. In this study, the APTI of five plant species has been measured. A One-Way ANOVA was conducted to assess variations in biochemical parameters of five chosen roadside plant species situated at two distinct sites. Mangifera indica and Nerium species were recorded with high APTI values, indicating their tolerance to air pollution. However, the Eucalyptus species was identified as the most sensitive species with low APTI. Selecting suitable tree species to combat air pollution can improve the urban environment.

Mimosa pudica L. extract ameliorates pulmonary fibrosis via modulation of MAPK signaling pathways and FOXO3 stabilization

Ethnopharmacological relevanceIdiopathic pulmonary fibrosis (IPF) is a progressive fibrosing pulmonary disorder that has a poor prognosis and high mortality. Although there has been extensive effort to introduce several new anti-fibrotic agents in the past decade, IPF remains an incurable disease. Mimosa pudica L., an indigenous Vietnamese plant, has been empirically used to treat respiratory disorders. Nevertheless, the therapeutic effects of M. pudica (MP) on lung fibrosis and the mechanisms underlying those effects remain unclear. Aim of the studyThis study investigated the protective effect of a crude ethanol extract of the above-ground parts of MP against pulmonary fibrogenesis. Materials and methodsInflammatory responses triggered by TNFα in structural lung cells were examined in normal human lung fibroblasts and A549 alveolar epithelial cells using Western blot analysis, reverse transcription–quantitative polymerase chain reaction assays, and immunocytochemistry. The epithelial-to-mesenchymal transition (EMT) was examined via cell morphology observations, F-actin fluorescent staining, gene and protein expression measurements, and a wound-healing assay. Anti-fibrotic assays including collagen release, differentiation, and measurements of fibrosis-related gene and protein expression levels were performed on TGFβ-stimulated human lung fibroblasts and lung fibroblasts derived from mice with fibrotic lungs. Finally, in vitro anti-fibrotic activities were validated using a mouse model of bleomycin-induced pulmonary fibrosis. ResultsMP alleviated the inflammatory responses of A549 alveolar epithelial cells and lung fibroblasts, as revealed by inhibition of TNFα-induced chemotactic cytokine and chemokine expression, along with inactivation of the MAPK and NFκB signalling pathways. MP also partially reversed the TGFβ-promoted EMT via downregulation of mesenchymal markers in A549 cells. Importantly, MP decreased the expression levels of fibrosis-related genes/proteins including collagen I, fibronectin, and αSMA; moreover, it suppressed collagen secretion and prevented myofibroblast differentiation in lung fibroblasts. These effects were mediated by FOXO3 stabilization through suppression of TGFβ-induced ERK1/2 phosphorylation. MP consistently protected mice from the onset and progression of bleomycin-induced pulmonary fibrosis. ConclusionThis study explored the multifaceted roles of MP in counteracting the pathobiological processes of lung fibrosis. The results suggest that further evaluation of MP could yield candidate therapies for IPF.

Distribution and Conservation Status of Plants’ species in the Botanical Garden and Arboretum domiciled in University of Uyo, Nigeria

This research assessed the plant species composition, distribution and International Union for the Conservation of Nature (IUCN) conservation status of plants in University of Uyo botanical garden and arboretum using systematic sampling technique. The species were sampled in 10 x 10 m quadrats spaced at least regular intervals of 20 m from each quadrat. Thirty-one and thirty-eight species were encountered in the arboretum and botanic garden respectively. In terms of the frequency, Chromolaena odorata and Nauclea diderichii had the highest values (75%), while Acanthus montanus, Anthocleista djalonensis, Anthonotha macrophylla, Baphia nitida, Barteria nigritiana, Carpolobia lutea, Ceiba pentandra, Cnestis ferruginea, Entandrophragma utile, Hura crepitans, Lonchocarpus griffoneonus, Rauvolfia vomitoria, Senna siamea, Tamarindus indica, Tectona grandis and Treculia africana had the least frequency (25% each). For the density, Nauclea diderichii had the value of 250±15.30 st/ha. In the botanic garden, Ageratum houstonianum, Alchornea cordifolia, Chromolaena ordorata and Croton hirtus had the highest frequency (100%) while Allamanda cathartica, Asystasia gangetica, Bambusa vulgaris, Caladium bicolor, Centrosema virginianum, Cnestis ferruginea, Culcasia scandens, Cyathula prostrata, Desmodium scorpiurus, Emilia sonchifolia, Heliconia psittacorum, Ipomea involucrata, Lagenaria sphaerica, Mimosa pudica, Nephrolepis bisserata, Panicum sp., Pentaclethra macrophylla, Plumeria rubra, Polyalthia longifolia, Pteridium aquilinum, Scoparia dulcis, Senna siamea, Sesamum radiatum and Sida acuta had the least frequency (33.33%). The vegetation of both sites indicated variation in composition of trees, shrubs, herbs, climbers and ferns. These heterogeneities may be a pointer to their varying adaptation levels and differential responses of plant species to pedological and anthropogenic influences.

Mechanism of the Pulvinus-Driven Leaf Movement: An Overview.

Leaf movement is a manifestation of plant response to the changing internal and external environment, aiming to optimize plant growth and development. Leaf movement is usually driven by a specialized motor organ, the pulvinus, and this movement is associated with different changes in volume and expansion on the two sides of the pulvinus. Blue light, auxin, GA, H+-ATPase, K+, Cl-, Ca2+, actin, and aquaporin collectively influence the changes in water flux in the tissue of the extensor and flexor of the pulvinus to establish a turgor pressure difference, thereby controlling leaf movement. However, how these factors regulate the multicellular motility of the pulvinus tissues in a species remains obscure. In addition, model plants such as Medicago truncatula, Mimosa pudica, and Samanea saman have been used to study pulvinus-driven leaf movement, showing a similarity in their pulvinus movement mechanisms. In this review, we summarize past research findings from the three model plants, and using Medicago truncatula as an example, suggest that genes regulating pulvinus movement are also involved in regulating plant growth and development. We also propose a model in which the variation of ion flux and water flux are critical steps to pulvinus movement and highlight questions for future research.

Development and evaluation of a pH-responsive Mimosa pudica seed mucilage/β- cyclodextrin-co-poly(methacrylate) hydrogel for controlled drug delivery: In vitro and in vivo assessment

In this comprehensive investigation, a novel pH-responsive hydrogel system comprising mimosa seed mucilage (MSM), β-cyclodextrin (β-CD), and methacrylic acid (MAA) was developed via free radical polymerization technique to promote controlled drug delivery. The hydrogel synthesis involved strategic variations in polymer, monomer, and crosslinker content in fine-tuning its drug-release properties. The resultant hydrogel exhibited remarkable pH sensitivity, selectively liberating the model drug (Capecitabine = CAP) under basic conditions while significantly reducing release in an acidic environment. Morphological, thermal, and structural analyses proved that CAP has a porous texture, high stability, and an amorphous nature. In vitro drug release experiments showcased a sustained and controlled release profile. Optimum release (85.33 %) results were recorded over 24 h at pH 7.4 in the case of MMB9. Pharmacokinetic evaluation in healthy male rabbits confirmed bioavailability enhancement and sustained release capabilities. Furthermore, rigorous toxicity evaluations and histopathological analyses ensured the safety and biocompatibility of the hydrogel. This pH-triggered drug delivery system can be a promising carrier system for drugs involving frequent administrations.

Sustainable characterization of brake pads using raw/silane‐treated Mimosa pudica fibers for automobile applications

AbstractThe demand for bio‐fiber composites has increased globally due to the environmental impact of non‐sustainable materials. In this context, Natural fibers are becoming increasingly popular in various applications due to their sustainability. This study explores silane‐treated Mimosa pudica (MP) fibers obtained from the relevant plant that were treated with silane and utilized to strengthen composites used in brake friction development. Five different formulations for brake friction composites were developed using silane‐treated and untreated MP fibers combined with inert filler synthetic barites and maintaining other ingredients in constant amounts. The brake pads were then evaluated for physical, chemical, mechanical, and thermal properties, and their tribological performance was assessed using the chase test, following SAE J661‐2021. The test results revealed that the silane‐treated fibers had a higher cellulose content of 57.2%, while the untreated fibers had a cellulose content of 48.7%. The Rockwell hardness‐K scale value was higher for brake pads made with 5 wt% silane‐treated fibers, with a value of 95. The wear loss was lower for brake pads made with 10 wt% silane‐treated MP fibers‐based brake pads than other composites. Scanning Electron Microscope analyzed the worn surface features of the brake pads used in the Chase test.Highlights Mimosa pudica fibers were utilized as reinforcement in brake pads Silane‐treated Mimosa pudica fibers showed higher cellulose content and improved thermal stability Silane‐treated Mimosa pudica fibers‐based brake pads showed optimal μ and lower wear rate.

Transcriptomic and metabolomic profiling provide insight into the role of sugars and hormones in leaf senescence of Pinellia ternata.

The interaction network and pathway map uncover the potential crosstalk between sugar and hormone metabolisms as a possible reason for leaf senescence in P. ternata. Pinellia ternata, an environmentally sensitive medicinal plant, undergoes leaf senescence twice a year, affecting its development and yield. Understanding the potential mechanism that delays leaf senescence could theoretically decrease yield losses. In this study, a typical senescent population model was constructed, and an integrated analysis of transcriptomic and metabolomic profiles of P. ternata was conducted using two early leaf senescence populations and two stay-green populations. The result showed that two key gene modules were associated with leaf senescence which were mainly enriched in sugar and hormone signaling pathways, respectively. A network constructed by unigenes and metabolisms related to the obtained two pathways revealed that several compounds such as D-arabitol and 2MeScZR have a higher significance ranking. In addition, a total of 130 hub genes in this network were categorized into 3 classes based on connectivity. Among them, 34 hub genes were further analyzed through a pathway map, the potential crosstalk between sugar and hormone metabolisms might be an underlying reason of leaf senescence in P. ternata. These findings address the knowledge gap regarding leaf senescence in P. ternata, providing candidate germplasms for molecular breeding and laying theoretical basis for the realization of finely regulated cultivation in future.

Unveiling Makahiya Plant (Mimosa Pudica) Tea: A Natural Approach to Easing Dysmenorrhea Discomfort through Natural Process of Flouration

Dysmenorrhea, or painful menstrual cramps, is one of the most frequent gynecological illnesses. Several factors influence the expression of this biological event, including diet, lifestyle, cultural expectations and behaviors, and individual constitutions (Omani Samani et al., 2018). Mimosa Pudica is commonly utilized to treat dysmenorrhea and is often made via decoction, according to ethnobotanical research (Magtalas M. et al, 2023). The present study used phytochemical analysis to pinpoint vital compounds in Mimosa Pudica that aid in alleviating dysmenorrhea discomfort. The researchers also interviewed 15 participants who consume Mimosa Pudica tea during their menstrual cycle. The phytochemical analysis of Makahiya (Mimosa Pudica) has unveiled steroids, flavonoids, saponins, and tannins. These substances discovered through phytochemical analysis suggest that Makahiya (Mimosa Pudica) has therapeutic properties and can be used in easing dysmenorrhea. The researchers conclude that Mimosa Pudica tea can be used as an alternative treatment for dysmenorrhea providing more options to women who are suffering from this issue.

Evaluation of Antidiabetic Activity and Cytotoxic Effect of Strontium Nanoparticles Synthesized Using Mimosa Pudica.

Nanotechnology is emerging as a promising approach in the development of novel therapeutic strategies. Nanoparticles, due to their unique physicochemical properties and small size, have the potential to improve the delivery of therapeutic agents, enhance their bioavailability, and increase their efficacy. Among various types of nanoparticles, strontium nanoparticles have gained attention due to their potential antidiabetic activity and cytotoxic effects against cancer cells. Mimosa pudica, also known as "Sensitive Plant" or "Touch-Me-Not," is a medicinal plant known for its diverse pharmacological activities, including antidiabetic and anticancer properties. Recent research has focused on the synthesis of strontium nanoparticles by using Mimosa pudica as a green and sustainable approach. These nanoparticles have shown promising results in terms of their antidiabetic activity and cytotoxic effects against cancer cells. Thus, in this study, the antidiabetic effect was studied using the alpha-amylase inhibitor assay, and the cytotoxic effect was studied using the brine shrimp lethality assay. In these assays, increasing concentration of Mimosa pudica-mediated strontium nanoparticles exhibited increasing antidiabetic and cytotoxic effects, which was similar to the standard used, which is acarbose. Hence, this can be used as a novel antidiabetic and cytotoxic agent in the future.

Green Synthesis of Mimosa pudica-Mediated Strontium Nanoparticles and its Anti-Inflammatory Activity.

Considerable focus has been directed toward green synthesis as a dependable, sustainable, and environmentally friendly approach for synthesizing various nanomaterials. Mimosa pudica, a quickly grown pantropical weed, has been used widely for its anti-inflammatory and antimicrobial activity in traditional medicine. The development of strontium-based nanoparticles and nanoparticles linked with strontium has garnered attention in recent years due to their established utility in diverse domains such as effective drug distribution, bioimaging, cancer treatment, and advancements in bone engineering. To examine the green synthesise of strontium nanoparticles using Mimosa pudica and its anti-inflammatory activity. Mimosa pudica-mediated strontium nanoparticles' anti-inflammatory activity was tested using bovine serum albumin denaturation assay, egg albumin denaturation assay, and membrane stabilization assay with diclofenac sodium as the standard. Result: In all three assays, increasing concentration of Mimosa pudica-mediated strontium nanoparticles exhibited an increasing anti-inflammatory effect, which was similar to the standard diclofenac sodium. Consequently, this holds promise as a new potential anti-inflammatory agent in forthcoming applications.