Preterm labor remains one of the most important problems in obstetrics and a common public health problem. It should be noted, that a large group of diseases associated with the development of prematurity are endocrine disorders and the share of various forms of endocrine disorders in pregnancy is increasing. Research objective: to study the structure and frequency of endocrine disorders in women with preterm labor. Materials and methods. A retrospective study was conducted to study the structure and frequency of endocrine disorders in 2,426 women with preterm labor. The frequency of endocrine disorders assessed, such as hyperandrogenism (polycystic ovary syndrome(PCOS), non-classic сongenital adrenal hyperplasia (CAH), Cushing’s syndrome), thyroid disorders (hypothyroidism, autoimmune thyroid disease, hyperthyroidism), hyperprolactinemia, diabetes mellitus, including gestational diabetes mellitus; hyperparathyroidism. Results. The study showed that endocrine disorders were observed in 37% of women with preterm labor (898 women out of 2,426 women with preterm labor). In particular, 364 (15%) women with preterm labor had diabetes mellitus, including gestational diabetes mellitus, 339 (13,8%) - PCOS, 170 (7%) - non-classic congenital adrenal hyperplasia (CAH), 3 (0.12%) - Cushing's syndrome. Hyperprolactinaemia was observed in 267 (11%) women with preterm labor, and hyperparathyroidism - in 2 (0.08%) women with preterm labor. Thyroid disorders occurred in 582 (23,9%) women with preterm labor. Among women with preterm labor and thyroid disorders, the largest group was women with mild thyroid dysfunction, such as subclinical hypothyroidism, isolated hypothyroxinemia, or TPOAb positivity - 379 (65%) women out of 582 women with thyroid disorders. It is significant, that women with preterm labor most often had uncontrolled endocrine disorders, whether poorly controlled pre-conception or first diagnosed during pregnancy - 503 (56%) women out of 898 women with ED. Conclusions. The high frequency of endocrine disorders among women with preterm labor (37%), revealed in our study, indicates that today endocrine disorders remain an important factor in preterm labor. In addition, results of our study showed, that among women with preterm labor and thyroid disorders, the largest group was women with mild thyroid dysfunction. It also implies that it is important to actively plan to assess early gestational thyroid function tests in women known to have thyroid disorders preconception. It is significant, that women with preterm labor most often had uncontrolled endocrine disorders, whether poorly controlled pre-conception or first diagnosed during pregnancy. This should be considered when developing a strategy for the prevention of preterm labor and planning a pregnancy in women with endocrine disorders.