Infant formulae are designed to meet all the nutritional needs of the human neonate. The mineral composition of infant formulae is based primarily on the mineral content of human milk as well as on intra-uterine accretion. There are instances, however, when the mineral concentrations of infant formulae are set higher to address a deficiency such as iron deficiency anemia. Additionally, rapid growth of premature infants necessitate formulae of higher mineral content including trace elements such as zinc and copper and macrominerals such as calcium and phosphorus. A number of factors affect mineral utilization: mineral solubility, mineral–mineral interactions and macronutrient–mineral interactions. All of the above are important considerations when designing an infant formula.