Mild Acne Vulgaris Research Articles

The effect of topical retinoids in treatment of acne vulgaris in Khartoum Teaching Dermatological Hospital

Background: Acne vulgaris is a chronic inflammatory skin disease affecting approximately 80% of young adults and adolescents. Prolonged therapy is often required for satisfactory results. Topical retinoids play a central role in acne treatment, with evidence supporting their efficacy in achieving significant improvements in acne symptoms. This study aimed to assess the effectiveness of topical retinoids in treating acne vulgaris among patients at Khartoum Dermatology and Venereal Teaching Hospital from August 2019 to August 2020. Methods: A non-randomized interventional study was conducted at Khartoum Dermatology Teaching Hospital, covering patients diagnosed with mild to moderate acne vulgaris. Data were entered, cleaned, and analysed using statistical package for the social sciences (SPSS) version 25.0. Results: The study included 100 patients. Of these, 38% were aged 25-35 years, and 70% were female. 92% had experienced acne symptoms for more than six months. Regarding treatment duration, 87% used topical retinoids for more than three months. Clinical improvement was observed in 83% of patients, while 14% showed no improvement, and 3% experienced worsened symptoms. Conclusions: Topical retinoids are effective in treating mild and moderate acne vulgaris.

Efficacy and Tolerability of Topical Dapsone vs Benzoyl Peroxide in Mild to Moderate Acne Vulgaris Treatment: A Retrospective Study

Aim: Acne vulgaris is a disease of the pilosebaceous unit and a chronic inflammatory process. This study aimed to compare topical 5% dapsone and 10% benzoyl peroxide in terms of efficacy, side effects, and patient satisfaction in mild to moderate acne. Material and Methods: The patients who applied to the dermatology outpatient clinic with the complaint of acne between June 20, 2022, and September 20, 2022, and were diagnosed with mild and moderate acne vulgaris, were retrospectively evaluated. Forty-eight patients in the dapsone group and 53 in the benzoyl peroxide group were included in this study. Results: At the end of the treatment, a statistically significant difference was found between the two groups in terms of ISGA values and improvement percentage in ISGA, improvement was higher in the dapsone group (both p=0.001). A statistically significant difference was found between the groups in terms of the percentage decrease in lesion counts of closed comedones, papules and pustules, inflammatory and total lesions (decreasement was higher in the dapsone group, p=0.038 for closed comedones, p=0.006 for total lesions and p<0.001 for others). There was no dissatisfied patient in the group using dapsone (p<0.001). Among the side effects, erythema was more common during the whole treatment, and dryness and burning-stinging sensation were higher at the end of the first month in the benzoyl peroxide group. Conclusion: Topical 5% dapsone is effective in the treatment of mild to moderate acne and is safe in terms of side effects compared to topical 10% benzoyl peroxide.

Helicobacter pylori and acne vulgaris: is there a relationship?

Background: Helicobacter pylori (H. pylori) is a gastric Gram-negative, spiral-shaped microaerophilic pathogen. H. pylori may play a potential pathogenic role in extra-intestinal diseases such as hepatobiliary, respiratory, and dermatological disorders. The latter included chronic urticaria, psoriasis and rosacea. The first report in literature on the relationship between H. pylori and acne vulgaris (AV), found association between severe AV and H. pylori infection. There are very limited data in AV patients addressing the impact of H. pylori infection on various severities. In this context, the aim of the present work was to determine the association of H. Pylori infection among AV patients and correlate it with the disease severity. Methods: This case-control study included 45 Patients with AV and 45 age and sex matched healthy volunteers as a control group. H. pylori antigen in stool and serum H. pylori antibody IgG using commercially available ELISA kits was tested in all included subjects. Results: The percentage of participants with a positive H. pylori antigen in stool and positive H. pylori antibody in serum in the whole study population was 35/90 (38. 9%) and 41/90 (45. 6%). On comparing between the percentages of positive H. pylori antigen in stool and positive H. pylori antibody in serum between the patients with AV and healthy controls, a highly statistically significant difference was found between the two groups (P < 0.001, P = 0.006). On comparing between the percentages of positive H. pylori antigen in stool and positive H. pylori antibody in serum in the patients with different grades of acne severity and healthy controls, the rate of positive H. pylori antigen in stool and positive H. pylori Ab in serum was significantly associated with severity of acne comparing with healthy controls (p < 0. 001). Conclusion: The rate of H. pylori infection in patients with AV is high so it may influence the pathogenesis of this skin disease. Patients with severe AV had higher rates of H. pylori antigen in stool and H. pylori antibody in serum as compared to the patients with mild AV and healthy controls.

Polyherbal Antiacne Gel: In Vitro Antibacterial Activity and Efficacy Evaluation Against Cutibacterium acnes.

Acne is a common skin condition that affects people of all ages and can lead to significant physical and psychological distress. The first line of action against acne is topical products, though the most effective are topical antibiotics. In such a scenario, the development of effective and safe herbal formulations for the treatment of acne is of great importance. Rubia cordifolia, Aloe barbadensis, and Allium cepa extracts are rich sources of bioactive metabolites and are safe compared with antibiotics, in addition to being cost effective, sustainable, and eco-friendly. Also, their combination has not been studied for treating acne, and their potential benefits need to be investigated. The present study aimed to develop an effective polyherbal gel formulation of R. cordifolia, A. barbadensis, and A. cepa combined extract for treating acne and validate its effect with reference to conventional antibiotics. Plant materials were extracted in water by the reflux method, and phytochemical analysis was done for flavonoid, anthraquinone, and phenolic contents. The combined extract (R. cordifolia, A. barbadensis, and A. cepa extracts) was formulated in gel. The selected polyherbal gel was evaluated for in vitro antibacterial activity using agar well diffusion against Cutibacterium acnes (P. acnes) culture. Phytochemical analysis of the composite extract revealed the rich presence of flavonoids, phenolics, and anthraquinones. The polyherbal gels showed good physicochemical properties; however, FCEG-4 was selected for further studies. It was found to be effective against C. acnes (MTCC 1951) in agar well diffusion, as it showed a similar zone of inhibition as that of standard. Also, during invivo studies, FCEG-4 showed comparable efficacy with clindamycin gel. It was concluded from the study that composite extracts incorporated in an aqueous-based gel system were effective in topical therapy of mild acne vulgaris, showing similar efficacy to that of clindamycin cream.

Comparative study on efficacy of benzoyl peroxide with adapalene versus plain adapalene in the treatment of acne vulgaris

BACKGROUND Acne vulgaris is a dermatological disorder of pilosebaceous unit, characterized by formation of comedones and inflammatory lesions. It is one of the most common skin manifestations among adolescents, also affecting the adult population. The treatment of acne basically involves reduction of lesions and prevention of permanent scarring. The current line of treatment for mild to moderate acne is topical medications with antimicrobials and retinoids. The present study assessed the efficacy of combination of adapalene and benzoyl peroxide in comparison to adapalene for topical treatment of mild to moderate acne vulgaris. OBJECTIVE The purpose of the study was to compare the clinical efficacy of topical adapalene and topical adapalene with benzoyl peroxide in treatment of mild to moderate cases of acne vulgaris. METHODOLOGY A prospective, comparative study was carried out among 84 patients with mild and moderate acne vulgaris visiting the Department of Dermatology, Kathmandu Medical College and Teaching Hospital, Bhaktapur, Nepal from December 2019 till March 2021. The patients fulfilling the inclusion criteria were divided into two groups. Group A received topical adapalene whereas Group B received topical adapalene with benzoyl peroxide. The efficacy of treatment in both groups were determined based on the reduction of total lesion count. Both inflammatory and non-inflammatory lesions were counted at 4th week, 8th week and 12th week. RESULTS All patients were assessed according to Global Acne Grading System (GAGS) and grouped as mild and moderate. The most frequent age group affected by acne vulgaris was 18-22 years. The mean age was 22.15 ± 5.315. Females (64.30%) were affected more commonly than males (35.7%). Majority of patients presented with moderate or inflammatory acne lesions. The face (90.5%) was most commonly affected site by acne vulgaris. The number of patients enrolled in the study were 84 out of which 63 (75%) completed the study. It was found that the reduction of non-inflammatory, inflammatory and total lesion count from the baseline were highly significant in between and both the group (P&lt;0.001). A total of 52.4% had very good result of the treatment, 44.4% of them had good result and remaining 3.2% of the patients’ result was fair. However, the efficacy of benzoyl peroxide with adapalene was found to be better than adapalene alone. CONCLUSIONThis study concluded that topical benzoyl peroxide with adapalene is more efficacious to treat mild to moderate acne vulgaris.

Factors that Influence The Onset of Acne Vulgaris :Retrospective Study

Background: Acne vulgaris (AV) is a skin condition that mostly occurs in adolescents, although it can occur at any age. Most occur during adolescence, with a prevalence of around 85%. Acne vulgaris is a multifactorial disease triggered by many factors, namely, genetics, environment, hormonal and emotional stress, food, trauma, cosmetics, and medications. Purpose: This study identifies the precipitating factors of acne vulgaris. Methods: This study was retrospective based on medical record data at the Dermatology and Venereology Outpatient Clinic of Dr. Soetomo General Academic Hospital Surabaya in the period January 2018–December 2019. Results: The number of AV patients within 2 years from January 2018 to December 2019 obtained 517 cases of acne vulgaris patients with complete data. There were female AV patients (80.7%) and male AV patients (19.3%). The most common age of AV patients was 15–24 years old (60.5%), the most common occupation of AV patients was student (59.8%), and patients suffered from AV for &gt;12 months (18.6%). The most precipitating factors for AV are hormonal (69.6%) and cosmetic (50.1%); the most common type of AV is mild AV (64.2%); and the most common AV therapy is the combination of topical tretinoin, benzoyl peroxide (BPO), and topical clindamycin. Conclusion: The results of this study showed that hormonal and cosmetic precipitating factors caused most AV patients in women.

Bioactive Compounds from Medicinal Plants as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

In recent years, there has been a growing interest in the use of medicinal plants and phytochemicals as potential treatments for acne vulgaris. This condition, characterized by chronic inflammation, predominantly affects adolescents and young adults. Conventional treatment typically targets the key factors contributing to its development: the proliferation of Cutibacterium acnes and the associated inflammation. However, these treatments often involve the use of potent drugs. As a result, the exploration of herbal medicine as a complementary approach has emerged as a promising strategy. By harnessing the therapeutic properties of medicinal plants and phytochemicals, it may be possible to address acne vulgaris while minimizing the reliance on strong drugs. This approach not only offers potential benefits for individuals seeking alternative treatments but also underscores the importance of natural remedies of plant origin in dermatological care. The primary aim of this study was to assess the antimicrobial, antioxidant, and anti-inflammatory properties of plants and their phytochemical constituents in the management of mild acne vulgaris. A comprehensive search of scientific databases was conducted from 2018 to September 2023. The findings of this review suggest that medicinal plants and their phytochemical components hold promise as treatments for mild acne vulgaris. However, it is crucial to note that further research employing high-quality evidence and standardized methodologies is essential to substantiate their efficacy and safety profiles.

Profile of Mild Acne Vulgaris Patients at Tertiary Hospital at Surabaya, Indonesia

Background: One of the most prevalent skin conditions worldwide is acne vulgaris (AV). Even mild forms of AV could have an adverse impact on psychological wellbeing. Purpose: To explore the profile of mild AV patients in a tertiary care facility in Surabaya, Indonesia. Method: This was a descriptive study conducted for eight weeks. Data regarding the patient's identity, history, skin type, and complaints related to AV or other complaints that arose were noted on the sample’s medical record and collected for analysis. The Lehmann classification was used to assess the AV degree. Result: A total of 34 patients were included. Gender equality was similar in our study, and late adolescence (17-25 years) is the most dominant age group (73.5%). Genetics plays the biggest precipitating factor (73.5%), followed by stress (70.6%). Most patients had an oily skin type (91.2%) with Fitzpatrick’s phototype 4 (85.3%). Comedone is the most prevalent lesion in our study (median = 10, range = 4-20). Conclusion: Most patients with mild AV had an oily skin type, and late adolescent is most dominant age group.

The Effectiveness Of Salicylic acid Therapy In Mild and Moderate Acne Vulgaris

Background: Acne vulgaris is a chronic inflammatory disease of polysebaceous follicles characterized by lesions that include blackheads, papules, pustules, nodules, and cysts. The prevalence of acne vulgaris is most significant among adolescents aged 15 to 18. In mild and moderate acne vulgaris, topical treatment enhances skin conditions. It is believed that the ability of salicylic acid to reach the stratum corneum, which exfoliates due to its comedolytic properties, aids in the healing of acne vulgaris.Objective: Evaluate the efficacy of salicylic acid as a treatment for mild and moderate acne vulgaris.Methods: This study's design involved a literature search using the terms acne vulgaris and salicylic acid in Google Scholar, PubMed, and Science Direct.Results: The investigation found 108 articles were discovered and excluded based on the restriction criteria; 8 articles were reviewed. Salicylic acid substantially improved mild and moderate acne, according to all studies. Improvement was measured based on the lesion's severity, the lesion type, and Goodman's qualitative global scarring grading system. There is an improvement in inflammatory, non-inflammatory, and hyperpigmented lesions.Conclusion: Salicylic acid is clinically beneficial for mild to moderate acne vulgaris.

The Relationship Between the Severity of Acne Vulgaris and the Quality of Life of Prima Indonesia University Medical Faculty Students

Acne vulgaris, or acne, is a chronic inflammatory disease of the pilosebaceous follicles, characterized by the appearance of open and closed comedones, papules, pustules, nodules, seborrhea, and cysts. Acne vulgaris can occur in teenagers and young adults, such as medical school students, affecting their quality of life. This research aimed to determine the relationship between the severity of acne vulgaris and the quality of life of students. This type of research is analytical observational research with a cross-sectional design. The population in this study were students from the Faculty of Medicine, Prima Indonesia University, class 2020 – 2021, who suffered from acne vulgaris. The research sample obtained was 38 people. Sampling was purposive sampling. Data was obtained from a questionnaire filled out via the Google Form link. Data were analyzed univariately and bivariately using the Spearman Rho Rank test at a % confidence level of 95% (a=0.05). The results showed that the severity of acne vulgaris of students at the Faculty of Medicine, Prima Indonesia University (71.1%) was mild. The quality of life of students was in the mild disorder category (52.6%). The severity of acne vulgaris in students is significantly related to the quality of life of students at the Faculty of Medicine, Prima Indonesia University (p = 0.001 &lt; 0.05), with the close relationship (correlation coefficient) of the two variables in the medium category (r = 0.522). The majority of respondents indicated the presence of mild acne vulgaris, reflecting the potential for awareness of good skin health practices.

Body Dysmorphia and Selfie Behavior of Filipino Patients With and Without Mild Acne Vulgaris: A Descriptive Cross-Sectional Study

Background: Acne vulgaris (AV) is a chronic inflammatory skin condition that is non-life-threatening but may cause significant psychological morbidity regardless of severity. An extreme case of this is depicted in body dysmorphic disorder (BDD), which is often an undiagnosed condition presenting with excessive preoccupation of perceived flaws not observable by others. With the increasing popularity of social media throughout the years, there has been budding researches exploring its psychological implications, particularly on “selfies” and its possible association with self-image and body dysmorphia. Objectives: To compare body dysmorphic symptoms and selfie behavior between patients with mild AV versus those without AV. Methods This is a single-center, cross-sectional study among patients with mild AV and those without AV seen through a teledermatology platform of a tertiary hospital from April to June 2022. Results: A total of 207 patients were included in this study – 107 patients with mild AV and 100 patients without AV. A significantly higher proportion of BDD symptoms was seen in patients with mild AV using either Body Dysmorphic Disorder Questionnaire-Dermatology Version (BDDQ-DV) (31%) and Dysmorphic Concern Questionnaire (DCQ) (14%). No significant difference was noted in terms of selfie behavior between the groups. Conclusions: BDD symptoms were significantly more prevalent in patients who have mild AV despite having lesions that are negligible and clinically not apparent. This highlights the importance of dermatologists’ knowledge that BDD may cause distress and impairment and should be taken into consideration in terms of management. Interestingly, selfie behavior of patients with mild AV and without AV had no significant difference. Key words: Body dysmorphia, acne vulgaris, social media, selfie behavior, cross-sectional

Efficacy of Two Moroccan Cistus Species Extracts against Acne Vulgaris: Phytochemical Profile, Antioxidant, Anti-Inflammatory and Antimicrobial Activities.

The genus Cistus L. (Cistaceae) includes several medicinal plants growing wild in the Moroccan area. Acne vulgaris (AV) is a chronic skin disorder treated with topical and systemic therapies that often lead to several side effects in addition to the development of antimicrobial resistance. Our study aimed to investigate the bioactivity of extracts of two Moroccan Cistus species, Cistus laurifolius L. and Cistus salviifolius L., in view of their use as potential coadjuvants in the treatment of mild acne vulgaris. Targeted phytochemical profiles obtained by HPLC-DAD and HPLC-ESI/MS analyses and biological activities ascertained by several antioxidants in vitro chemical and cell-based assays of the leaf extracts. Moreover, antimicrobial activity against Gram-positive and Gram-negative bacteria, and Candida albicans was evaluated. Analyses revealed the presence of several polyphenols in the studied extracts, mainly flavonoids and tannins. Cistus laurifolius L. and Cistus salviifolius L. possessed good biological properties and all extracts showed antibacterial activity, particularly against Staphylococcus aureus, S. epidermidis, and Propionibacterium acnes, identified as the main acne-causing bacteria. The results suggest that examined extracts are promising agents worthy of further studies to develop coadjuvants/natural remedies for mild acne treatment.

Distinct skin microbiome modulation following different topical acne treatments in mild acne vulgaris patients: A randomized, investigator-blinded exploratory study.

The effects of topical non-antibiotic acne treatment on skin microbiota have rarely been demonstrated. In the study, we randomized 45 mild acne vulgaris participants into three treatment groups, including a cream-gel dermocosmetic containing Aqua Posae Filiformis, lipohydroxy acid, salicylic acid, linoleic acid, niacinamide and piroctone olamine (DC), retinoic acid 0.025% cream (VAA) and benzoyl peroxide 2.5% gel (BP). At months 0, 1 and 3, skin specimens were swabbed from the cheek and forehead and sequenced by targeting V3-V4 regions of the 16 S rRNA gene. QIIME2 was used to characterize bacterial communities. Acne severity, sebum level and tolerability were assessed concomitantly in each visit. We found that both VAA and BP could significantly reduce the bacterial diversity at month 1 (p-value=0.010 and 0.004 respectively), while no significant reduction was observed in DC group. The microbiota compositions also significantly altered for beta diversity in all treatments (all p-value=0.001). An increased Cutibacterium with decreased Staphylococcus relative abundance was observed at months 1 and 3 in DC group, while an opposite trend was demonstrated in VAA and BP groups. These findings suggest a potential impact of DC, VAA and BP on the diversity and composition profiles of the skin microbiota in mild acne participants.

ORAL RESVERATROL AS AN ADJUVANT THERAPY IN THE TREATMENT OF MILD TO MODERATE ACNE VULGARIS: A PROSPECTIVE OBSERVATIONAL STUDY

Background: Acne vulgaris is an inammatory skin disease usually affecting individuals between 12 and 24 years of age. Many topical and systemic agents are used in the treatment of acne, based on the grade. Complementary and alternative medicine therapies like vitamin C, nicotinamide, zinc, resveratrol, curcumin, etc. are increasing in popularity in the treatment of acne and rosacea. Resveratrol is a natural ingredient that is most abundant in the skin of red grapes, blueberries, boiled peanuts, etc. Resveratrol has considerable anti-inammatory, antioxidant, antiaging, and anti-microbial properties. However, there is a paucity of data regarding the use of oral Resveratrol in the management of acne; hence, this study is undertaken. To study the effectiveness of oral resveratrol as a Aim: n adjuvant therapy in patients with mild to moderate acne vulgaris. Materials And Methods: Forty-six patients diagnosed with mild or moderate acne vulgaris were sampled via consecutive sampling and assigned to two groups, those receiving a combination of topical 1% clindamycin plus 0.1% adapalene and oral resveratrol 50 mg (24) and those receiving topical 1% clindamycin plus 0.1% adapalene (22). Both groups were assessed at weeks 4, 8, and 12 by applying the global acne grading system, and side effects were noted. Both groups showed remarkable responses at weeks 4, 8, a Results And Conclusions: nd 12. However, the Resveratrol group showed an earlier response at weeks 4 and 8, with an early decrease in lesion counts. On intergroup comparison, no signicant difference was found in terms of response rates at week 12. As a result of our ndings, resveratrol appears to be effective as adjuvant therapy in the treatment of acne vulgaris It has the advantage of better tolerability as compared to topical 1% Clindamycin plus 0.1% adapalene

Clinical Profile and Treatment of Acne Vulgaris Patients

Background: Acne vulgaris (AV) is not a deadly condition may affect one’s quality of life. Treatment of AV includes topical and oral, depending on the severity. Antibiotics as oral treatment should not be given alone because it can precipitate resistance. Purpose: To describe the clinical characteristics of AV in a tertiary hospital in Indonesia and evaluate the treatment given. Methods: This is a descriptive, retrospective study with a cross-sectional design. The study subject was classified based on severity according to Plewig and Kligman’s acne grading. Further evaluation was made according to the type of lesion, the risk factortopical and oral treatment in subjects with grades 2, 3, and 4. This research was conducted at the Cosmetic Medic Division, Dermatology and Venereology Outpatient Clinic at Dr. Soetomo General Academic Hospital Surabaya based on medical records from the period of 2017 to 2019. Result: From 2017 to 2019, there were 525 (1.1%) new AV patients out of a total of 45,754 new patients. AV was the major diagnosis in the Cosmetic Medic division. AV grades 2, 3, and 4 were found in 167 patients (32.0%). The most common lesion was papulopustular (75.4%) and the most common risk factor was hormonal (58.7%). All the patients received tretinoin, clindamycin gel 1.2%, and sunscreen for topical treatment. Doxycycline was the most common oral antibiotic used (98.2%) Conclusion: The most common AV grade in this study was mild AV. Oral antibiotics were given to moderate-to-severe AV patients in combination with topical treatment to prevent resistance.

Efficacy of Hydrogen Purification and Cosmetic Acids in the Treatment of Acne Vulgaris: A Preliminary Report.

Acne and skin lesions that appear in its course deteriorate the quality of life of patients, cause depression and the emergence of suicidal thoughts. Cosmetic treatments can have a positive effect on improving skin condition by cleaning up skin eruptions, thus improving the well-being of affected people. Hydrogen purification is a treatment that uses alkaline water generated by a device, which reduces sebum from the surface of the epidermis. This is a novel treatment that has recently been introduced to beauty salons. On the other hand, cosmetic acids have been used for many years for treating people with acne vulgaris and give spectacular results in terms of improving the skin condition. In this study, skin condition was evaluated with a Derma Unit SSC 3 device. The Global Acne Grading System (GAGS) was used to check acne severity. Twenty-four women aged 19-21 years (M = 20.13, SD = 0.80) diagnosed with mild acne vulgaris and a high sebum level participated in the study. Group A underwent a hydrogen purification treatment using an H2jet manipulator, which ejected alkaline water from the manipulator under pressure. Group B underwent a hydrogen purification treatment with the use of a phytic, pyruvic, lactic and ferulic acids at 40% mixture (pH 1.4). A series of four treatments was performed at 14-day intervals in both groups. Skin parameters were measured before and 30 days after the series of treatment. Very good results were obtained in both groups. The skin eruptions in patients were reduced and we also observed lower amounts of sebum on the surface of the epidermis, and an improvement in skin hydration. However, in group B, the results were better than in group A. The study showed that the synergy of the treatments produced much better effects than those obtained by completing the hydrogen purification treatment alone.

HUBUNGAN STRES DENGAN KEJADIAN TIMBULNYA ACNE VULGARIS PADA SISWA DI SMP NEGERI 2 KOTA BANDA ACEH

Stress can not only affect a person’s psyche but can also affect in term of pathophysiology. Stress causes one of the skin disease that are often a problem for adolescents and adults, namely acne vulgaris. This study aims to determine the relationship of stress with the incidence of acne vulgaris. This study used a correlational descriptive by incorporating the cross-sectional design. The total sample was 81 respondents. The measuring instrument used is a questionnaire and GAGS (Global Acne Grading System) observation sheet. Validity test using the item-total correlation, the results of the validity value r &gt; 0,444 and declared valid. The reliability test obtained the results of the cronbach alpha value of 0,60, so it can be concluded that the instrument is declared reliable. Bivariate test showed that there was correlation between stress and the incidence of acne vulgaris among students in SMP Negeri 2 Banda Aceh 2019 with p-value = 0,001. Moderate acne vulgaris mostly occurs in students who experience stress, while mild acne vulgaris occurs in students who do not experience stress.

Increased Vitamin A Level is associated with Clinical Improvement in Mild Acne Vulgaris: A Pre-test and Post-test Clinical Trial

AV is a global cutaneous disorder that although is benign, can significantly affect the patient’s quality of life. The pathognomonic feature of the disease is the emergence of comedones. There are four known pathophysiology of AV, increased sebum production, ductal cornification, colonization of the bacteria P. acnesin the pilosebaceous unit, and inflammation. Furthermore, Vitamin A although already a well-established acne treatment that can affect all four of these factors, here are still limited data regarding the quantitative measurement of vitamin A itself in acne vulgaris cases. This study seeks to review the association between vitamin A levels measured quantitatively using ELISA with the outcome of inflamed lesions and comedones prior and after treatment with Tretinoin 0.025% in patients with mild AV. Our studies found that increased level of vitamin A is associated with significant clinical improvements in both inflamed and non-inflamed AV lesions.

Adapalene-Benzyl Peroxide Combination as an Option for Acne Vulgaris Treatment: A Systematic Literature Review

Background: Acne vulgaris affect 9,4% of the world population, especially in teenage age. Treatment of acne is based on severity; mild acne is treated with a topical agent, whereas moderate and severe acne is treated with topical and systemic agents. Topical therapy, including retinoids, antibiotics, and benzoyl peroxide, is the foundation of acne treatment. Adapalene-benzoyl peroxide therapy can be used in treatment to avoid antibiotic resistance. This study aimed to evaluate the efficacy and tolerance of adapalene/benzoyl peroxide topical treatment in mild to moderate acne vulgaris.&#x0D; Methods: This systematic review conducted a literature search through 3 databases, following PRISMA 2020 guidelines. Inclusion criteria were written in English or Indonesian, published in 2016-2020, a randomized controlled trial (RCT) study designed using human samples, and discussed the efficacy of topical adapalene-benzoyl peroxide in mild and moderate acne vulgaris. Studies that were unavailable in full text and based on secondary data were excluded.&#x0D; Results: Acne vulgaris lesions and scars decreased significantly with adapalene/benzoyl peroxide topical therapy. The addition of moisturizer to therapy can reduce the side effects of retinoate.&#x0D; Conclusion: The combination of adapalene/benzoyl peroxide can be an alternative treatment for mild to moderate acne.

Efficacy of Oxybrasion in the Treatment of Acne Vulgaris: A Preliminary Report.

There are many cosmetic methods to reduce skin eruptions in people with acne vulgaris. As oxybrasion is a safe method of exfoliating dead epidermis, our objective was to investigate its effectiveness in young women with acne vulgaris. The Global Acne Grading System (GAGS) and Derma Unit SSC 3 device (Sebumeter SM 815, Corneometer CM 825) were used to assess acne vulgaris and skin properties. Twenty-four women aged 19–21 years (M = 19.50, SD = 0.66) with diagnosed mild acne vulgaris and a high level of sebum (more than 100 μg/cm2) participated in the study. Women on any dermatological treatment within the last 12 months and/or hormonal contraception were excluded. Probands were randomly assigned to two equal groups. Group A (experimental) was oxybrased with 0.9% sodium chloride solution simultaneously with compressed oxygen. Group B (placebo) was the group treated with non-carbonated mineral water and oxygen from the device (not pure). A series of five treatments was performed at 10-day intervals. Skin parameters were measured before and 30 days after the end of treatment. As a result, in group A (experimental), skin hydration and GAGS improved, while sebum on the epidermis was reduced. No side effects were noted. We concluded that oxybrasion is effective in women with acne and safe, as it improved skin parameters; however, further research is needed.