The 2022 Annual Meeting of the Congress of Neurological Surgeons was held in San Francisco, CA, from October 8-12, 2022. Volume 69 of Clinical Neurosurgery represents the official compilation of the 2022 CNS Annual Meeting. This volume highlights invited scientific manuscripts from the plenary sessions and the 2022 CNS Presidential Address from Dr Nicholas C. Bambakidis. In addition, you will find bibliographic information on the 2022 Honored Guest, Dr Robert F. Spetzler. The annual meeting leadership team included Dr Ashok R. Asthagiri, Annual Meeting Chair; Dr Lola B. Chambless, Scientific Program Chair; and Dr Garni Barkhoudarian, Vice Scientific Program Chair. This year's meeting, themed “Neurosurgery Connected,” was embodied by the spirit of its participants. After years of meeting cancellations and/or limitations, this meeting was highly attended and had a record number of abstract submissions. International attendance additionally increased, and members from around the world were greeted and welcomed at a special reception. The CNS was thrilled to partner with The Japanese Congress of Neurological Surgeons, Neurological Society of India, and the Brazilian Society of Neurosurgery. The scientific and lectureship content of this year's annual meeting were as diverse as they were connecting. We heard from the likes of military pilot, Vernice “FlyGirl” Armour, actor William Shatner, and athletes, Carl Lewis and Dee Caffari, all touching on themes of connectivity, creativity, perseverance, and leadership. All speakers had seen and explored new frontiers, many being the first of their kind to achieve such feats. Dr Warren R. Selman opened the meeting by addressing our connections to each other and trainees through mentorship. Honored guest, Dr Robert F. Spetzler, shared his vast experience in vascular neurosurgery, and his trainees from all over the world expressed their gratitude having learned from his wisdom. Not to mention, the countless podium talks, seminars, symposia, and sessions. New sessions in data science and medical education featured speakers from multiple disciplines including neurosurgeons and those working in the fields of technology. A lunch symposium focused on diversity addressed the “Changing Face of Neurosurgery,” and students from the CNS Foundation Pathways Program were welcomed to the meeting to learn about our field. This meeting embodied what it means for us to be connected as a neurosurgical community. It has been a pleasure and honor to serve as Editor of Clinical Neurosurgery this past year. I would like to thank the Congress of Neurological Surgeons staff and the staff at Neurosurgery Publications, particularly Caitlyn Trautwein, Journal Editor. I would like to extend a special thank you to Dr Douglas Kondziolka, Editor-in-Chief, Neurosurgery Publications, for all his support and dedication to this volume. I welcome Dr Alexander A. Khalessi as the new President of the Congress of Neurological Surgeons and look forward to seeing you all in Washington, DC, in 2023.