Mild Acne Vulgaris Research Articles

THE INFLUENCES OF KNOWLEDGE LEVEL BEHAVIOUR AND ATTITUDE IN SELECTING TYPE OF POWDER ON THE INCIDENCE OF ACNE VULGARIS IN BANYUMAS REGENCY

Background: Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Pathogenesis of Acne vulgaris is estimated to be related to several triggering factors such as food by 23.2%, stress by 26.4%, hormones by 32.7% and use of cosmetics by 47.3%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. In the content of powder that causes acne vulgaris because there are comedogenic ingredients such as lanolin. Methods: This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. Results: The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). Conclusion: the level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.

Calprotectin may be positively associated with the severity of acne vulgaris

Background and objective: Acne vulgaris (AV) is a common skin disease of sebaceous hair follicles. Many factors are associated with the occurrence and severity of acne, while the exact etiology remains incompletely understood. The current study was aimed to investigate the association between the severity of acne and serum zinc, copper, and calprotectin. Methods: Fifty patients with AV were recruited in the study as well as 25 healthy age and sex-matched individuals as controls. The acne severity was classified into mild (n=21), moderate (n=16), and severe acne (n=14) according to the global acne grading system (GAGS). Serum levels of zinc, acne and calprotectin were evaluated by enzyme-linked immunosorbent assay (ELISA). The gained data were analyzed using GraphPad Prism software. Results: Insignificant difference was found in zinc and copper levels between controls and AV patients, except in severe AV, where the patients displayed significant elevation in serum copper level (p<0.05) as compared to that of mild AV. The calprotectin concentration was significantly higher (p<0.001) in all AV patients, when compared with healthy subjects, which was positively correlated with the disease severity. No gender difference was noted for all measured biomarkers. Conclusions: Our study suggests a possible association between calprotectin and acne inflammation, which requires validation in large-scale studies.

New Normal Mask-Wearing and Its Impact on Underneath Skin Microbiome: A Cross-Sectional Study in Mild Acne Vulgaris Patients

Introduction: Prolonged mask-wearing could modulate the skin microenvironment resulting in several facial dermatoses. Microbial dysbiosis is proposed to be linked with these changes; however, data regarding the association is still limited. Accordingly, we aimed to explore the impact of face masks on the skin’s bacterial microbiota. Methods: We classified participants into short (<4 h/day) and long (≥4 h/day) mask-wearing time (SMWT and LMWT) groups according to mask-wearing time per day in the previous 2 weeks. Specimens were swabbed from the cheek and forehead of 45 mild acne vulgaris patients, representing mask-covered area (MCA) and mask-uncovered area (MUA), respectively. The 16S rRNA gene sequencing and QIIME2 were used to characterize bacterial communities. Results: There were 12 (26.7%) and 33 (73.3%) participants in SMWT and LMWT, respectively. There were no significant differences in beta diversity across MCA/MUA or LMWT/SMWT groups. In alpha-diversity, the evenness on MCA was significantly lower in LMWT than in SMWT (p value = 0.049). Among all groups, the relative abundance of bacterial taxa was similar, showing Actinobacteriota and Firmicutes, and Cutibacterium and Staphylococcus as the most predominant phyla and genera, respectively. Conclusion: Our results showed no significant impact of mask-wearing on the skin microbiota in mild acne vulgaris participants.

Plasma malondialdehyde levels related to acne vulgaris severity

Background: Acne vulgaris (AV) is a multifactorial disorder characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. Oxidative stress plays a role in the pathogenesis of AV. Reactive Oxygen Species (ROS), especially lipid peroxides (LPO), plays a role in mediating acne inflammation. Malondialdehyde (MDA) is one of the byproducts of LPO commonly used as a biomarker of cell damage. Methods: This cross-sectional analytic study consisted of sixty patients with AV . The samples were taken from the blood plasma of AV subjects. An enzyme-linked immunosorbent assay (ELISA) examination was performed. The normality of data distribution was determined using the Kolmogorov-Smirnov test and the differences of plasma MDA levels based on the severity of AV were determined using the Kruskal-Wallis test. P value&lt;0,001 was considered significant. Results: Acne vulgaris was predominantly found in women (70%), age group of 18 &ndash; 25 years old (73,33%), and patients with family history of AV (61,67%). Higher plasma MDA levels were found in women [5,5 (2,53 &ndash; 77,6) nmol/mL], age group of 26 &ndash; 35 years [5,66 (2,73 &ndash; 25) nmol/mL], and subjects with family history of AV [5,49 (2,53 &ndash; 77,6) nmol/mL]. Based on the severity of AV, the severe AV group had highest plasma MDA [ 13,85 (2,69 &ndash; 77,6) nmol/mL], followed by moderate AV group [ 4,46 (2,53-14,3) nmol/mL] and mild AV [ 3,78 (2,47-6,88) nmol/mL]. There were differences in plasma MDA level based on the severity of AV (p&lt;0,001). Conclusion: There were differences in plasma MDA levels based on the severity of AV. &nbsp; Keywords: acne vulgaris, malondialdehyde, severity

ASSOCIATION BETWEEN MAGNESIUM LEVELS AND THE SEVERITY OF ACNE VULGARIS

Introduction: Acne vulgaris is a cosmetic problem that often occurs in 80% of the population, especially reproductive age (12-25 years). Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles with multifactorial causes and clinical manifestations of blackheads, papules, pustules, nodules, and cysts. Magnesium plays a role in increasing skin hydration, increasing skin permeability, barrier repair, and facilitating skin proliferation and epidermal differentiation to reduce inflammation. Hypomagnesium is thought to increase inflammation and affect androgen hormones, especially testosterone, which plays a role in increasing the hyperactivity of the sebaceous glands in the pathogenesis of Acne Vulgaris. Purpose: To determine the difference in magnesium levels in each severity degree of acne vulgaris, namely mild, moderate, and severe. Method: This study is an analytic observational study with a cross-sectional design. The sampling technique is purposive sampling with a total sample of 30 people. Data retrieval in this study was carried out using photo taking of three sides of the face (front, right oblique, left oblique). Then proceed with a three cc venous blood draw to measure magnesium levels in the blood. Results: This study found a significant difference between magnesium levels and the severity of acne vulgaris with a value of p = 0.032 (p &lt;0.05). Magnesium levels in severe acne vulgaris were higher than moderate and mild acne vulgaris. However, magnesium levels in all samples were still within the normal range. There was a moderate positive correlation between the two variables with a p-value = 0.016 (p &lt;0.05). Conclusion: There was a significant difference between magnesium levels and the severity of acne vulgaris, and there is a moderate positive correlation between magnesium levels and the severity of acne vulgaris, which means that the higher the magnesium level, the more severe the degree of acne vulgaris.

Association between serum level of desnutrin and acne vulgaris

Objectives To assess the association between serum levels of desnutrin enzyme and the development of acne vulgaris. Background Acne vulgaris is commonly associated with hyperglycemia, which probably results in serum desnutrin suppression and abolishment of its function. Patients and methods A case–control study was conducted on 30 patients with acne vulgaris (group I) and 10 age-matched, sex-matched, and BMI-matched healthy volunteers who had no present and past history of acne as controls (group II). In all, blood glucose, serum total cholesterol, serum triglycerides, and serum desnutrin were assessed. According to severity, patients were divided into three subgroups: group Ia included 10 patients with mild acne vulgaris, group Ib included 10 patients with moderate activity, and group Ic included 10 patients with severe activity. Results There was a significant statistical decrease in serum desnutrin level in patients with acne (41.56±9.35) than controls (208.38±61.87), with P value less than 0.001. Moreover, there was a significant statistical increase in fasting blood glucose level in acne patients (88.71±4.26) than controls (83.28±4.61), with P value=0.001. There was a nonsignificant positive correlation between serum desnutrin and each of acne severity and fasting blood glucose. Conclusion Serum desnutrin levels were significantly decreased in patients with acne vulgaris but were not correlated with acne severity and not affected by sex.

Morphological and biochemical evaluation of blood in young women with common acne – preliminary report

Introduction: Acne is one of the most common skin diseases, defined as a chronic, inflammatory disease of the sebaceous gland and hair follicle. It is most common in young people, although the lesions may persist even up to 30 – 40 years of age. It is characterized clinically by the presence of non-inflammatory and inflammatory eruptions (papules and pustules) and usually with increased production of sebum. The reasons for the appearance of acne include hormonal disorders, obesity, stress, diet, environmental and genetic factors, cosmetic substances, and medications. Patients with acne exhibit an overreaction of the immune system and an excessively intense inflammatory response. The aim of the study is to evaluate selected biochemical and blood count parameters in young women with acne vulgaris. Material and methods: The study was conducted on 20 students of the Academy of Physical Education, aged 20 – 26, including 10 women with mild acne vulgaris and 10 women without acne symptoms. All women underwent complete blood counts (CBC) with the division of leukocytes into subpopulations (5 DIFF) and biochemical tests in blood serum (lipid profile, liver function tests, concentration of total protein and its electrophoretic fractions, CRP). Results: There were no statistically significant differences in the group of women with acne compared to the control group in terms of the assessed serum biochemical parameters. Women with mild acne vulgaris had a significantly lower number of erythrocytes, higher MCV, and a lower percentage of monocytes, with no significant differences in other blood count parameters. The percentage of neutrophils tended to be higher in the group of women with acne vulgaris. Conclusions: 1. Inflammation accompanying mild acne vulgaris may change the number of monocytes and neutrophils in blood counts. 2. The lower number of red blood cells in women with symptoms of acne vulgaris may be the result of chronic inflammation.

HMGB1-RAGE-moesin axis may be indicted for acne vulgaris.

High-mobility group box 1 (HMGB1)-receptor for advanced glycation end (RAGE)-moesin axis could be implicated in induction of inflammation. However, there is a scarcity in literature discussing the role of this axis in inflammatory skin disorders. The aim of the present study was to evaluate the serum levels of HMGB1 and moesin in patients with inflammatory acne vulgaris. This comparative cross-sectional study included 66 inflammatory acne vulgaris patients classified according to Global Acne Grading System (GAGS) into three groups (22 patients each): mild, moderate, and severe acne vulgaris. In addition, 82 acne-free individuals were included as a control group. Serum HMGB 1 and moesin levels were measured using enzyme-linked immunosorbent assay kits. High-mobility group box 1 and moe sin serum levels in acne patients were significantly higher than the levels in control subjects (p=0.04, 0.0005 respectively). Serum levels of both markers in severe acne patients and in those with post-acne scarring were elevated when compared to the levels in the other groups, and however, this elevation was significant only for moesin levels. There was a significant positive correlation between the serum levels of HMGB1 and moesin in the studied patient's sample (r=0.3079, p=0.011). High-mobility group box 1-receptor for advanced glycation end-moesin axis may be implicated in acne vulgaris pathogenesis, and it may be a promising therapeutic target.

Efficacy and Safety of 25% Trichloroacetic Acid Peel Versus 30% Salicylic Acid Peel in Mild-to-Moderate Acne Vulgaris: A Comparative Study.

Both salicylic acid (SA) and trichloroacetic acid (TCA) have proven efficacy with good safety profiles in the treatment of acne vulgaris. This study compared the clinical efficacy and safety of 25% TCA and 30% SA peels in the treatment of mild and moderate acne vulgaris. Patients with mild or moderate acne vulgaris were randomized into 2 groups of 25 persons each, and treated with either the TCA peel or the SA peel at 2-week intervals for 12 weeks. Evaluation of active acne was done by individual lesion counts (comedones, papules and pustules) and calculation of the Michaelsson acne score (MAS). Both peels led to significant decrease in individual lesion counts and MAS compared to baseline values, without significant differences between the treatment groups. Thus, the peels had equivalent efficacy against acne vulgaris. The TCA peel was better in treating non-inflammatory lesions, while the SA peel was better for inflammatory lesions, but the differences were not significant. No serious adverse effects were recorded, but more patients in the TCA peel group experienced burning and stinging sensations. The efficacy of 25% TCA is comparable to that of 30% SA in mild-to-moderate acne vulgaris, but safety and tolerability were better with the SA peel than TCA peel.

CORRELATION OF INTERLEUKIN-23 SERUM LEVELS IN MEN WITH ACNE VULGARIS: A PRELIMINARY STUDY

Background: Acne vulgaris (AV) is an inflammatory condition of pilosebaceous unit that is common in adolescents and young adults. The pathogenesis of AV is multifactorial, one of which is inflammation. Interleukin-23 (IL-23) has an important role in the activity of T helper 17 (Th17) cells that produce IL-17 in chronic inflammation.Objective: To determine the correlation between serum IL-23 levels and AV severity in men.Methods: This is an analytical observational preliminary study with a cross-sectional design involving 15 male subjects with AV who were divided into groups of AV severity based on Lehmann’s criteria. The subjects were examined for serum IL-23 levels. Data were analyzed using Spearman’s Rho non-parametric correlation test to determine the correlation between variables.Results: Mean IL-23 serum levels in men with AV was 111,05 ± 115,27 pg/ml, with mild AV was 210,57 ± 122,038 pg/ml, moderate AV was 103,65 ± 91,15 pg/ml and severe AV was 18,94 ± 15,76 pg/ml. There is a significant correlation between IL-23 serum levels and AV severity in men. (p = 0,001). Serum IL-23 levels decreased with increasing AV severity (r = -0,756).Conclusion: There is a strong negative correlation between IL-23 serum levels and AV severity in men.

Assessment of serum interleukin-19 in acne vulgaris patients of different clinical severities.

Acne vulgaris (AV) is a common chronic inflammatory disorder of the pilosebaceous unit among adolescents and young adults. Inflammation does have a central role in formation of both inflammatory and noninflammatory acne lesions with production of proinflammatory cytokines. To measure serum levels of interleukin 19 (IL-19) in acne vulgaris patients with different severities, and compare it with healthy controls, to evaluate its role in pathogenesis of acne vulgaris and correlate it with acne severity. This study included 120 subjects, aged 18-30years, divided into four groups, 30 in each; mild, moderate, and severe AV patients groups according to acne severity as well as apparently healthy controls group of matched age and sex with no previous history of acne or active acne. Each patient was subjected to history taking, general and dermatological examination with assessment of acne severity. Serum IL-19 levels of both patients and controls were also measured using quantitative enzyme-linked immunosorbent assay (ELISA). Results revealed significant difference in serum IL-19 levels between acne patients and controls, being higher in the former group (P value is<0.001). Moreover, the rise in serum IL-19 levels was significantly proportional to the increased acne severity (P value<0.001). IL-19 is related to the etiopathological inflammatory process of acne vulgaris and correlates with acne severity. It could be proposed as a prognostic inflammatory marker for acne vulgaris.

Pengaruh &lt;i&gt;Astaxantine&lt;/i&gt; Oral terhadap Kadar Serum &lt;i&gt;Tumor Necrosis Factor Alpha&lt;/i&gt; pada Pasien Akne Vulgaris-lores

Background: Acne vulgaris (AV) is chronic inflammatory disease affecting the pilosebaceous unit manifested as closed and open comedones, papules, pustules, and nodules. Treatment of AV generally involves more than one drug due to multifactorial pathogenesis. Objective: This study aims to determine the efficacy of 4 mg oral astaxanthin as an adjuvant AV therapy in decreasing serum level of inflammatory marker tumor necrosis factor alpha (TNF-α). Method: This is a double-blind randomized controlled trial. Subjects were 34 patients with mild and moderate AV (Global Acne Grading System/GAGS 1-30) that were treated with combination of tretinoin 0.025% and clindamycin phosphate 1.2%. Astaxanthin was added to the treatment group and lactulose as placebo was added to the control groups, given for 4 weeks. The pretest and posttest results in both groups were analyzed statistically using nonparametric test. Results: Decrease in TNF-α serum levels occurred in both groups but significant difference compared to baseline were only found in treatment group (p=0.015). There was no significant difference in the reduction of TNF-α levels between both groups (p=0.459). Conclusion: Although the results did not show a significant difference overall, but in the treatment group, astaxanthin can significantly lower TNF-α serum levels compared to baseline.

Efficacy and safety of a new topical gel formulation containing retinol encapsulated in glycospheres and hydroxypinacolone retinoate, an antimicrobial peptide, salicylic acid, glycolic acid and niacinamide for the treatment of mild acne: preliminary results of a 2-month prospective study.

Acne vulgaris is a common and chronic skin disease that impacts on physical and psychological perceptions. Combination therapy with topical retinoids and antimicrobial agent is considered the preferred approach for most of the subjects affected by mild-to-moderate acne. A correct therapeutic management should include a prolonged treatment to ensure therapeutic success and to prevent recurrences. The aim of this study was to evaluate the efficacy and tolerability of a new topical gel formulation that combines retinol encapsulated in glycospheres and hydroxypinacolone retinoate, associated with an anti-microbial peptide (BIOPEP-15) salicylic acid, glycolic acid, and niacinamide as monotherapy in mild acne vulgaris. A 2-month prospective study was conducted at the Unit of Dermatology of the Federico II University. Twenty-five patients aged from 14 to 30 years with mild acne of the face (GAGS score ≤ 18) were consecutively enrolled. Each patient was asked to apply the gel formulation once daily in the evening for 8 weeks. The number of acne lesions with VISIA camera system, the global acne grading system (GAGS) score, trans epidermal water loss (TEWL), skin colorimetry (X-rite Spectrocolorimeter), reflectance confocal microscopy exam were evaluated at baseline, after 4 and 8 weeks of treatment for each patient. Tolerability and safety of the product were also evaluated. Twenty-five female patients with a median age of 23.4 were enrolled. Twenty-two (88%) completed the 2-month treatment period visits. At baseline the total acne lesion number, mean (SD), was 5.5 (4) and the GAG score 9 (4). A significant (P=0.001) reduction in number of total acne lesions was observed at week 4 (-57%) and at week 8 (-80%). All patients presented a significant reduction of the GAGS score values: -42% at week 4 and -78% at week 8, confirming the clinical efficacy of the product. At baseline TEWL was 10.2 g/m2/h (1.3) and 10.7 (1.4) at week 8, thus showing that the gel did not impair the skin barrier function. Skin colorimetry was significantly (P=0.0015) reduced by the treatment in comparison with baseline (62 vs. 58). Efficacy of the gel formulation was also confirmed with RCM exams, showing a reduction of dermal inflammation and exocytosis, and an improvement of infundibular hyperkeratinization. We observed that adherence to treatment correlated positively with the improvement of the single parameters. Moreover, side effects such as erythema, dryness, and excessive xerosis were not reported, resulting in a complete adherence to the treatment. Our findings provide favorable evidences of the efficacy and safety of this new product as a first line treatment in patients with mild acne, or, as a maintenance therapy for prolonged periods after the suspension of a systemic treatment. Furthermore, the tolerability of this topical product and the absence of any side effects increased the adherence to the therapy.

Aspects of comprehensive treatment for adolescents with acne vulgaris from&#x0D; the perspective of psychological counseling

This article discusses the manifestations of the adolescence crisis in patients with acne vulgaris, using a four-level personality model (biological, psychological, social, and spiritual levels). On the one hand, the adolescence crisis can trigger acne vulgaris in case of a genetic predisposition; on the other hand, acne can aggravate the process of experiencing the adolescence crisis. The authors suggest the use of psychological counseling (relaxation techniques, methods of rational psychotherapy, etc.) within the dermatological care for adolescent patients with mild and moderate acne vulgaris. The authors present the results of a study of the efficacy of comprehensive therapy (including psychological counseling) in adolescent patients with mild-to-moderate acne vulgaris, compared with traditional dermatotropic therapy. Statistically significant differences between two groups were revealed in the changes in the indicators of the mental condition presentation (r = -0.90; p 0.05), the dermatological index of acne (DIA) (r = -0.34; p 0.05), and indicators of quality of life (r = -0.72 and r = -0.68. according to the questionnaires of the Dermatology Life Quality Index and Skindex-29, resp.; p 0.05). Simultaneous improvement in the psychoemotional status was correlated with positive cutaneous changes, as evidenced by the direct rather than pronounced statistically significant relationship between the indices of the experience scale and the ADI index (r = 0.52; p 0.05). The obtained results show that the use of psychological counseling in the comprehensive treatment for adolescents with mild-to-moderate acne vulgaris is more effective compared with the traditional dermatotropic therapy.

8-hydroxy-2-deoxyguanosine as a new biomarker of oxidative stress in patients with acne vulgaris

Objectives To evaluate the serum level of 8-hydroxy-2-deoxyguanosine (8-OHdG) in patients with acne vulgaris and also to detect relation between serum level of 8-OHdG and acne vulgaris severity. Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles, characterized mainly by comedones. The precise mechanisms of acne are not known. Oxidative stress within the pilosebaceous unit are considered an important initiating step in the pathogenesis of acne. 8-OHdG is considered to be one of the main biomarkers of oxidative stress. Patients and methods This cross-sectional study was carried out on 75 patients with mild, moderate, and severe acne vulgaris, along with 15 age-matched and sex-matched healthy individuals. Acne severity was assessed by using the global acne score. Blood samples were taken for measuring serum 8-OHdG levels in patients and controls by using commercial enzyme-linked immunosorbent assay kit. Results The serum levels of 8-OHdG were significantly higher in patients with acne vulgaris when compared with healthy individuals (P = 0.005). A strong positive correlation between serum levels of 8-OHdG and acne severity was found (P Conclusion Oxidative stress has an important role in acne pathogenesis represented by elevated 8-OHdG levels.

The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris

Introduction: Generally Acne vulgaris (AV) is considered as a multifactorial disease, and many arguments have been raised on the role of heredity in the etiology of acne, the relevant genetic elements in the pathogenesis of the disease are not well established. Objective: aim of our study was to explore the association between a genetic polymorphism in the promoter region of the CYP17 gene and sebum level on mild and severe the development of acne patients. Methods: There were total 43 samples, consisted of 22 severe AV and 21 mild AV patients. sebum level were measured using Sebumeter. Blood samples were taken from all patients as much as 1 µL. Polymerase Chain Reaction-Sequencing (PCR- sequencing) was used to detect existence of CYP17 gene polymorphism, genome group was observed and the results of the genotype and allele frequencies were compared with sebum level. genotype distribution group was compared with previous researches. Results: Proportion of T gene CYP17 allele frequency is higher than alel C, indicated that T gene CYP17 allele may serve as a risk factor for severe AV cases in Makassar. genotype frequency towards increase of sebum level revealed that TC is two times larger than TT genotype and five times larger than CC genotype. Conclusion: study shows that polymorphisms of CYP 17 gene and the interaction polimorphisms of CYP 17 gene was considered as a risk factor for higher sebum level. How to Cite this Article Pubmed Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP. 2020; 11(5): 288-292. doi:10.31838/srp.2020.5.42 Web Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. http://www.sysrevpharm.org/?mno=108718 [Access: March 29, 2021]. doi:10.31838/srp.2020.5.42 AMA (American Medical Association) Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP. 2020; 11(5): 288-292. doi:10.31838/srp.2020.5.42 Vancouver/ICMJE Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP. (2020), [cited March 29, 2021]; 11(5): 288-292. doi:10.31838/srp.2020.5.42 Harvard Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih (2020) Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. SRP, 11 (5), 288-292. doi:10.31838/srp.2020.5.42 Turabian Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. 2020. Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Reviews in Pharmacy, 11 (5), 288-292. doi:10.31838/srp.2020.5.42 Chicago Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. Systematic Reviews in Pharmacy 11 (2020), 288-292. doi:10.31838/srp.2020.5.42 MLA (The Modern Language Association) Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih. The Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Vulgaris. Systematic Reviews in Pharmacy 11.5 (2020), 288-292. Print. doi:10.31838/srp.2020.5.42 APA (American Psychological Association) Style Evi Mustikawati Arifin, Syafruddin Amin, Anis Irawan Anwar, Budu, Burhanuddin Bahar, Muh. Nasrum Massi, Huldani, Sri Ramadhany, Marhamah F. Singgih (2020) Association between a Genetic Polymorphism in the Promoter Region of the CYP17 Gene and Sebum Level on Acne Reviews in Pharmacy, 11 (5), 288-292. doi:10.31838/srp.2020.5.42

High levels of Helicobacter pylori antigens and antibodies in patients with severe acne vulgaris.

Helicobacter pylori (Hpylori) may play a role in the pathogenesis of extra-intestinal disorders including dermatological diseases. This study aimed to assess the levels of Hpylori antigen and antibody in patients with acne vulgaris (AV). This cross-sectional study compared the levels of fecal Hpylori antigen and serum Hpylori antibody in 100 patients with AV and 100 age and sex-matched healthy volunteers. Patients with AV were classified into mild, moderate, and severe according to the Global Acne Grading Scale. Levels offecal Hpylori antigen and serum Hpylori antibodies were assessed using commercially available enzyme-linked immune-sorbent assay. The patients with severe AV had significantly higher levels of fecal Hpylori antigen as compared to the patients with mild AV, moderate AV, and healthy controls (P<.001). The patients with severe AV had significantly higher serum Hpylori antibody as compared to the patients with mild AV, moderate AV, and healthy controls (P=.001). The levels of fecal Hpylori antigen and serum Hpylori antibody in the patients with mild AV were not significantly different from those in the patients with moderate AV (P=.49 and P=.05, respectively). The patients with severe AV had higher levels of fecal Hpylori antigen and serum Hpylori antibody as compared to the patients with mild and moderate AV and with healthy controls. The indicators of Hpylori infection were positively correlated with the severity and duration of AV.

Efficacy of Adapalene 0.1% Versus Tretinoin 0.025% Cream as Treatment of Mild Acne Vulgaris

Abstract&#x0D; &#x0D; Introduction: Acne vulgaris (AV) is a chronic inflammatory of the pilosebaceous unit. Topical retinoid is a mainstay of mild AV first-line treatment.&#x0D; Aim of study: To assess the efficacy of topical retinoid for the treatment of mild AV.&#x0D; Method: The randomized double-blind clinical trial was conducted from June to September 2019 at Dr. Mohammad Hoesin General Hospital Palembang. A total of 70 mild AV patients who fulfilled inclusion criteria were enroled consecutively. Patients randomly treated with adapalene 0.1% cream or tretinoin 0.025% cream and evaluated every 2 weeks for 8 weeks to examine the number of AV lesion (inflammation, non-inflammation and total lesion).&#x0D; Result: There are reduction in number of inflammatory and non-inflammatory lesions at both groups but only inflammatory lesion was statistically significant (p &lt;0.05). Total lesions also decrease in adapalene and retinoin group (21.66 vs 5.75, 22.21 vs 7.96, respectively) and statistically significant (p &lt;0.05).&#x0D; Conclusion: Adapalen 0.1% cream showed non-inferiority to tretinoin 0.025% cream in efficacy, especially in the reduction of non-inflammatory and total lesions.

A study of effectiveness and safety of topical combination therapy for acne vulgaris patients in dermatology department of a tertiary care teaching hospital

Background: Acne vulgaris is a dermatological disorder characterised by formation of comedones and inflammatory lesions. Acne is one of the most common reason for visiting a dermatologist in early adulthood. The current line of management for mild to moderate acne is topical medications with antimicrobials and retinoids. The present study assessed the effectiveness and safety of topical combination therapy for mild to moderate acne vulgaris.Methods: An observational, prospective and comparative study conducted on newly diagnosed acne vulgaris patients who were treated with topical combination therapy. Changes in the total, inflammatory and non-inflammatory lesion counts, investigator global assessment (IGA) and dermatology life quality index (DLQI) scales were recorded to check effectiveness. Treatment emergent adverse events were recorded in suspected ADR reporting form for safety assessment.Results: Participants (n=97) were treated with three topical combination treatments either clindamycin-benzoyl peroxide (group-A), clindamycin-adapalene (group-B) or benzoyl peroxide-adapalene (group C). Majority of participants (42.3%) were treated with clindamycin-benzoyl peroxide group. Reduction from baseline of total, inflammatory and non-inflammatory lesion counts were highly significant within group comparison (p&lt;0.001), but between group differences were not significant. Significant improvement in DLQI and IGA scores were noted in all three groups, but between group comparison showed no significant differences. All three groups were safe and well tolerated and equally improve participant’s quality of life.Conclusions: all three topical combination drugs for mild acne vulgaris had similar effectiveness in terms of reduction in acne lesions with similar safety profile.

ASSESSMENT OF THE RISK OF SKIN LESIONS ASSOCIATED WITH DEMODEX MITES IN STUDENTS WITH ACNE VULGARIS

The study of comorbid pathologies that influence the severity of the disease and impair the effectiveness of treatment is carried out to optimize the treatment of the main disease. Materials and methods. The total of 132 medical students was divided into two groups: the 1st group: 56 students who didn`t have acne elements, the 2nd group: 76 students with mild acne vulgaris. At the baseline and after 12 months epithelial tape-test was performed to define Demodex mites presence. The theory of chances was used to assess the impact of acne on the occurrence of Demodex mites. Results. The presence of Demodex mites was observed in 3.57% of students in the 1st group and in 21.05% of students in the 2nd group on repeated tape-test. The probability value (P) among students of the 1st group was P1 = 0.037; among students of the 2nd group – P2 = 0.266. The odds (O) indicator in the 1st group of students without acne elements was O1 = 0.04, in the 2nd group diagnosed with acne – O2 = 0.21. The odds ratio (OR) value in the case/control groups was 7.20. Confidence intervals (95% CI) – (1.582, 32.765): the lower limit of the confidence interval (2.019, + ∞); the upper limit of the confidence interval (-∞, 25680). The significance test p-value was 0.00533. Conclusion. Acne vulgaris is one of the aggravating factor that increases the risk of Demodex mites.