A novel variable enhanced late intake valve closing (LIVC) Miller cycle with asynchronous valve opening was proposed. Relevant tests were carried out in a supercharged spark ignition (SI) engine with high compression ratio, which mainly included the effects of variable valve timing on performance and combustion characteristics, as well as the comparison with the baseline engine. The purpose of this study was to explore the effect of different intake and exhaust opening timing on the performance and combustion characteristics of the enhanced LIVC Miller cycle with asynchronous valve opening, and further explore the energy saving potential of this Miller cycle. The results showed that the application of variable enhanced Miller cycle effectively improved the anti-knock ability and pumping loss of the engine with high compression ratio. On the one hand, the optimization of pumping loss substantially improved the fuel economy under small load conditions. On the other hand, better combustion performance and air-fuel ratio could be achieved at medium and high loads. Meanwhile, the exhaust valve should be opened as earlier as possible to achieve the best fuel economy. Correspondingly, under optimal valve timing, compared with the baseline engine, the asynchronous intake valve opening variable enhanced Miller cycle engine with high compression ratio had a fuel economy optimization of more than 3.5 % under all loads, and the maximum fuel economy optimization was 12.74 % under the condition of 11 bar.